Temporal Evaluation of Body Composition, Glucose Homeostasis and Lipid Profile of Male Rats Programmed by Maternal Protein Restriction During Lactation

Fagundes, A. T. S.; Moura, Egberto Gaspar de; Passos, M. C. F.; Santos-Silva, Ana Paula; Oliveira, Elaine de; Trevenzoli, Isis Hara; Casimiro-Lopes, Gustavo; Nogueira-Neto, José Firmino; Lisboa, Patrícia Cristina

doi:10.1055/s-0029-1233457

Cited by 42 publications

(42 citation statements)

References 25 publications

(38 reference statements)

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“…In accordance with our previous report (Fagundes et al 2009), LPHC animals had lower glycemia and insulinemia in 180-day-old rats. These findings, together with lower I/G ratio, HOMA-IR, and HOMA-b, indicate that these animals had higher insulin sensitivity.…”

Section: Discussionsupporting

confidence: 93%

“…In recent years, it has been shown that long-term ER decreases the levels of oxidative damage to cellular macromolecules mainly by reducing the rate of mitochondrial reactive oxygen species (ROS) generation in rodents (Gredilla & Barja 2005). In contrast to chronic ER, studies in rats showed that maternal ER, during lactation only, programs the adult offspring to a higher body length and weight , while maternal protein restriction seems to protect against obesity and insulin resistance (Fagundes et al 2007(Fagundes et al , 2009.…”

Section: Introductionmentioning

confidence: 99%

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Resveratrol reduces lipid peroxidation and increases sirtuin 1 expression in adult animals programed by neonatal protein restriction

Franco¹,

Moura²,

Koury³

et al. 2010

Journal of Endocrinology

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Resveratrol (Res) has been associated with protective effects against oxidative stress. This study evaluated the effect of Res over lipid peroxidation, antioxidant defense, hepatic sirtuin 1 (SIRT1), which up-regulates antioxidant enzymes, and copper/zinc superoxide dismutase (Cu/Zn SOD) in adult offspring whose mothers were protein restricted during lactation. Lactating Wistar rats were divided into control (C) group, which were fed a normal diet (23% protein), and low-protein and high-carbohydrate (LPHC) group, which were fed a diet containing 8% protein. After weaning (21 days), C and LPHC offspring were fed a normal diet until they were 180 days old. At the 160th day, animals were separated into four groups as follows: control, controlCRes, LPHC, and LPHCCRes. Resveratrol was given for 20 days (30 mg/kg per day by gavage). LPHC animals showed a higher total antioxidant capacity (TAC) without change in lipid peroxidation and SIRT1 expression. The treatment with Res increased TAC only in the control group without effect on lipid peroxidation and SIRT1. LPHC animals treated with Res had lower lipid peroxidation and higher protein and mRNA expression of SIRT1 without any further increase in TAC. No significant difference in liver Cu/Zn SOD expression was observed among the groups. In conclusion, maternal protein restriction during lactation programs the offspring for a higher antioxidant capacity, and these animals seem to respond to Res treatment with a lower lipid peroxidation and higher hepatic SIRT1 expression that we did not observe in the Res-treated controls. It is probable that the protective effect can be attributed to Res activating SIRT1, only in the LPHC-programed group.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Resveratrol reduces lipid peroxidation and increases sirtuin 1 expression in adult animals programed by neonatal protein restriction

Franco¹,

Moura²,

Koury³

et al. 2010

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…This agrees with several studies showing that early malnutrition programmes lead to the development of a thrifty phenotype (Petry et al 2000, Ozanne & Hales 2002, Plagemann 2006. Interestingly, PR mice had higher total body fat, as previously detected in PR rats of the same programming model (Fagundes et al 2007(Fagundes et al , 2009). Thus, it is possible that the lower body mass of this group is due to a loss of muscle mass.…”

Section: Discussionsupporting

confidence: 92%

“…Table I shows the composition of the diets (Reeves et al 1993). The PR diet was produced in our laboratory, using the standard commercial diet for rodents (NuvilabNuvital Nutrientes SA, PR, Brazil) by replacing parts of the protein with cornstarch (Lisboa et al 2003, de Moura et al 2007, Fagundes et al 2009). The amount of cornstarch that was added compensated for the decrease in energy content due to protein reduction.…”

Section: Methodsmentioning

confidence: 99%

The outcome of acute schistosomiasis infection in adult mice with postnatal exposure to maternal malnutrition

Corrêa

Lisboa

Oliveira

et al. 2011

Mem. Inst. Oswaldo Cruz

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“…The insulin resistance index (IRI) was calculated by the product of fasting insulin (µIU/mL) × fasting glucose (mmol/L) (Fagundes et al 2009, Lima Nda et al 2011, Li et al 2012.…”

Section: Plasmatic Parametersmentioning

confidence: 99%

HPA axis and vagus nervous function are involved in impaired insulin secretion of MSG-obese rats

Miranda

Torrezan

Oliveira

et al. 2016

Journal of Endocrinology

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Neuroendocrine dysfunctions such as the hyperactivity of the vagus nerve and hypothalamus–pituitary–adrenal (HPA) axis greatly contribute to obesity and hyperinsulinemia; however, little is known about these dysfunctions in the pancreatic β-cells of obese individuals. We used a hypothalamic-obesity model obtained by neonatal treatment with monosodiuml-glutamate (MSG) to induce obesity. To assess the role of the HPA axis and vagal tonus in the genesis of hypercorticosteronemia and hyperinsulinemia in an adult MSG-obese rat model, bilateral adrenalectomy (ADX) and subdiaphragmatic vagotomy (VAG) alone or combined surgeries (ADX–VAG) were performed. To study glucose-induced insulin secretion (GIIS) and the cholinergic insulinotropic process, pancreatic islets were incubated with different glucose concentrations with or without oxotremorine-M, a selective agonist of the M3muscarinic acetylcholine receptor (M3AChR) subtype. Protein expression of M3AChR in pancreatic islets, corticosteronemia, and vagus nerve activity was also evaluated. Surgeries reduced 80% of the body weight gain. Fasting glucose and insulin were reduced both by ADX and ADX–VAG, whereas VAG was only associated with hyperglycemia. The serum insulin post-glucose stimulation was lower in all animals that underwent an operation. Vagal activity was decreased by 50% in ADX rats. In the highest glucose concentration, both surgeries reduced GIIS by 50%, whereas ADX-VAG decreased by 70%. Additionally, M3AChR activity was recovered by the individual surgeries. M3AChR protein expression was reduced by ADX. Both the adrenal gland and vagus nerve contribute to the hyperinsulinemia in the MSG model, although adrenal is more crucial as it appears to modulate parasympathetic activity and M3AChR expression in obesity.

show abstract

Temporal Evaluation of Body Composition, Glucose Homeostasis and Lipid Profile of Male Rats Programmed by Maternal Protein Restriction During Lactation

Cited by 42 publications

References 25 publications

Resveratrol reduces lipid peroxidation and increases sirtuin 1 expression in adult animals programed by neonatal protein restriction

Resveratrol reduces lipid peroxidation and increases sirtuin 1 expression in adult animals programed by neonatal protein restriction

The outcome of acute schistosomiasis infection in adult mice with postnatal exposure to maternal malnutrition

HPA axis and vagus nervous function are involved in impaired insulin secretion of MSG-obese rats

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