Transplanting candidates with stacked risks negatively affects outcomes

Cantu, E.; Dun, Jin; Mccurry, M.; Friskey, Jacqueline; Saleh, A; Diamond, Joshua M.; Anderson, Michaela R.; Clausen, Emily; Hsu, Jesse Y.; Gallop, Robert; Christie, Jason D.; Schaubel, Douglas E.

doi:10.1016/j.healun.2023.05.020

Cited by 1 publication

(1 citation statement)

References 17 publications

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“…Secondly, reactive oxygen species generated by an influx of cytosolic calcium during warm and cold ischemic times in response to ATP generation creates a cycle of inflammatory changes and eventual endothelial damage, which leads to more inflammation from increased capillary permeability and cytokine release, ultimately leading to cell death in the donor allograft ( 6 , 7 ). Furthermore, the milieu of donor and recipient risk factors, which we will discuss in this article, are also key in the pathophysiology of PGD ( 8 , 9 ). Importantly, PGD is strongly associated with the development of chronic lung allograft dysfunction (CLAD), which is the primary cause of long-term morbidity and mortality after LTx ( 10 , 11 ).…”

Section: Introductionmentioning

confidence: 99%

Donor and recipient risk factors for the development of primary graft dysfunction following lung transplantation

Jenkins,

Verdiner,

Omar

et al. 2024

Front. Immunol.

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Primary Graft Dysfunction (PGD) is a major cause of both short-term and long-term morbidity and mortality following lung transplantation. Various donor, recipient, and technical risk factors have been previously identified as being associated with the development of PGD. Here, we present a comprehensive review of the current literature as it pertains to PGD following lung transplantation, as well as discussing current strategies to mitigate PGD and future directions. We will pay special attention to recent advances in lung transplantation such as ex-vivo lung perfusion, thoracoabdominal normothermic regional perfusion, and up-to-date literature published in the interim since the 2016 ISHLT consensus statement on PGD and the COVID-19 pandemic.

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