Comparison of Organochlorine Pesticide Levels Between Human Blood Serum and Adipose Tissue

Martínez-Valenzuela, María del Carmen; Waliszewski, Stefan M.; Gómez‐Arroyo, Sandra; Villalobos‐Pietrini, Rafael; Calderón‐Vázquez, Carlos L.; Ortega-Martínez, Daniel; Meza, Enrique; Caba, Mario

doi:10.20937/rica.2017.33.03.03

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…It has been established that, in humans, the level of some dioxin-like PCBs, polychlorinated dioxins and furans in blood serum, when referred to the lipid fraction, sufficiently reflects its concentration in the adipose tissues of the human body [ 49 ]. Similar results have been reported for the ratio of the concentrations of some OCPs in human blood and adipose tissue samples [ 50 ]. It is known that DDT and its main metabolites described in this work are very close to PCBs and dioxins in terms of distribution coefficients and other physicochemical properties.…”

Section: Resultssupporting

confidence: 89%

“…Here, it is necessary to make a small but fundamental reservation. Since in this study we did not directly measure the concentrations of PCBs in the adipose tissues of calves, then, despite the facts presented in the cited studies [ 49 , 50 , 51 , 52 , 53 , 54 , 55 ], we formally have no right to assert that POPSH decreases their concentrations not only in the blood, but also in other tissues of the calves. This study will be accomplished in the near future, and for now, for our part, we will restrict ourselves to conclusions at the level of assumptions.…”

Section: Resultsmentioning

confidence: 84%

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Protection and Active Decontamination of Dairy Cattle Heifers against Lipophilic Toxins (PCBs) from Diet

Sotnichenko¹,

Tsis

Чабаев

et al. 2021

Toxics

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We studied the effects of a hydrophobized reversed-phase feed adsorbent in the form of a polyoctylated polysilicate hydrogel (POPSH) on productivity indicators, metabolic adaptation, and on the level of polychlorinated biphenyls (PCBs) in the blood of growing Holsteinized black-and-white heifers during the transition period. Two groups of two-month-old heifers of 20 head each were used. The experimental group received POPSH in addition to the main diet. The use of the adsorbent led to an increase in daily weight gain by 19.9% and to a decrease in the total concentration of PCB congeners found in whole blood by 40%. The greatest decrease in concentration (35–52%) was observed for tetra-, penta- and hexachlorobiphenyls. These results demonstrate the possibilities of effective protection of calves from lipophilic toxins of feed and their active decontamination.

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Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 84%

Protection and Active Decontamination of Dairy Cattle Heifers against Lipophilic Toxins (PCBs) from Diet

Sotnichenko¹,

Tsis

Чабаев

et al. 2021

Toxics

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“…Martínez-Valenzuela et al (2017a) demonstrated that serum lipid OCPs concentrations represent an important indicator for both human biological matrices [102]. The authors measured higher pesticide concentrations in 126 pair samples of adipose tissue and blood serum during autopsies from Los Mochis Sinaloa, Mexico (higher concentrations correspond to b-HCH, pp'DDE and op'DDT in blood serum lipids; and pp'DDT shows higher concentrations in adipose tissue), with a significant linear association of lipid serum organochlorine pesticide concentrations with that in adipose tissue [102].…”

Section: Biomarkers Of Exposurementioning

confidence: 99%

A Systematic Review of Studies on Genotoxicity and Related Biomarkers in Populations Exposed to Pesticides in Mexico

Sánchez-Alarcón

Milić

Kašuba

et al. 2021

Toxics

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In agricultural activities, pest control is essential, and the most effective method is the use of chemical agents that also represent an important source of exposure to potentially toxic compounds. Pesticides constitute a heterogeneous group of compounds designed specifically to control different pests. Besides measuring their levels or that of their metabolites in air, plasma, serum, blood, urine, etc., some studies reported increased DNA damage levels after occupational or environmental pesticides exposure, evidenced by several cytogenetic biomarkers such as chromosomal aberrations (CA), sister chromatid exchanges (SCE), micronuclei frequency (MN) together with other nuclear abnormalities (NA), alkaline comet assay, but also changes in oxidative stress parameters and miRNA levels. Single or combined, these techniques have also been used in genotoxic biomonitoring studies of workers occupationally exposed to pesticides in Mexico. Despite being a country with great agricultural activity and reported excessive pesticide use, genotoxic studies have been relatively few and, in some cases, contradictory. A review was made of the studies available (published until the end of 2020 on PubMed, Web of Science, Redalyc and Scielo, both in English and Spanish) in the scientific literature that evaluated occupational exposure of human samples to pesticides assessed with DNA damage and related biomarkers in Mexico.

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Nonoccupational Exposure of Agricultural Area Residents to Pesticides: Pesticide Accumulation and Evaluation of Genotoxicity

Doğanlar

Tozkır

et al. 2018

Arch Environ Contam Toxicol

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Although many studies related the toxic effects of pesticides on agricultural workers, little research has been done about agricultural area residents. The purpose of this work was to monitor the presence of pesticides, as well as their genotoxic and cytotoxic potential, in humans with blood samples collected from control and intensive agricultural areas in the Thrace region. Pesticide accumulations were determined by LC-MS/MS. Cytotoxicity and genotoxicity were analyzed by comet assay, and the effect of pesticide accumulation on oxidative stress, DNA repair, and molecular chaperone response were analyzed by qRT-PCR assays in the human blood samples. The agricultural area residents had a significantly higher concentration of pesticides than those in the control area at all three sampling times, and the total pesticide amounts were 4.3 and 10 times significantly higher in blood sampled in the pesticide use period (August 2015 and 2016, respectively) than in the nonuse period (November 2015). The results showed that the pesticide level in blood during the use period led to oxidative stress, DNA damage (mean comet length and % tail DNA), and unfolded/misfolded protein response. Particularly, in pesticide use season, difference between these parameters was found statistically significant with comparison to control. Our results indicate that individuals residing around a monoculture rice farming area comprise an at-risk group as a result of increased genotoxicity evidenced in human blood. We suggest that biological monitoring efforts should be used to control nonoccupational exposures to pesticides and thus safeguard the health of agricultural area residents.

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Comparison of Organochlorine Pesticide Levels Between Human Blood Serum and Adipose Tissue

Cited by 5 publications

References 18 publications

Protection and Active Decontamination of Dairy Cattle Heifers against Lipophilic Toxins (PCBs) from Diet

Protection and Active Decontamination of Dairy Cattle Heifers against Lipophilic Toxins (PCBs) from Diet

A Systematic Review of Studies on Genotoxicity and Related Biomarkers in Populations Exposed to Pesticides in Mexico

Nonoccupational Exposure of Agricultural Area Residents to Pesticides: Pesticide Accumulation and Evaluation of Genotoxicity

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