Temporal Differences in Granulosa Cell Specification in the Ovary Reflect Distinct Follicle Fates in Mice1

Mork, Lindsey; Maatouk, Danielle M.; McMahon, Jill A.; Guo, Jin Jin; Zhang, Pumin; McMahon, Andrew P.; Capel, Blanche

doi:10.1095/biolreprod.111.095208

Cited by 227 publications

(160 citation statements)

References 45 publications

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“…These cells may come from either the ovarian surface, or from those cells immediately underlying the surface, all of which are derived from GREL cells, at least in the bovine ovary (Hummitzsch et al 2013). A similar source of pre-granulosa cells in the mouse ovary has been suggested (Mork et al 2012). This study, while in general agreement with the concepts proposed here -concluding that most if not all granulosa cells are derived from the surface epithelium -adds another level of complexity to the issue.…”

Section: Ovigerous Cord Formationmentioning

confidence: 98%

Development of mammalian ovary

Smith¹,

Wilhelm²,

Rodgers³

2014

Journal of Endocrinology

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Pre-natal and early post-natal ovarian development has become a field of increasing importance over recent years. The full effects of perturbations of ovarian development on adult fertility, through environmental changes or genetic anomalies, are only now being truly appreciated. Mitigation of these perturbations requires an understanding of the processes involved in the development of the ovary. Herein, we review some recent findings from mice, sheep, and cattle on the key events involved in ovarian development. We discuss the key process of germ cell migration, ovigerous cord formation, meiosis, and follicle formation and activation. We also review the key contributions of mesonephric cells to ovarian development and propose roles for these cells. Finally, we discuss polycystic ovary syndrome, premature ovarian failure, and pre-natal undernutrition; three key areas in which perturbations to ovarian development appear to have major effects on post-natal fertility.

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Section: Ovigerous Cord Formationmentioning

confidence: 98%

Development of mammalian ovary

Smith¹,

Wilhelm²,

Rodgers³

2014

Journal of Endocrinology

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“…After birth, the testis cords develop into the seminiferous tubules associated with active spermatogenesis, while in the ovary the ovarian cyst breaks down into each individual primordial follicle, an oocyte surrounded by a single layer of granulosa cells. A part of the primordial follicle continuously grows into primary and subsequent secondary follicle stages at the medullary side during the initial round of folliculogenesis (Mork et al 2012, Harikae et al 2013b.…”

Section: Introductionmentioning

confidence: 99%

A novel Amh-Treck transgenic mouse line allows toxin-dependent loss of supporting cells in gonads

Shinomura¹,

Kishi²,

Tomita³

et al. 2014

Reproduction

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Cell ablation technology is useful for studying specific cell lineages in a developing organ in vivo. Herein, we established a novel anti-Mü llerian hormone (AMH)-toxin receptor-mediated cell knockout (Treck) mouse line, in which the diphtheria toxin (DT) receptor was specifically activated in Sertoli and granulosa cells in postnatal testes and ovaries respectively. In the postnatal testes of Amh-Treck transgenic (Tg) male mice, DT injection induced a specific loss of the Sertoli cells in a dose-dependent manner, as well as the specific degeneration of granulosa cells in the primary and secondary follicles caused by DT injection in Tg females. In the testes with depletion of Sertoli cell, germ cells appeared to survive for only several days after DT treatment and rapidly underwent cell degeneration, which led to the accumulation of a large amount of cell debris within the seminiferous tubules by day 10 after DT treatment. Transplantation of exogenous healthy Sertoli cells following DT treatment rescued the germ cell loss in the transplantation sites of the seminiferous epithelia, leading to a partial recovery of the spermatogenesis. These results provide not only in vivo evidence of the crucial role of Sertoli cells in the maintenance of germ cells, but also show that the Amh-Treck Tg line is a useful in vivo model of the function of the supporting cell lineage in developing mammalian gonads.

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“…The embryonic origin of these cells is unclear, likely candidate precursor cells being those of the rete ovarii (Byskov & Lintern-Moore 1973, Zamboni et al 1979 or the surface epithelium . It is also possible that granulosa cells may derive in separate waves from both these populations (Eppig & Handel 2012, Mork et al 2012. The first wave supplying the pre-granulosa cells for follicles developing within the medulla while the second wave is associated with follicles developing in the cortex.…”

Section: Morphology Of the Gonadal Ridge And The Developing Ovarymentioning

confidence: 99%

“…The first wave supplying the pre-granulosa cells for follicles developing within the medulla while the second wave is associated with follicles developing in the cortex. Granulosa cell origins may also vary between species , Mork et al 2012. No SF development was observed in fetus 1.…”

Section: Morphology Of the Gonadal Ridge And The Developing Ovarymentioning

confidence: 99%

Development of the germinal ridge and ovary in the African elephant (Loxodonta africana)

et al. 2012

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The follicular reserve and its ontogeny in the elephant are of interest because elephants have the longest reproductive life of all landbased mammals. They also have the longest recorded pregnancy, which allows a protracted view of the series of significant events involved in the development of the embryonic and fetal gonads. The large elephant population of Zimbabwe provided the opportunity to collect conceptuses from elephants culled for management reasons and hunted professionally. Five embryos aged 76-96 days and the ovaries of four fetuses aged 4.8-11.2 months were fixed in 4% buffered formalin and studied by conventional histological sectioning and a stereological protocol to calculate the follicle reserve of each fetus. These observations enabled the conclusion that the migration of primordial germ cells into the indifferent gonad terminates at around 76 days of gestation while entry of oogonia into meiosis along with first follicle formation starts at around 5 months. Peak numbers of follicles are present by mid-gestation towards the end of the 6-month mitotic-meiotic transition period. It appears that the cortex of the elephant fetal ovary at mid-gestation (11 months) has already reached a developmental stage exhibited by the ovaries of many other mammals at full term.

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Temporal Differences in Granulosa Cell Specification in the Ovary Reflect Distinct Follicle Fates in Mice1

Cited by 227 publications

References 45 publications

Development of mammalian ovary

Development of mammalian ovary

A novel Amh-Treck transgenic mouse line allows toxin-dependent loss of supporting cells in gonads

Development of the germinal ridge and ovary in the African elephant (Loxodonta africana)

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