Genetic control of oromotor phenotypes: A survey of licking and ingestive behaviors in highly diverse strains of mice

Abstract

In order to examine genetic influences on fluid ingestion, 20-min intake of either water or 0.1 M sucrose was measured in a lickometer in 18 isogenic strains of mice, including 15 inbred strains and 3 F1 hybrid crosses. Intake and licking data were examined at a number of levels, including lick rate as defined by mean or median interlick interval, as well as several microstructural parameters (i.e. burst-pause structure). In general, strain variation for ingestive phenotypes were correlated across water and sucrose in all strains, indicating fundamental, rather than stimulus-specific, mechanisms of intake. Strain variation was substantial and robust, with heritabilities for phenotypes ranging from 0.22 to 0.73. For mean interlick interval (MPI; a measure of lick rate) strains varied continuously from 94.3 to 127.0 ms, a range consistent with previous studies. Furthermore, variation among strains for microstructural traits such as burst size and number suggested that strains possess different overall ingestive strategies, with some favoring more short bursts, and others favoring fewer, long bursts. Strains also varied in cumulative intake functions, exhibiting both linear and decelerated rates of intake across the session.

Microstructural changes in human ingestive behavior after Roux-en-Y gastric bypass during liquid meals

“…An applied implication of our findings is related to the highly precise description of the postbariatric ingestive phenotype ( 51 ), which may provide a readily available reference for future weight loss therapies. In fact, a typical post-RYGB eating style may be characterized in future studies, including male participants and measurements of solid food intake.…”

Taste Impairments in a Parkinson’s Disease Model Featuring Intranasal Rotenone Administration in Mice

“…Although there were no significant correlations between the weight loss and TH-ir-Nos loss in the SN (Supplementary Figure 1), the weight loss may been accepted [26]. It is also considered that the total 643 number of licks reflects taste preferences more than 644 the ILI [44]. In this study, after the rotenone adminis-645 tration, the total number of licks, but not the ILI, was 646 significantly increased in the 1w-Rot group (Fig.…”

Challenges in the interpretation and therapeutic manipulation of human ingestive microstructure

“…This ingestive pattern preceded weight-loss, it manifested in all patients (unpublished data), and may be explained in part by an effect of RYGB in increasing the postingestive caloric sensibility (40,54). Although these observations need to be confirmed in future studies using solid food stimuli and larger cohorts, they already provide an ingestive phenotype (68), which may be used as a reference when cognitive interventions targeting obesity are designed.…”