Temporal lobe epilepsy surgery modulates the activity of auditory pathway

Báez-Martín, Margarita Minou; Chacón, Lilia María Morales; García-Maeso, I; Estupiñán-Díaz, Bárbara; Pedré, Lourdes Lorigados; García, María Eugenia; Galvizu, Reynaldo; Bender, J.; Cabrera-Abreu, Ivette; Pérez-Téllez, Yamila; Galán, Lı́dice

doi:10.1016/j.eplepsyres.2014.02.017

Cited by 8 publications

(11 citation statements)

References 19 publications

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“…The results of the auditory examination confirm what has been proposed in previous studies about the occurrence of long-term neuroplastic changes secondary to an indirect effect of the resection of temporal lobe structures [ 15 ]. Although our data seem to point to a possible effect of the surgery in the auditory pathway, these measures are not fully independent.…”

Section: Discussionsupporting

confidence: 88%

“…In a previous report, it described the positive correlation between the amplitude of Na and Pa waves and the resected volume in the middle temporal pole (Pearson correlation test p < 0.05, r = 0.84 and r = 0.65, respectively), especially in left temporal lobectomy patients. On the contrary, negative correlations were previously observed between the amplitude of these components and the residual indexes of the middle temporal pole (Pearson correlation test, p < 0.05, Na: r = −0.89 y Pa: r = −0.79), inferior temporal gyrus and amygdala (Pearson correlation test, p < 0.05, only Pa: r = −0.67 y r = −0.59, respectively) [ 15 ].…”

Section: Resultsmentioning

confidence: 81%

“…However, if we take into account that during the postsurgical evaluation, the amplitude analysis of the components of the MLR that were far from decreasing showed a tendency to increase at 12 and 24 months after the resection [ 15 ], we could be in the presence of a “paradoxical” phenomenon of release, characterized by a long-term functional improvement once the epileptogenic zone is removed.…”

Section: Discussionmentioning

confidence: 99%

“…In previous papers, we studied the variations of auditory and visual evoked potentials in patients with temporal lobe epilepsy that were submitted to surgical resection of the epileptogenic area [ 15 , 16 ]. Auditory brainstem response, auditory middle latency response and partial field visual evoked potentials were evaluated in particular.…”

Section: Introductionmentioning

confidence: 99%

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Relation of Structural and Functional Changes in Auditory and Visual Pathways after Temporal Lobe Epilepsy Surgery

Báez-Martín

Chacón

García-Maeso

et al. 2018

Behavioral Sciences

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Auditory and visual pathways may be affected as a consequence of temporal lobe epilepsy surgery because of their anatomical relationships with this structure. The purpose of this paper is to correlate the results of the auditory and visual evoked responses with the parameters of tractography of the visual pathway, and with the state of connectivity between respective thalamic nuclei and primary cortices in both systems after the surgical resection of the epileptogenic zone in drug-resistant epileptic patients. Tractography of visual pathway and anatomical connectivity of auditory and visual thalamus-cortical radiations were evaluated in a sample of eight patients. In general, there was a positive relationship of middle latency response (MLR) latency and length of resection, while a negative correlation was found between MLR latency and the anatomical connection strength and anatomical connection probability of the auditory radiations. In the visual pathway, significant differences between sides were found with respect to the number and length of tracts, which was lower in the operated one. Anatomical connectivity variables and perimetry (visual field defect index) were particularly correlated with the latency of P100 wave which was obtained by quadrant stimulation. These results demonstrate an indirect functional modification of the auditory pathway and a direct traumatic lesion of the visual pathway after anterior temporal lobectomy in patients with drug resistant epilepsy.

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Section: Discussionsupporting

confidence: 88%

Section: Resultsmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relation of Structural and Functional Changes in Auditory and Visual Pathways after Temporal Lobe Epilepsy Surgery

Báez-Martín

Chacón

García-Maeso

et al. 2018

Behavioral Sciences

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“…Clinically, these children may have frequent seizures, characterized by auras and impaired consciousness [44,45]. Their seizures often become resistant to high levels of drugs, requiring surgical procedures [46,47]. Moreover, their abnormal discharges often occur exactly in the region where the auditory pathway ends, which is the same region responsible for more elaborate auditory processing skills.…”

Section: Discussionmentioning

confidence: 99%

Comparison of auditory event-related potentials between children with benign childhood epilepsy with centrotemporal spikes and children with temporal lobe epilepsy

Casali

Amaral

Boscariol

et al. 2016

Epilepsy & Behavior

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The abnormal brain discharges observed in benign childhood epilepsy with centrotemporal spikes (BECTS) and temporal lobe epilepsy (TLE) are located close to areas responsible for auditory and language processing. This study aimed to analyze the results of auditory event-related potentials (P300) in children with BECTS and TLE in order to assess whether the epileptic activity in centrotemporal and temporal regions may compromise the integrity and physiology of auditory system structures. This was a prospective, comparative, and cross-sectional study. Group I (GI) consisted of 13 children diagnosed with BECTS, group II (GII), 7 children diagnosed with TLE, and control group (GIII), 16 healthy children, with no hearing or academic complaints. After neurological and basic audiological assessments, P300 was applied. The P300 latency and amplitude were compared between groups. Regarding latency, GI showed 324.1 (+31.5) ms, GII 336.3 (+23.5) ms, and GIII 318 (+27.7) ms. Amplitudes were 4.80 (+3.2) μV in GI, 4.7 (+2.5) μV in GII, and 5.8 (+2.4) μV in GIII. Although children with BECTS showed prolonged latencies and reduced amplitudes, these differences were not considered statistically significant. Children with TLE showed statistically significant prolonged P300 latency compared with the control group (P=0.037). We speculate that abnormal electrical discharges in centrotemporal and temporal regions led to the slowing of auditory processing in our sample.

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