Temporal Trends in Comorbidity Burden and Impact on Prognosis in Patients With Acute Coronary Syndrome Using the Elixhauser Comorbidity Index Score

Prognostic impact of comorbidity measures on outcomes following acute coronary syndrome: A systematic review

“…A total of 4166 studies were retrieved from our search. After excluding studies that did not meet the inclusion criteria, a total of four retrospective studies [26][27][28][29] and eight prospective studies 18,19,[30][31][32][33][34][35] were included (Figure 1). In addition, we identified another 10 studies 20,21,[36][37][38][39][40][41][42][43] that did not report any prognostic impact of comorbidity measure on ACS outcomes however offered information on model comparison in terms of predictive performance of different comorbidity measures.…”

“…The study designs and cohort characteristics of each included paper are presented in Table 1. Among four retrospective studies, one 26 had a follow up of 24 years, two had an 11-year follow-up, 27,28 one had a follow up of one year. 29 The remaining eight prospective studies had follow-up duration between half a year and ten years.…”

“…The majority of the studies were conducted in European countries including five from Spain, 19,31,32,34,35 one from Italy, 30 one from Denmark 26 and one from Switzerland, 33 with the exception of one from Israel 18 and two from the United States. 27,28 Most studies were published as a full research manuscript although two were published as an abstract. 32,34 There was no age limitation in most studies except three studies [26][27][28] with an age limit of 15 years old or higher and two studies 19,34 which focused on patients aged ≥65 years and aged ≥80 years, respectively.…”

“…27,28 Most studies were published as a full research manuscript although two were published as an abstract. 32,34 There was no age limitation in most studies except three studies [26][27][28] with an age limit of 15 years old or higher and two studies 19,34 which focused on patients aged ≥65 years and aged ≥80 years, respectively.…”

“…Our review included a total of 6 885 982 patients with the sample size of individual studies ranging from 520 to 6 613 623 patients. The study populations comprised patients with ACS (N = 6 645 339 in five study [27][28][29]33,34 ), those with AMI (total N = 237 251 in three studies 18,26,31 ), those with NSTEMI (total N = 2652 in three studies 19,32,35 ), and those with STEMI (N = 740 in one study 30 ). The mean ages ranged from 66 to 74 years old from studies which reported such data.…”