Temporal resolution of idiopathic granulomatous mastitis with resumption of bromocriptine therapy for prolactinoma

Bouton, Marcia E.; Winton, Lisa M.; Gandhi, Sonal; Jayaram, Lakshmi; Patel, Prahladbhai N.; Neill, Patrick J. O’; Komenaka, Ian K.

doi:10.1016/j.ijscr.2015.02.051

Cited by 15 publications

(11 citation statements)

References 17 publications

(28 reference statements)

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“…Whether to undergo wide local excision were finally decided according to the recovery condition after the above treatments. Patients with hyperprolactinemia received oral bromocriptine for 3 months after surgery as medical management of hyperprolactinemia has been proven to be correlated with resolution of IGM (16,17). Fasting prolactin (PRL) level was examined after patients sitting quietly for at least half an hour.…”

Section: Subjectsmentioning

confidence: 99%

A retrospective analysis of recurrence risk factors for granulomatous lobular mastitis in 130 patients: more attention should be paied to prolactin level

Huang¹,

Wu²

2021

Ann Palliat Med

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Background: Granulomatous lobular mastitis (GLM) is a benign chronic inflammatory breast disease with indecisive etiology and easy recurrence, and seriously affects physical and mental health of women. This study aims to discover the factors associated with the recurrence of GLM and provide some new thoughts for the treatment.Methods: We retrospectively collected clinical data of GLM patients from January 2010 to June 2019.Patients were divided into no recurrence group (group A) and recurrence group (group B). Demographic data and clinical features were compared in two groups.Results: There were 103 (79.23%) patients in group A and 27 (20.77%) in group B. In univariate analysis, body mass index (BMI), the difference of prolactin (PRL) level before and after treatment and follicle-stimulating hormone (FSH)/luteinizing hormone (LH) were associated with the recurrence of GLM. Moreover, the difference of PRL level before and after treatment was the independent risk factor of recurrence and patients presenting with higher PRL after treatment than before treatment had a higher risk of recurrence [odds ratio (OR) 21.405, 95% confidence interval (CI): 1.702-269.233, P=0.018].

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Section: Subjectsmentioning

confidence: 99%

A retrospective analysis of recurrence risk factors for granulomatous lobular mastitis in 130 patients: more attention should be paied to prolactin level

Huang¹,

Wu²

2021

Ann Palliat Med

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“…Methotrexate (MTX) is used alone or in combination with steroids. Besides, bromocriptine and cabergoline are also used [7-9]. There are studies recommending surgical approach alone [10].…”

Section: Introductionmentioning

confidence: 99%

Low-Dose Methotrexate Use in Idiopathic Granulomatous Mastitis: An Alternative Treatment Method

Kafadar

Bahadır

Gırgın³

2021

Breast Care

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Background: Idiopathic granulomatous mastitis (IGM) is a rare, recurrent and progressive breast disease with an unknown etiology. Patients with IGM will probably face stressful, time-consuming treatment procedures with side effects due to medications. There are different treatment modalities in clinical use including medical and surgical interventions. Objective: The aim of this study was to present the results of using the combination therapy of low-dose methotrexate (MTX) and steroid in IGM. Methods: Seventeen patients diagnosed with IGM and treated with MTX were included into the study. Low-dose MTX at 5 mg/week and 8 mg/day prednisone were given for 2–3 months. Results: After 2–3 months of treatment, 10 patients exhibited (58.5%) complete, 3 patients (17.6%) partial recovery, and no response to the treatment process was observed in 4 patients (23.5%). No side effects of MTX and recurrent events were noted in any of the patients. Conclusion: Low-dose MTX and prednisone treatment for IGM patients, who did not respond to steroids alone, should be considered as an alternative treatment method instead of surgical intervention.

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“…Local and systemic corticosteroids and antibiotics are the most frequently used agents in the medical treatment. However, successful results have been reported with agents, such as methotrexate, azathioprine, glucocorticoids, bromocriptine and colchicine . Surgical treatment of IGM includes abscess drainage, local and wide excisions, or mastectomy.…”

Section: Introductionmentioning

confidence: 99%

Factors related to recurrence of idiopathic granulomatous mastitis: what do we learn from a multicentre study?

Uysal

Soran

Sezgın

2017

ANZ Journal of Surgery

100

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Temporal resolution of idiopathic granulomatous mastitis with resumption of bromocriptine therapy for prolactinoma

Abstract: HighlightsIGM is becoming recognized more frequently.Observation and patients with the natural history can be effective management.Prolactin may be involved in the pathophysiology of IGM.

Cited by 15 publications

References 17 publications

A retrospective analysis of recurrence risk factors for granulomatous lobular mastitis in 130 patients: more attention should be paied to prolactin level

A retrospective analysis of recurrence risk factors for granulomatous lobular mastitis in 130 patients: more attention should be paied to prolactin level

Low-Dose Methotrexate Use in Idiopathic Granulomatous Mastitis: An Alternative Treatment Method

Factors related to recurrence of idiopathic granulomatous mastitis: what do we learn from a multicentre study?

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