2019
DOI: 10.1002/dvdy.87
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Temporal regulation of Lin28a during mammalian neurulation contributes to neonatal body size control

Abstract: Background The timing of developmental events is tightly regulated along a time axis for normal development. Although the RNA‐binding protein Lin28a plays a crucial role in the regulation of developmental timing in Caenorhabditis elegans, how the timing of Lin28a expression affects the rate and/or duration of developmental events during mammalian development remains to be addressed. Results In this study, we discovered that the timing and the duration of Lin28a expression affect embryonic growth. During the ne… Show more

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Cited by 5 publications
(5 citation statements)
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References 27 publications
(56 reference statements)
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“…This analysis revealed 151 conserved differentially expressed genes (Figure 4D), 90% of which displayed the same direction of regulation in both mutants (Figure 4E). 63 of the 136 co-regulated genes were up-regulated, including genes enriched in NMPs ( Nkx1-2 , Epha5, Gpm6a and Gldc ) (Gouti et al, 2017) , as well as genes known to promote axial elongation such as Lin28a , Lin28b (Aires et al, 2019; Miyazawa et al, 2019; Robinton et al, 2019). On the other hand, 73 of the 136 co-regulated genes were down-regulated and included many posterior Hox genes, supporting an antagonistic arrangement whereby Nr6a1 promotes and Gdf11 terminates a core trunk gene regulatory network.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…This analysis revealed 151 conserved differentially expressed genes (Figure 4D), 90% of which displayed the same direction of regulation in both mutants (Figure 4E). 63 of the 136 co-regulated genes were up-regulated, including genes enriched in NMPs ( Nkx1-2 , Epha5, Gpm6a and Gldc ) (Gouti et al, 2017) , as well as genes known to promote axial elongation such as Lin28a , Lin28b (Aires et al, 2019; Miyazawa et al, 2019; Robinton et al, 2019). On the other hand, 73 of the 136 co-regulated genes were down-regulated and included many posterior Hox genes, supporting an antagonistic arrangement whereby Nr6a1 promotes and Gdf11 terminates a core trunk gene regulatory network.…”
Section: Resultsmentioning
confidence: 99%
“…However, Gdf11 signalling has pleiotropic effects across the vertebral column, with patterning changes as far anterior as the cervical region as well as tail truncation observed in Gdf11 -/- mice (McPherron et al, 1999). It is currently unclear whether the cell-intrinsic mechanisms downstream of Gdf11 signalling are common across all phenotypes, though axially-restricted effectors such as Pou5f1/Oct4 in the trunk (Aires et al, 2016), and the Lin28- let7 axis in the tail (Aires et al, 2019; Miyazawa et al, 2019; Robinton et al, 2019) have been identified.…”
Section: Introductionmentioning
confidence: 99%
“…One of these genes was the Lin28a gene, a well-known RNA-binding protein. Previous studies have shown that Lin28a affects developmental events during neurulation in mice (Miyazawa et al, 2019) and contributes to the regeneration of exhausted Sox2 progenitors in mammals. Therefore, it may perform a certain function in neurodevelopment.…”
Section: Human Foxm1 Regulates Neurogenesis By Targeting Lin28amentioning
confidence: 99%
“…5F). 63 of the 136 co-regulated genes were upregulated, including genes enriched in NMPs (Nkx1-2, Epha5, Gpm6a and Gldc) 20 , as well as genes known to promote axial elongation such as Lin28a, Lin28b [27][28][29] . On the other hand, 73 of the 136 co-regulated genes were downregulated and included many posterior Hox genes, supporting an antagonistic arrangement whereby Nr6a1 promotes and Gdf11 terminates a core trunk gene regulatory network.…”
Section: Opposing Effects Of Nr6a1 and Gdf11 On A Trunk Regulatory Mo...mentioning
confidence: 99%
“…However, Gdf11 signalling has pleiotropic effects across the vertebral column, with patterning changes as far anterior as the cervical region as well as tail truncation observed in Gdf11 −/− mice 22 . It is currently unclear whether the cell-intrinsic mechanisms downstream of Gdf11 signalling are common across all phenotypes, though axially-restricted effectors such as Pou5f1/Oct4 in the trunk 26 , and the Lin28-let7axis in the tail [27][28][29] have been identified.…”
mentioning
confidence: 99%