The Importance of Being Significant: “Monoclonal Gammopathies of Neurological Significance”

Sadeghian, Hamid

doi:10.1017/cjn.2021.20

Cited by 1 publication

(1 citation statement)

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“…Clinicians should be aware of them because neuropathies frequently co-occur with them. When neuropathy is the presenting feature, neurologists have a special responsibility because they may find clinical, laboratory, radiologic, electrodiagnostic, or biopsy findings that may identify the underlying paraproteinemia [1][2][3]. Between the various paraproteinemias, there are considerable differences in the prevalence of neuropathies in these patients and the degree to which they predominate the clinical picture.…”

Section: Introductionmentioning

confidence: 99%

Case report of Paraproteinemia

DC¹,

Pramod²,

Prabhash³

et al. 2022

World J. Adv. Res. Rev.

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Different peripheral neuropathies are linked to paraproteinemia. Anti-myelin-associated glycoprotein (MAG) neuropathy, immunoglobulin or its fragment deposition in the interstitium, immunoglobulin light chain amyloidosis (AL amyloidosis) and paraneoplastic mechanisms that cannot be solely attributed to immunoglobulin or its fragment deposition, represented by polyneuropathy, organotypic, are the three main causes of neuropathy correlated with paraproteinemia. Nerve conduction metrics slow down in patients with POEMS syndrome and anti-MAG neuropathy. An approximately (3.2%) of people over the age of 45-50 have paraproteins in their bodies. Plasma cell diseases can be thought of as a continuum of illnesses ranging from asymptomatic myeloma to symptomatic monoclonal gammopathy of unknown significance (MGUS). A low amount of paraprotein (30 g/L), a low percentage of plasma cells in the bone marrow, and the absence of organ or tissue damage from myeloma are the characteristics of MGUS (predominantly renal, skeletal or bone marrow impairment.) No treatment is necessary for MGUS, and there is a 1% annual risk.

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Section: Introductionmentioning

confidence: 99%