Temporal lobe epilepsy: Decreased thalamic resting-state functional connectivity and their relationships with alertness performance

Chen, Xuemei; Huang, Duruo; Chen, Zi⁃rong; Ye, Wei; Lv, Zongxia; Zheng, Jinou

doi:10.1016/j.yebeh.2014.12.013

Cited by 25 publications

(19 citation statements)

References 53 publications

(71 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to behavioral research, rTLE patients have significantly lower intrinsic alertness and phasic alertness RTs than healthy individuals. Our results are similar to those of Cerminara et al's study (Cerminara et al, ) of childhood absence epilepsy as well as those of other previous studies (Chen et al, ; Zheng et al, ). However, we did not observe a difference in the alertness RT between patients and healthy controls.…”

Section: Discussionsupporting

confidence: 93%

“…The former represents the short‐term ability to enhance response readiness following detection of an external cue, whereas the latter refers to the internal control of arousal or wakefulness in the absence of such a cue; both can be assessed by measuring reaction times. In our previous study, we found that patients with temporal lobe epilepsy have impaired vigilance functions (Chen et al, ; Zheng et al, ). In an attention network test (ANT) task‐related functional MRI analysis, we (Zheng et al, ) found significantly weaker activation of specific brain regions (including the cerebellum, right occipital lobe, right frontal lobe, and brainstem) in TLE patients than in healthy controls.…”

Section: Introductionmentioning

confidence: 90%

“…In an attention network test (ANT) task‐related functional MRI analysis, we (Zheng et al, ) found significantly weaker activation of specific brain regions (including the cerebellum, right occipital lobe, right frontal lobe, and brainstem) in TLE patients than in healthy controls. In addition, our previous study showed that the functional connectivity (FC) between the thalamus and the anterior cingulate gyrus in patients with rTLE (Chen et al, ) was associated with vigilance, and the integrity of the resting‐state functional network was disrupted. Brain entropy is an index representing the complexity of the brain.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Resting‐state brain entropy in right temporal lobe epilepsy and its relationship with alertness

et al. 2019

View full text Add to dashboard Cite

BackgroundTo date, no functional MRI (fMRI) studies have focused on brain entropy in right temporal lobe epilepsy (rTLE) patients. Here, we characterized brain entropy (BEN) alterations in patients with rTLE using resting‐state functional MRI(rs‐fMRI) and explored the relationship between BEN and alertness.MethodThirty‐one rTLE patients and 33 controls underwent MRI scanning to investigate differences in BEN and resting‐state functional connectivity (rs‐FC) in regions of interest (ROIs) between patients and controls. Correlation analyses were performed to examine relationships between the BEN of each ROI and alertness reaction times (RTs) in rTLE patients.ResultsCompared with controls, the BEN of rTLE patients was significantly increased in the right middle temporal gyrus, inferior temporal gyrus, and other regions of the left hemisphere and significantly decreased in the right middle frontal gyrus and left supplementary motor area (p < .05). The rs‐FCs between the ROIs (at p < .01, with the left superior parietal lobule and right precentral gyrus defined as ROI1 and ROI2, respectively) and the whole brain showed an increasing trend in rTLE patients. In addition, the BEN of ROI2 was associated with the intrinsic alertness and phasic alertness RTs of patients with rTLE.ConclusionsOur findings suggest that BEN is altered in patients with rTLE and that decreased BEN in the right precentral gyrus is positively related to intrinsic and phasic alertness; the abnormal FC in the brain regions with altered entropy suggests a reconstruction of brain functional connectivity. These findings suggest that BEN mapping may provide a useful tool for probing brain mechanisms related to TLE.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Resting‐state brain entropy in right temporal lobe epilepsy and its relationship with alertness

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Our previous task-based fMRI study indicated that activation of alertness-related brain areas, such as the right occipital and right frontal lobe, was significantly attenuated in right temporal lobe epilepsy (rTLE) patients (20). Extension of resting-state functional MRI (rsfMRI) findings in rTLE patients demonstrated that decreased FC between the right thalamus, anterior cingulate cortex (ACC) (21), and right cuneus (22) was correlated with the alertness.…”

Section: Introductionmentioning

confidence: 99%

Disrupted Structural and Functional Networks and Their Correlation with Alertness in Right Temporal Lobe Epilepsy: A Graph Theory Study

Jiang

et al. 2017

Front. Neurol.

Self Cite

View full text Add to dashboard Cite

Previous studies have shown that temporal lobe epilepsy (TLE) involves abnormal structural or functional connectivity in specific brain areas. However, limited comprehensive studies have been conducted on TLE associated changes in the topological organization of structural and functional networks. Additionally, epilepsy is associated with impairment in alertness, a fundamental component of attention. In this study, structural networks were constructed using diffusion tensor imaging tractography, and functional networks were obtained from resting-state functional MRI temporal series correlations in 20 right temporal lobe epilepsy (rTLE) patients and 19 healthy controls. Global network properties were computed by graph theoretical analysis, and correlations were assessed between global network properties and alertness. The results from these analyses showed that rTLE patients exhibit abnormal small-world attributes in structural and functional networks. Structural networks shifted toward more regular attributes, but functional networks trended toward more random attributes. After controlling for the influence of the disease duration, negative correlations were found between alertness, small-worldness, and the cluster coefficient. However, alertness did not correlate with either the characteristic path length or global efficiency in rTLE patients. Our findings show that disruptions of the topological construction of brain structural and functional networks as well as small-world property bias are associated with deficits in alertness in rTLE patients. These data suggest that reorganization of brain networks develops as a mechanism to compensate for altered structural and functional brain function during disease progression.

show abstract

“…Extending the voxel-wise comparison to address the functions of the thalamocortical network, functional alterations in the thalamocortical network were found in patients with IGEs and mTLE (Kim et al, 2014, Keller et al, 2014, Chen et al, 2015). …”

Section: Introductionmentioning

confidence: 99%

Altered structural and functional thalamocortical networks in secondarily generalized extratemporal lobe seizures

Peng

Hsin

2017

NeuroImage: Clinical

View full text Add to dashboard Cite

Structural and functional abnormalities in the thalamocortical network in primary generalized epilepsies or mesial temporal lobe epilepsy have recently been identified by voxel-wise analyses of neuroimaging. However, evidence is needed regarding the profiles of the thalamocortical network in patients with secondarily generalized seizures from focal neocortical sources. We used high-resolution T1-weighted, diffusion-tensor and resting-state functional MR imaging (rs-fMRI) to examine 16 patients with secondarily generalized extratemporal lobe seizures and 16 healthy controls. All the patients were medically effective and MRI-negative. Using whole brain voxel-based morphometry (VBM) to compare the patients with the normal controls, we observed significantly decreased gray matter (GM) density in the thalamus and 3 frontal gyri and significantly reduced white matter (WM) fractional anisotropy (FA) in the bilateral anterior corona radiata of the patients. Alterations in the thalamocortical functional connectivity with different cortices were identified by the rs-fMRI analysis seeding of the whole thalamus. The prefrontal gyri with the greatest functional connectivity were also traced by seeding a sub-thalamic region that is demarcated in an atlas, in which the thalamic parcellation is based on the WM connectivity to the cortices. This sub-thalamic region anatomically contains the mediodorsal thalamic nucleus where, concordantly, there was a significant decrease in thalamic GM density in the VBM study. In contrast to the negative correlation between the disease duration and reduced thalamic densities and subcortical FA values, the strength of the functional thalamocortical connectivity had a paradoxical correlation. Our results conclusively indicate that generalized seizures with a focal cortical source are associated with structural and functional alterations in the thalamocortical network.

show abstract

Temporal lobe epilepsy: Decreased thalamic resting-state functional connectivity and their relationships with alertness performance

Cited by 25 publications

References 53 publications

Resting‐state brain entropy in right temporal lobe epilepsy and its relationship with alertness

Resting‐state brain entropy in right temporal lobe epilepsy and its relationship with alertness

Disrupted Structural and Functional Networks and Their Correlation with Alertness in Right Temporal Lobe Epilepsy: A Graph Theory Study

Altered structural and functional thalamocortical networks in secondarily generalized extratemporal lobe seizures

Contact Info

Product

Resources

About