Development of the Microbiota and Associations With Birth Mode, Diet, and Atopic Disorders in a Longitudinal Analysis of Stool Samples, Collected From Infancy Through Early Childhood

Galazzo, Gianluca; Best, Niels van; Bervoets, Liene; Dapaah, Isaac Oteng; Savelkoul, Paul H. M.; Hornef, Mathias W.; Hutton, Eileen K.; Morrison, Katherine M.; Holloway, Alison C.; McDonald, Helen; Ratcliffe, Elyanne M.; Stearns, Jennifer C.; Schertzer, Jonathan D.; Surette, Mike G.; Thabane, Lehana; Mommers, Monique; Lau, Susanne; Hamelmann, Eckard; Penders, John

doi:10.1053/j.gastro.2020.01.024

Cited by 175 publications

(171 citation statements)

References 57 publications

Supporting

Mentioning

161

Contrasting

Unclassified

Order By: Relevance

“…These findings have not only been related to presence of bacteria but also to the microbial metabolites such as SCFA (137) or components such as commensal DNA containing CpG (unmethylated cytosine phosphate guanosine dinucleotides) motifs (138) and polysaccharide A (PSA) (139). The development of a symbiotic relationship during early years may determine the development of several diseases (140).…”

Section: The Intestinal Microbiota In Metabolic Diseasesmentioning

confidence: 99%

Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes

et al. 2020

View full text Add to dashboard Cite

The gut microbiota has been linked to the development of obesity and type 2 diabetes (T2D). The underlying mechanisms as to how intestinal microbiota may contribute to T2D are only partly understood. It becomes progressively clear that T2D is characterized by a chronic state of low-grade inflammation, which has been linked to the development of insulin resistance. Here, we review the current evidence that intestinal microbiota, and the metabolites they produce, could drive the development of insulin resistance in obesity and T2D, possibly by initiating an inflammatory response. First, we will summarize major findings about immunological and gut microbial changes in these metabolic diseases. Next, we will give a detailed view on how gut microbial changes have been implicated in low-grade inflammation. Lastly, we will critically discuss clinical studies that focus on the interaction between gut microbiota and the immune system in metabolic disease. Overall, there is strong evidence that the tripartite interaction between gut microbiota, host immune system and metabolism is a critical partaker in the pathophysiology of obesity and T2D.

show abstract

Section: The Intestinal Microbiota In Metabolic Diseasesmentioning

confidence: 99%

Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Following birth, establishment of the early intestinal microbiota is characterized by major fluctuations in the relative abundance of the prominent bacterial taxa associated with an increase in the bacterial diversity over time. 1 , 2 …”

Section: Introductionmentioning

confidence: 99%

Influence of probiotic supplementation on the developing microbiota in human preterm neonates

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background Oral administration of probiotic bacteria to preterm neonates has been recommended to prevent the development of necrotizing enterocolitis (NEC). The influence of probiotics on the endogenous microbiome, however, has remained incompletely understood. Study design & methods Here, we performed an observational study including 80 preterm neonates born at a gestational age <32-weeks to characterize the persistence of probiotic bacteria after no treatment or oral administration of two different probiotic formula and their influence on the microbial ecosystem during and after the intervention and their association with the development of NEC. Weekly fecal samples were profiled by 16S rRNA sequencing and monitored for the presence of the probiotic bacteria by quantitative PCR. Results Microbiota profiles differed significantly between the control group and both probiotic groups. Probiotic supplementation was associated with lower temporal variation as well as higher relative abundance of Bifidobacterium and Enterobacter combined with reduced abundance of Escherichia, Enterococcus , and Klebsiella . Colonization by probiotic bifidobacteria was observed in approximately 50% of infants although it remained transient in the majority of cases. A significantly reduced monthly incidence of NEC was observed in neonates supplemented with probiotics. Conclusion Our results demonstrate successful transient colonization by probiotic bacteria and a significant influence on the endogenous microbiota with a reduced abundance of bacterial taxa associated with the development of NEC. These results emphasize that probiotic supplementation may allow targeted manipulation of the enteric microbiota and confer a clinical benefit. (Clinical Trial Registry accession number: DRKS/GCTR 00021034)

show abstract

“…Interestingly, skin colonization with S. aureus is also correlated with the onset of food allergy (peanut and egg) in infants, independently of the severity of atopic dermatitis ( 130 , 131 ). Furthermore, as breast feeding is negatively associated with risk of food allergy it is of interest that cessation of this feeding has recently been found to diminish the abundance of Staphylococcus species in the infant fecal microbiome ( 132 ). Despite these findings there is currently very little evidence for a direct role of specific bacterial proteins, including Staphylococcal enterotoxins, in IgE-mediated food allergy.…”

Section: Interplay Between Iecs and The Microbiome In Food Allergymentioning

confidence: 99%

Role of the Intestinal Epithelium and Its Interaction With the Microbiota in Food Allergy

2020

View full text Add to dashboard Cite

The intestinal epithelial tract forms a dynamic lining of the digestive system consisting of a range of epithelial cell sub-types with diverse functions fulfilling specific niches. The intestinal epithelium is more than just a physical barrier regulating nutrient uptake, rather it plays a critical role in homeostasis through its intrinsic innate immune function, pivotal regulation of antigen sensitization, and a bi-directional interplay with the microbiota that evolves with age. In this review we will discuss these functions of the epithelium in the context of food allergy.

show abstract

Development of the Microbiota and Associations With Birth Mode, Diet, and Atopic Disorders in a Longitudinal Analysis of Stool Samples, Collected From Infancy Through Early Childhood

Abstract: In a longitudinal study of fecal microbiota of children from 5 weeks through 6 to 11 years, we tracked changes in diversity and composition associated with the development of allergies and asthma.

Cited by 175 publications

References 57 publications

Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes

Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes

Influence of probiotic supplementation on the developing microbiota in human preterm neonates

Role of the Intestinal Epithelium and Its Interaction With the Microbiota in Food Allergy

Contact Info

Product

Resources

About