Temporal and long‐term gut microbiota variation in allergic disease: A prospective study from infancy to school age

Sjödin, Kotryna Simonyté; Hammarström, Marie‐Louise; Rydén, Patrik; Sjödin, Andreas; Hernell, Olle; Engstrand, Lars; West, Christina

doi:10.1111/all.13485

Cited by 77 publications

(66 citation statements)

References 43 publications

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“…Prevotella is difficult to culture, being a strict anaerobe, and its carriage was not reported. However, a recent longitudinal analysis of 63 Swiss children found, using culture-independent techniques, underrepresentation of the genus Prevotella in fecal samples collected at 6 months, 13 months and 8 years from participants with IgE related allergic disease 22 . Consistent with this, a study of 83 South African children found a cross-sectional association between low relative abundance of P. copri and atopic dermatitis 23 .…”

Section: Discussionmentioning

confidence: 99%

Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring

et al. 2020

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Institute*, the BIS Investigator Group* In mice, the maternal microbiome influences fetal immune development and postnatal allergic outcomes. Westernized populations have high rates of allergic disease and low rates of gastrointestinal carriage of Prevotella, a commensal bacterial genus that produces short chain fatty acids and endotoxins, each of which may promote the development of fetal immune tolerance. In this study, we use a prebirth cohort (n = 1064 mothers) to conduct a nested case-cohort study comparing 58 mothers of babies with clinically proven food IgE mediated food allergy with 258 randomly selected mothers. Analysis of the V4 region of the 16S rRNA gene in fecal samples shows maternal carriage of Prevotella copri during pregnancy strongly predicts the absence of food allergy in the offspring. This association was confirmed using targeted qPCR and was independent of infant carriage of P. copri. Larger household size, which is a well-established protective factor for allergic disease, strongly predicts maternal carriage of P. copri.

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Section: Discussionmentioning

confidence: 99%

Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring

et al. 2020

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“…[1][2][3] Animal studies have provided compelling evidence to support a causal role of the intestinal microbiota and its metabolites, especially in early life, in the etiology of allergic diseases. [3][4][5][6] Numerous epidemiological studies [7][8][9][10][11][12] also suggest that the infant intestinal microbiota plays an important role in the manifestation of allergic diseases and asthma, although actual results vary considerably between studies. Approximately half of the studies that examined intestinal microbial diversity in infancy and childhood reported a lower diversity among children with (subsequent) allergies, whereas the remaining studies found no evidence for such an association.…”

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confidence: 99%

Development of the Microbiota and Associations With Birth Mode, Diet, and Atopic Disorders in a Longitudinal Analysis of Stool Samples, Collected From Infancy Through Early Childhood

et al. 2020

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“…An increased microbial diversity along with the relative abundance of certain bacteria, such as Lactobacillus spp. (63), has been correlated with a lower risk of IgE-associated allergic diseases, namely atopic dermatitis and wheezing, through a decreasing Th2-mediated response (64). No significant association between the diversity of complementary foods and allergic rhinitis has been found so far (65).…”

Section: Early Lifementioning

confidence: 99%

Current Insights on Early Life Nutrition and Prevention of Allergy

et al. 2020

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The incidence of allergic diseases in childhood appears to have significantly increased over the last decades. Since environmental factors, including diet, have been thought to play a significant role in the development of these diseases, there is great interest in identifying prevention strategies related to early nutritional interventions. Breastfeeding is critical for the immune development of newborns and infants through immune-modulating properties and it impacts the establishment of a healthy gut microbiota. However, the evidence for a protective role of breastfeeding against the development of food allergy in childhood is controversial, and there is little evidence to support the benefits of an antigen avoidance diet during lactation. Although it is not possible to draw a definitive conclusion about the protective role of breast milk against allergic diseases, exclusive breastfeeding is still recommended throughout the first 6 months of life due to associated health benefits. Furthermore, recommendations regarding complementary feeding in infancy have been significantly modified over the last few decades. Several studies have shown that delayed exposure to allergenic foods does not have a role in allergy prevention and recent guidelines recommend against delaying the introduction of complementary foods after 6 months of age, both in high-and low-risk infants. However, trials investigating this dietary approach have reported equivocal results so far. This review summarizes the available high-quality evidence regarding the efficacy of the principal dietary interventions proposed in early life to prevent allergic diseases in children.

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Temporal and long‐term gut microbiota variation in allergic disease: A prospective study from infancy to school age

Cited by 77 publications

References 43 publications

Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring

Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring

Development of the Microbiota and Associations With Birth Mode, Diet, and Atopic Disorders in a Longitudinal Analysis of Stool Samples, Collected From Infancy Through Early Childhood

Current Insights on Early Life Nutrition and Prevention of Allergy

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