Development of mammalian ovary

Smith, Peter; Wilhelm, Dagmar; Rodgers, Ray

doi:10.1530/joe-14-0062

Cited by 83 publications

(63 citation statements)

References 78 publications

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“…Most of the growing follicles (99.9%) are destined to become atretic, and the rest will ovulate [28]. Around the end of the first postantal week, some secondary follicles are present in the mice ovary [29].…”

Section: The Role Of Androgens and Estrogens In The Ovarian Developmentmentioning

confidence: 99%

Endocrine Active Compounds Actions during Neonatal Period: Effect on the Ovary

Słomczyńska¹,

Grzesiak²,

Stwora³

2018

Selected Topics in Neonatal Care

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Many female reproductive disorders observed during adulthood originate from the neonatal period, which is a critical stage toward the reproductive potency. Human and animal fertility are determined by the pool of primordial follicles that are established during fetal or neonatal life. The earliest stages of follicle development are under control of a variety of factors, including sex steroids. Neonatal period is a "critical developmental window" in which organisms are susceptible to the environmental chemicals that may affect the reproductive health. Endocrine active compounds (EACs) are found abundantly in the environment and interfere with sex steroids (predominantly androgens and estrogens) by either mimicking or blocking their functions. This review covers the current knowledge about the effects of selected EACs with androgenic (testosterone propionate), anti-androgenic (flutamide), estrogenic (diethylstilbestrol, bisphenol A, 4-tert-octylphenol, phtalates and genistein), anti-estrogenic (ICI 182,780 and parabens), or mixed activity (methoxychlor) on the ovary of neonates, focusing on their effects on the early stages of folliculogenesis. These chemicals have been shown to affect oocyte survival, follicle formation, and growth, as well as steroidogenic functions. The better cognition of mechanisms underlying the long-term consequences of the neonatal EACs exposure may in future lead to an understanding of human health risks and developing prevention strategies.

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Section: The Role Of Androgens and Estrogens In The Ovarian Developmentmentioning

confidence: 99%

Endocrine Active Compounds Actions during Neonatal Period: Effect on the Ovary

Słomczyńska¹,

Grzesiak²,

Stwora³

2018

Selected Topics in Neonatal Care

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“…By 16.5 dpc, the male gonad contains seminiferous tubules as seen in the histological section and a defined vasculature with a prominent coelomic vessel (arrows) as seen in the whole mount stained testis with the epididymis (E) attached. Ovaries at 14.5 dpc as shown in histological section and at 16.5 dpc with whole mount staining both lack all male-specific vascular structures and instead surface epithelial cells at 10-11.5 dpc in mice (days of gestation 30-50 for cattle and 22-38 for sheep) differentiate into the Gonad Ridge Epithelial-Like (GREL) cells (Smith et al 2014). Based on data primarily from sheep and bovine models, mesonephric stromal cells, endothelial cells, and the GREL cells all migrate into the developing ovary after sex specification, but this process has not been definitively shown in rodent models (Hummitzsch et al 2013;Smith et al 2014).…”

Section: The Timing Of Mesonephric Cell Migration and Initialmentioning

confidence: 99%

“…Ovaries at 14.5 dpc as shown in histological section and at 16.5 dpc with whole mount staining both lack all male-specific vascular structures and instead surface epithelial cells at 10-11.5 dpc in mice (days of gestation 30-50 for cattle and 22-38 for sheep) differentiate into the Gonad Ridge Epithelial-Like (GREL) cells (Smith et al 2014). Based on data primarily from sheep and bovine models, mesonephric stromal cells, endothelial cells, and the GREL cells all migrate into the developing ovary after sex specification, but this process has not been definitively shown in rodent models (Hummitzsch et al 2013;Smith et al 2014). The key sex-specific differences are the relatively disorganized mesonephric migration of the developing XX gonad and that the processes are regulated by different signaling pathways (Ungewitte and Yao 2013).…”

Section: The Timing Of Mesonephric Cell Migration and Initialmentioning

confidence: 99%

Mesonephric Cell Migration into the Gonads and Vascularization Are Processes Crucial for Testis Development

Romereim

Cupp

2016

Results and Problems in Cell Differentiation

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Testis morphogenesis requires the integration and reorganization of multiple cell types from several sources, one of the more notable being the mesonephric-derived cell population. One of the earliest sex-specific morphogenetic events in the gonad is a wave of endothelial cell migration from the mesonephros that is crucial for (1) partitioning the gonad into domains for testis cords, (2) providing the vasculature of the testis, and (3) signaling to cells both within the gonad and beyond it to coordinately regulate testis development. In addition to endothelial cell migration, there is evidence that precursors of peritubular myoid cells migrate from the mesonephros, an event which is also important for testis cord architecture. Investigation of the mesonephric cell migration event has utilized histology, lineage tracing with mouse genetic markers, and many studies of the signaling molecules/pathways involved. Some of the more well-studied signaling molecules involved include vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and neurotrophins. In this chapter, the morphogenetic events, relevant signaling pathways, mechanisms underlying the migration, and the role of the migratory cells within the testis will be discussed. Overall, the migration of mesonephric cells into the early testis is indispensable for its development and future functionality.

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“…As the only source of mature oocytes, the primordial follicle pool determines the reproductive life of a female mammal (Burgoyne & Baker 1981. However, the mechanism leading to a successful establishment of a primordial follicle pool is still unclear (Smith et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Gap junctions are essential for murine primordial follicle assembly immediately before birth

Teng

Wang

et al. 2016

Reproduction

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The reserve of primordial follicles determines the reproductive ability of the female mammal over its reproductive life. The primordial follicle is composed of two types of cells: oocytes and surrounding pre-granulosa cells. However, the underlying mechanism regulating primordial follicle assembly is largely undefined. In this study, we found that gap junction communication (GJC) established between the ovarian cells in the perinatal mouse ovary may be involved in the process. First, gap junction structures between the oocyte and surrounding pre-granulosa cells appear at about 19.0 dpc (days post coitum). As many as 12 gap junction-related genes are upregulated at birth, implying that a complex communication may exist between ovarian cells, because specifically silencing the genes of individual gap junction proteins, such as Gja1, Gja4 or both, has no influence on primordial follicle assembly. On the other hand, non-specific blockers of GJC, such as carbenoxolone (CBX) and 18a-glycyrrhetinic acid (AGA), significantly inhibit mouse primordial follicle assembly. We proved that the temporal window for establishment of GJC in the fetal ovary is from 19.5 dpc to 1 dpp (days postpartum). In addition, the expression of ovarian somatic cell (OSC)-specific genes, such as Notch2, Foxl2 and Irx3, was negatively affected by GJC blockers, whereas oocyte-related genes, such as Ybx2, Nobox and Sohlh1, were hardly affected, implying that the establishment of GJC during this period may be more important to OSCs than to oocytes. In summary, our results indicated that GJC involves in the mouse primordial follicle assembly process at a specific temporal window that needs Notch signaling cross-talking.

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Development of mammalian ovary

Cited by 83 publications

References 78 publications

Endocrine Active Compounds Actions during Neonatal Period: Effect on the Ovary

Endocrine Active Compounds Actions during Neonatal Period: Effect on the Ovary

Mesonephric Cell Migration into the Gonads and Vascularization Are Processes Crucial for Testis Development

Gap junctions are essential for murine primordial follicle assembly immediately before birth

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