Temporal changes in PCB and DDE levels among a cohort of frequent and infrequent consumers of Great Lakes sportfish

Knobeloch, Lynda; Turyk, Mary E.; Imm, Pamela; Schrank, Candy S.; Anderson, Henry A.

doi:10.1016/j.envres.2008.08.010

Cited by 36 publications

(40 citation statements)

References 17 publications

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“…PCBs are highly lipophilic and bioaccumulate in fish including commonly consumed predator species such as walleye, bass, and salmon (Carlson and Swackhamer, 2006;Gewurtz et al, 2011). After PCB use and manufacture was banned in the United States in 1977, direct environmental exposure of humans decreased (Hu et al, 2011;Knobeloch et al, 2008). However, exposure via consumption of fish from contaminated waters remains a concern.…”

Section: Introductionmentioning

confidence: 97%

Trends of PCB concentrations in Lake Michigan coho and chinook salmon, 1975–2010

Rasmussen

Schrank

Williams

2014

Journal of Great Lakes Research

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The manufacture and use of polychlorinated biphenyls (PCBs) was banned in the United States in 1977 after it was determined that these compounds adversely affect animals and humans. The Wisconsin Department of Natural Resources has quantified total PCB concentrations in Lake Michigan chinook (n = 765) and coho (n = 393) salmon (Oncorhynchus tshawytscha and Oncorhynchus kisutch, respectively) filets since 1975. We analyzed these data to estimate trends in PCB concentrations in these fish . We used generalized linear models with a gamma error distribution and log link fit to the untransformed concentrations. Trend patterns were examined using graphical smoothing and generalized additive models. We identified a candidate set of models that included time trend and other predictor variables. Using the Akaike Information Criterion to select among models we found the best models for both species included piecewise linear time trends, total body length, % lipid, and collection season as predictor variables. The intersection of the two trends was 1985 for chinook salmon and 1984 for coho salmon. PCB concentrations in both species increased with body length and % lipid, and were higher for individuals caught in the fall. Our data reveals a dramatic decline in PCB concentrations of −16.7% and − 23.9% per year for chinook and coho, respectively, up until the intersection year likely reflecting implementation of restrictions on Aroclor-based PCBs. After the intersection year to 2010, PCB concentrations declined at an annual rate of −4.0% (95% CI: −4.4% to −3.6%) and −2.6% (95% CI: −3.3% to −1.9%) for chinook and coho, respectively.

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Section: Introductionmentioning

confidence: 97%

Trends of PCB concentrations in Lake Michigan coho and chinook salmon, 1975–2010

Rasmussen

Schrank

Williams

2014

Journal of Great Lakes Research

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“…Therefore, humans continue to be exposed to different organochlorine pesticides, at background levels and via direct routes of intake (ingestion, inhalation, intrauterine transmission, etc. ) (WHO 2003, Alegria et al 2008, Grandjean et al 2008, Knobeloch et al 2009, Lignell et al 2009, Herrero et al 2011, Matsumoto et al 2014. Environmental exposure to organochlorine pesticides is caused by permanent volatilization and consumption of polluted food, which tends to have small daily variations; these concentrations are indicators of a chronic exposure.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Organochlorine Pesticide Levels Between Human Blood Serum and Adipose Tissue

Martínez-Valenzuela

Waliszewski

Gómez‐Arroyo

et al. 2017

Rev. Int. Contam. Ambie.

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The organochlorine pesticides, being lipophilic compounds, show extremely high thermodynamic stability and resistance to degradation processes in the environment and in living organisms. They accumulate in lipid rich tissues and distribute between transport compartment (blood) and store compartment (adipose tissue). The purpose of this study is to make a comparison between organochlorine pesticide levels in blood serum and adipose tissue and calculate the differences in their concentrations based on routine biomonitoring study. One hundred and twenty six pair samples of adipose tissue and blood serum during autopsies as a case study were taken and analyzed in Los Mochis Sinaloa, México. Among organochlorine pesticides, higher concentrations correspond to b-HCH, pp'DDE and op'DDT in blood serum lipids; and pp'DDT shows higher concentrations in adipose tissue. Using statistical comparisons, we found a significant linear association of lipid serum organochlorine pesticide concentrations with that in adipose tissue. This concludes that serum lipid organochlorine pesticide concentrations represent an important indicator for both human biological matrices.Palabras clave: plasma, tejido graso, toxicocinética, matrices biológicas 394organismos vivos. Se acumulan en tejidos ricos en lípidos y se distribuyen entre el compartimento de transporte (sangre) y el compartimento de almacenamiento (tejido adiposo). El objetivo de este estudio fue comparar los niveles de plaguicidas organoclorados en suero sanguíneo y tejido adiposo, así como calcular sus diferencias en concentraciones en ambas matrices biológicas, tomando como base un estudio rutinario de biomonitoreo. Ciento veintiséis pares de muestras de suero sanguíneo y tejido adiposo fueron tomadas durante autopsias y analizadas como estudios de caso en Los Mochis, Sinaloa México. Entre las concentraciones más altas de plaguicidas organoclorados en lípidos de suero sanguíneo, se encuentra el b-HCH, pp´DDE y op´DDT, mientras que en el tejido adiposo el insecticida organoclorado pp'DDT reveló mayor concentración. Aplicando comparaciones estadísticas, se calculó una asociación lineal significativa entre las concentraciones de plaguicidas organoclorados en lípidos del suero sanguíneo comparandas con las del tejido adiposo. Esto permite concluir que las concentraciones de plaguicidas organoclorados en los lípidos del suero sanguíneo, representan un importante indicador para ambas matrices biológicas humanas.

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“…This proves the role of bioaccumulation as another risky exposure source to humans that could be difficult to deal with. Some contrasting findings have however been reported in the great lakes region (Anderson et al, 2008) and supported by Knobeloch et al (2009), which was attributed to the fact that chemical concentration may decline over time depending on its persistence in the environment. The tendency of contaminants to remain in the body of organisms after long term exposure to dioxin was shown by Garabrant et al (2009), where historic exposures were found to be more important than recent ones and factors like age determines it's serum level.…”

Section: Impact On Population Levelmentioning

confidence: 87%

<b>Impact of Endocrine Disruptions on Man: The likely Causes and Effects</b>

Getso¹,

Ibrahim²

2014

Bayero J. Pure App. Sci.

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It is now common knowledge that synthetic chemicals in the environment can find access into the body of humans and wildlife, thereby mimicking the action of endogenous hormones that regulate maintenance of normal growth, metabolism and reproduction. The chemicals able to do this are known as Endocrine Disrupting Chemicals (EDCs) which come from various sources ranging from household items to synthetic products and pharmaceuticals to plant derived estrogens. Although data linking cause and effect of the EDCs is extremely rare in humans owing to the fact that ethical issues would not allow for the use of humans as experimental models, yet a growing body of literature suggests a strong link between either pre-or postnatal exposure to environmental chemicals and observed adverse health outcomes. This review intends to bring together previous efforts to ascertain the impact of EDCs on human health, the missing research link and the possible precautionary strategies. This is important considering the magnitude of the adverse risks that exposure to endocrine disruptors might cause. Also, scientific uncertainty shall not delay precautionary action in reducing exposure to these chemicals as data available indicates transgenerational effects at population level due to chronic exposure to these chemicals.

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Temporal changes in PCB and DDE levels among a cohort of frequent and infrequent consumers of Great Lakes sportfish

Cited by 36 publications

References 17 publications

Trends of PCB concentrations in Lake Michigan coho and chinook salmon, 1975–2010

Trends of PCB concentrations in Lake Michigan coho and chinook salmon, 1975–2010

Comparison of Organochlorine Pesticide Levels Between Human Blood Serum and Adipose Tissue

<b>Impact of Endocrine Disruptions on Man: The likely Causes and Effects</b>

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