Temporal dispersion in demyelination of POEMS syndrome and Castleman disease

Comparison between nerve conduction study and high-resolution ultrasonography with color doppler in type 1 and type 2 leprosy reactions

“…These NCS features of IA were shown in the classical model of inflammatory polyneuropathies, including chronic inflammatory demyelinating polyradiculopathy (CIDP) ( Van den Bergh et al, 2010 ). Such signs of segmental demyelination are also observed in acute or subacute nerve inflammatory injuries and can be used as signs of subacute IA ( Garbino et al, 2010 , Lau et al, 2020 , Tankisi et al, 2005 ). Recently, studies utilizing high-frequency ultrasound with color Doppler (HFUS with CD) in leprosy neuropathy have described characteristic changes in leprosy neuropathy ( Gonzalez and Hobson-Webb, 2019 , Martinoli et al, 2000 ), thus facilitating diagnosis and treatment.…”

Two cases of special POEMS syndrome without monoclonal protein expression: a case report and literature review

“…Detailed electrophysiological analysis of the duration of distal compound muscle action potentials may help to distinguish between POEMS syndrome and Castleman disease. 13 Amyloidosis was also ruled out based on skin and rectum biopsy findings.…”

The Importance of Being Significant: “Monoclonal Gammopathies of Neurological Significance”

“…Mani et al also described several electrophysiological features that can aid in differentiating POEMS and IgM MGUS from other types of PPNs, some of which had been previously described. (7,8,9) The outcome measures in their study were response to therapy and residual neurologic disability. Majority of the patients were stabilized with standard therapies (65.3%), while only a smaller number of patients showed improvement (30.6%).…”