Temporal bone histopathology in sickle cell disease

Morgenstein, Karl M.; Manace, E D

doi:10.1288/00005537-196912000-00013

Cited by 61 publications

(26 citation statements)

References 1 publication

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“…[7][8][9]15 Given its size, this tiny organ receives a disproportionate percentage of the body's blood. 16 Ischemia of the stria vascularis, with secondary hypoxia of the organ of Corti, as a direct result of sickle cell crisis, therefore poses a significant risk to the auditory system. Interestingly, most workers have observed SNHL affecting all frequencies, 6,9,17,18 whereas significantly worse high-frequency hearing loss have been reported by some, 10,14,19 and both lower and higher frequencies by others.…”

Section: Discussionmentioning

confidence: 99%

Sensorineural hearing loss in sickle cell disease—A prospective study from Oman

Okbi¹,

Alkindi²,

Al-Abri³

et al. 2011

The Laryngoscope

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The study reveals a significant incidence of sensorineural hearing loss (SNHL) in SCD patients (36.95%), although the patients were clinically asymptomatic. The hearing loss was worse in the right ears and had a female preponderance. Also, the hearing loss was more severe at the higher frequencies, 2,000-8,000 Hz in SCD patients. HbS, HbF, or low hemoglobin levels did not discriminate SCD patients with SNHL, and the role of hemoglobin F in the cochlea is still not clear. Regular audiometric assessment should therefore be recommended in SCD patients routinely.

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Section: Discussionmentioning

confidence: 99%

Sensorineural hearing loss in sickle cell disease—A prospective study from Oman

Okbi¹,

Alkindi²,

Al-Abri³

et al. 2011

The Laryngoscope

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“…Morgenstern and Menace [8] in 1967 propagated a theory that compression of the auditory canal, by the expanded bone marrow of the petrous temporal bone could contribute to hearing loss. Ischaemic damage to the hair cells of organ of corti of the cochlear, as a result of microthrombotic occlusions in the cochlear venous system seem to be another important cause of sensorineural hearing loss.…”

Section: Discussionmentioning

confidence: 99%

Sensorineural hearing loss in Nigerian children with sickle cell disease

Mgbor

Emodi

2004

International Journal of Pediatric Otorhinolaryngology

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“…Another possible explanation could be the expansion of the temporal bone due to bone marrow hyperplasia, which in turn leads to a narrowing of the internal auditory canal and a progressive compression of the external fibres of the 8th nerve [18]. It should be noted that with this type of slow compression the hearing defect is not neces sarily associated by vestibular involvement.…”

Section: Discussionmentioning

confidence: 99%

Auditory Involvement in Thalassemia Major

S¹,

Argiolu²,

Sanna³

et al. 1979

Acta Haematol

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The auditory function of 75 children affected by homozygous β°-thalassemia, managed with a low transfusion scheme and treated irregularly with low doses of desferrioxamine, and of 75 controls were examined. In 12 patients a mild bilateral conductive hearing impairment due to bony hypertrophy and/or adenoid hypertrophy was found. In 43 cases a moderate monolateral or bilateral sensory-neural hearing loss at high frequencies with recruitment phenomenon was observed. Ferritin levels were determined in a randomly chosen group of these patients with (14) and without hearing loss (11). In the subjects with sensory-neural hearing loss the mean ferritin levels were significantly higher than in those with no hearing defect. There was no obvious relation between sensory-neural damage on the one hand and Hb levels and unit of blood transfused on the other. The results of this study suggest that iron overload could be a cause of damage in the high frequency elements of the auditory mechanism. Intermittent hypoxia and slow 8th nerve compression due to bony hypertrophy as causes of auditory involvement are also discussed.

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Temporal bone histopathology in sickle cell disease

Cited by 61 publications

References 1 publication

Sensorineural hearing loss in sickle cell disease—A prospective study from Oman

Sensorineural hearing loss in sickle cell disease—A prospective study from Oman

Sensorineural hearing loss in Nigerian children with sickle cell disease

Auditory Involvement in Thalassemia Major

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