Temporal and qualitative dynamics of conditioned taste aversions in C57BL/6J and DBA/2J mice self-administering LiCl

Glatt, A. Rebecca; John, Steven J. St.; Lu, Lianyi; Boughter, John D.

doi:10.1016/j.physbeh.2015.10.033

Cited by 8 publications

(15 citation statements)

References 54 publications

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“…Lick efficiency provides a measure of how continuous or discontinuous a mouse’s ingestive behavior is [31]. …”

Section: Methodsmentioning

confidence: 99%

“…With respect to fluid licking and microstructure, mice of the commonly used strain C57BL/6J have been shown in several studies to possess slower lick rates (longer mean interlick intervals) to water or other tastant solutions than DBA/2, 129P3/J, or SWR/J mice [7, 28–31]. Further strain differences have been shown in other microstructural parameters including overall consumption, burst count, burst size and initial licking rate [7, 31, 32].…”

Section: Introductionmentioning

confidence: 99%

“…Further strain differences have been shown in other microstructural parameters including overall consumption, burst count, burst size and initial licking rate [7, 31, 32]. These four strains are included in the current study, along with other classical inbred strains (A/J, AKR/J, BALBcBy/J, C3H/HeJ, CBA/J, FVB/NJ) and the three wild-derived strains mentioned above.…”

Section: Introductionmentioning

confidence: 99%

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Genetic control of oromotor phenotypes: A survey of licking and ingestive behaviors in highly diverse strains of mice

John

Williams

et al. 2017

Physiology & Behavior

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In order to examine genetic influences on fluid ingestion, 20-min intake of either water or 0.1 M sucrose was measured in a lickometer in 18 isogenic strains of mice, including 15 inbred strains and 3 F1 hybrid crosses. Intake and licking data were examined at a number of levels, including lick rate as defined by mean or median interlick interval, as well as several microstructural parameters (i.e. burst-pause structure). In general, strain variation for ingestive phenotypes were correlated across water and sucrose in all strains, indicating fundamental, rather than stimulus-specific, mechanisms of intake. Strain variation was substantial and robust, with heritabilities for phenotypes ranging from 0.22 to 0.73. For mean interlick interval (MPI; a measure of lick rate) strains varied continuously from 94.3 to 127.0 ms, a range consistent with previous studies. Furthermore, variation among strains for microstructural traits such as burst size and number suggested that strains possess different overall ingestive strategies, with some favoring more short bursts, and others favoring fewer, long bursts. Strains also varied in cumulative intake functions, exhibiting both linear and decelerated rates of intake across the session.

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“…Lick efficiency provides a measure of how continuous or discontinuous a mouse’s ingestive behavior is [31]. …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Genetic control of oromotor phenotypes: A survey of licking and ingestive behaviors in highly diverse strains of mice

John

Williams

et al. 2017

Physiology & Behavior

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“…It includes a plain text file describing its use, as well as several pointers on the use of Audacity to generate the required data files. Parameters for describing licking microstructure were adapted from previous literature [ 8 , 9 ]. Presently the script accommodates two-channel recordings.…”

Section: Design Files Summarymentioning

confidence: 99%

An open-source lickometer and microstructure analysis program

2018

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Described herein is a design for a user-constructed electronic lickometer, intended to allow users to conduct relatively simple behavioral experiments with rodents while avoiding several common stumbling blocks. Primarily, this system does not require the purchase of specialized scientific equipment or software. Additionally, it is possible for users to construct and operate this lickometer without the prerequisite of advanced knowledge of electronics or programming. Overall, the goal of this apparatus is to provide a simple and affordable alternative for users seeking to study ingestion behaviors in rodents, while still allowing the user to obtain high-resolution data and conduct sophisticated microstructural analysis of the behavior in question. All of this is achieved using low-cost and commonly available materials for the construction of the apparatus itself, and open-source software to collect and analyze data. The only substantial prerequisites for this design are a PC with a 3.5 mm microphone input and a comfortable understanding of power tools. Finally, a validation of the operation of the describe apparatus is included.

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“…The increase in meal duration coupled with a decrease in licks per meal reflects a slower lick rate with more frequent and lengthy pauses during the meal and fewer licks per burst. This slower pattern of consumption is associated with negative postingestive influences such as gastric distress [ 28 – 30 ]. Dextran, a polymer bulking agent in the FDT, has been reported to interact with casein proteins in milk through electrostatic interaction, causing aggregation leading to destabilization of milk.…”

Section: Discussionmentioning

confidence: 99%

The Palatability of Lopinavir and Ritonavir Delivered by an Innovative Freeze-Dried Fast-Dissolving Tablet Formulation

Pittman

Brantly

Drobonick

et al. 2018

AIDS Research and Treatment

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Negative hedonic sensory qualities of HIV antiretroviral drugs often reduce patient adherence particularly in pediatric populations requiring oral consumption. This study examines the palatability of an innovative delivery mechanism utilizing a freeze-drying-in-blister approach to create fast-dissolving tablets (FDTs) containing a fixed-dose combination of lopinavir and ritonavir (LPV/r). Consumption patterns of solutions during brief-access and long-term testing and baby foodstuff consumption were analyzed to evaluate the orosensory detection and avoidance of placebo FDTs containing no LPV/r (FDT−) and FDTs containing LPV/r (FDT+). Rats showed no change in consumption patterns for the placebo FDT− compared with control solutions. Rats can detect but do not avoid FDT+ at body-weight-adjusted dosages in both brief-access (30-s) and long-term (23 h) consumption tests. There is an aversive response to concentrated doses of FDT+ during brief-access tests that cannot be masked by 25% sucrose. However, the strongest FDT+ concentration was not rejected when mixed with 50 g of applesauce, banana sauce, or rice cereal baby foodstuffs. The averseness of the FDT+ was associated with the presence of LPV/r and not the FDT− formulation itself. The novel FDT formulation appears to be a palatable delivery mechanism for oral antiretroviral pharmaceuticals especially when mixed with baby foodstuffs.

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Temporal and qualitative dynamics of conditioned taste aversions in C57BL/6J and DBA/2J mice self-administering LiCl

Cited by 8 publications

References 54 publications

Genetic control of oromotor phenotypes: A survey of licking and ingestive behaviors in highly diverse strains of mice

Genetic control of oromotor phenotypes: A survey of licking and ingestive behaviors in highly diverse strains of mice

An open-source lickometer and microstructure analysis program

The Palatability of Lopinavir and Ritonavir Delivered by an Innovative Freeze-Dried Fast-Dissolving Tablet Formulation

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