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2016
DOI: 10.6061/clinics/2016(07)10
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Temporal profile of intestinal tissue expression of intestinal fatty acid-binding protein in a rat model of necrotizing enterocolitis

Abstract: OBJECTIVES:Necrotizing enterocolitis is a severe multifactorial intestinal disorder that primarily affects preterm newborns, causing 20-40% mortality and morbidity. Intestinal fatty acid-binding protein has been reported to be a biomarker for the detection of intestinal injuries. Our aim was to assess intestinal tissue injury and the molecular expression of intestinal fatty acid-binding protein over time in a necrotizing enterocolitis model.METHODS:A total of 144 Newborn rats were divided into two groups: 1) C… Show more

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Cited by 6 publications
(9 citation statements)
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“…NEC is characterized by ischemic necrosis of gastrointestinal tract and intestinal perforation. The pathogenesis involves intestinal hypoxia-ischemia, immature intestinal development, microbial reproduction and high immune response of intestinal mucosa ( 13 , 14 ). I-FABP is mainly distributed in villus cells in intestinal mucosa, which can be quickly released when intestinal ischemic injury occurs, enters the blood circulation through the cell membranes, capillaries, lymphatic capillaries and portal veins, and is finally discharged with urine from the body ( 15 ).…”
Section: Discussionmentioning
confidence: 99%
“…NEC is characterized by ischemic necrosis of gastrointestinal tract and intestinal perforation. The pathogenesis involves intestinal hypoxia-ischemia, immature intestinal development, microbial reproduction and high immune response of intestinal mucosa ( 13 , 14 ). I-FABP is mainly distributed in villus cells in intestinal mucosa, which can be quickly released when intestinal ischemic injury occurs, enters the blood circulation through the cell membranes, capillaries, lymphatic capillaries and portal veins, and is finally discharged with urine from the body ( 15 ).…”
Section: Discussionmentioning
confidence: 99%
“…In this regard, perinatal hypoxia, early feeding with formula milk, and bacterial colonization play a fundamental role in the activation of the inflammatory cascade of NEC. These factors induce intestinal damage, which may progress to coagulative necrosis of the gastrointestinal tract 1,3 .…”
Section: Use Of Sildenafil and L-arginine In An Experimental Rat Mode...mentioning
confidence: 99%
“…2 Pediatric Surgery Department, Federal University of Parana, Curitiba, R. Gen. Carneiro, 181 -Alto da Glória, Curitiba, PR 80060-900, Brazil. 3 Biochemistry Department, Federal University of Parana Campus Polytechnic Center, Curitiba, Jardim das Américas, Curitiba, PR 80050-540, Brazil. 4 www.nature.com/scientificreports/ signaling within the endothelium with reduced blood flow and impaired eNOS function, Yazji et al 4 evaluated the supplementation of the phosphodiesterase-5 inhibitor, sildenafil, in wild-type mice and observed a reduction in the severity of NEC, through vasodilation and maintenance of the intraluminal NO activity promoted by the substance 4 .…”
Section: Use Of Sildenafil and L-arginine In An Experimental Rat Mode...mentioning
confidence: 99%
“…Rat NEC models have also been useful in temporal biomarker studies (e.g. correlation on intestinal fatty acid binding protein with timing of ischemia and severity of tissue injury(23)). Currently, the administration of a protein kinase A inhibitor(24) and milk-derived exosomes(25) are being studied in a rat model with promising results as potential treatments for NEC.…”
Section: Modeling Nec In the Ratmentioning
confidence: 99%