Role of the Intestinal Epithelium and Its Interaction With the Microbiota in Food Allergy

Ali, Ayesha; Tan, HuiYing; Kaiko, Gerard E.

doi:10.3389/fimmu.2020.604054

Cited by 76 publications

(73 citation statements)

References 138 publications

(180 reference statements)

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“…As mentioned above, alterations in the integrity of the epithelial barrier are associated with a wide range of gastrointestinal and non-gastrointestinal disorders [5][6][7][8][9][10][11][12]. The passage of pro-inflammatory molecules and harmful pathogenic microorganisms through the impaired intestinal barrier induces the activation of the immune system, which can lead to the appearance of processes associated with chronic inflammation [36].…”

Section: The Intestinal Epithelium: At the Interface Of Gut Microbiota And Mucosal Immunitymentioning

confidence: 99%

“…When the function of the intestinal barrier is compromised, potentially harmful microbes are able to pass through (i.e., leaky gut) [4]. In this context, Microorganisms 2021, 9, 1634 2 of 21 there is great interest in identifying the factors and conditions that influence intestinal barrier function, as they may have a profound impact on several intestinal disorders, including inflammatory bowel diseases (IBD) [5], irritable bowel syndrome (IBS) [6], and colorectal cancer [7], as well as on other non-gastrointestinal pathologies, such as obesity [8], diabetes [9], neurological disorders [10], and food allergies (FA) [11,12].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bioactive Compounds in Food as a Current Therapeutic Approach to Maintain a Healthy Intestinal Epithelium

et al. 2021

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The intestinal epithelium serves as an effective barrier against the external environment, hampering the passage of potentially harmful substances (such as pathogenic microbes) that could trigger an exacerbated host immune response. The integrity of this barrier is thus essential for the maintenance of proper intestinal homeostasis and efficient protective reactions against chemical and microbial challenges. The principal consequence of intestinal barrier defects is an increase in intestinal permeability, which leads to an increased influx of luminal stressors, such as pathogens, toxins, and allergens, which in turn trigger inflammation and immune response. The fine and fragile balance of intestinal homeostasis can be altered by multiple factors that regulate barrier function, many of which are poorly understood. This review will address the role of gut microbiota as well as food supplements (such as probiotics, prebiotics, and synbiotics) in modulating gut health and regulating intestinal barrier function. In particular, we will focus on three human pathologies: inflammatory bowel disease, irritable bowel syndrome, and food allergy.

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Section: The Intestinal Epithelium: At the Interface Of Gut Microbiota And Mucosal Immunitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioactive Compounds in Food as a Current Therapeutic Approach to Maintain a Healthy Intestinal Epithelium

et al. 2021

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“…As it has been described before, there are a plethora of agents that affect the microbiome, regulating disease progression. Importantly, different cells from the intestine, such as enterocytes, intestinal epithelial cells, colonocytes, and many others, which are involved in the maintenance of the intestinal barrier, are able to generate exosomes [ 90 , 91 ]. For a better understanding of this topic, a recent review has been published analyzing the effect of different EVs produced by different tissues throughout the body involved in the control of pancreatic beta-cell function [ 16 ].…”

Section: Gut Microbiota Shapes Pancreatic Beta-cellsmentioning

confidence: 99%

Multi-Organ Crosstalk with Endocrine Pancreas: A Focus on How Gut Microbiota Shapes Pancreatic Beta-Cells

Fernández-Millán

Guillén

2022

Biomolecules

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Type 2 diabetes (T2D) results from impaired beta-cell function and insufficient beta-cell mass compensation in the setting of insulin resistance. Current therapeutic strategies focus their efforts on promoting the maintenance of functional beta-cell mass to ensure appropriate glycemic control. Thus, understanding how beta-cells communicate with metabolic and non-metabolic tissues provides a novel area for investigation and implicates the importance of inter-organ communication in the pathology of metabolic diseases such as T2D. In this review, we provide an overview of secreted factors from diverse organs and tissues that have been shown to impact beta-cell biology. Specifically, we discuss experimental and clinical evidence in support for a role of gut to beta-cell crosstalk, paying particular attention to bacteria-derived factors including short-chain fatty acids, lipopolysaccharide, and factors contained within extracellular vesicles that influence the function and/or the survival of beta cells under normal or diabetogenic conditions.

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“…Skin colonization with Staphylococcus aureus in patients with atopic dermatitis has been associated with an increased risk of food allergy [ 78 ]. Likewise, a loss of balance and diversity in the intestinal microbiome increases food allergy risk [ 21 ].…”

Section: Allergy and Functional Abdominal Pain Disordersmentioning

confidence: 99%

“…Non-absorbed sugars and fructooligosaccharides alter the intestinal microbiome and production of short-chain fatty acids, both of which affect the development of food allergies [ 6 , 13 , 14 , 17 , 18 , 19 , 20 ]. The altered microbiome can interrupt the intestinal epithelial barrier (another factor highly implicated in FAPDs) with a subsequent increase in the immune system’s exposure to luminal food and microbial antigens [ 21 ]. Lastly, it is recognized that dietary compounds (or metabolic byproducts) can modulate mast cell function [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Update on the Role of Allergy in Pediatric Functional Abdominal Pain Disorders: A Clinical Perspective

2021

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Both functional abdominal pain disorders (FAPDs) and food allergies are relatively common in children and adolescents, and most studies report an association between FAPDs and allergic conditions. FAPDs share pathophysiologic processes with allergies, including both immune and psychological processes interacting with the microbiome. No conclusive data are implicating IgE-mediated reactions to foods in FAPDs; however, there may be patients who have IgE reactions localized to the gastrointestinal mucosa without systemic symptoms that are not identified by common tests. In FAPDs, the data appears stronger for aeroallergens than for foods. It also remains possible that food antigens initiate an IgG reaction that promotes mast cell activation. If a food allergen is identified, the management involves eliminating the specific food from the diet. In the absence of systemic allergic symptoms or oral allergy syndrome, it appears unlikely that allergic triggers for FAPDs can be reliably identified by standard testing. Medications used to blunt allergic reactions or symptomatically treat allergic reactions may be useful in FAPDs. The purpose of the current manuscript is to review the current literature regarding the role of allergy in FAPDs from a clinical perspective, including how allergy may fit in the current model of FAPDs.

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Role of the Intestinal Epithelium and Its Interaction With the Microbiota in Food Allergy

Cited by 76 publications

References 138 publications

Bioactive Compounds in Food as a Current Therapeutic Approach to Maintain a Healthy Intestinal Epithelium

Bioactive Compounds in Food as a Current Therapeutic Approach to Maintain a Healthy Intestinal Epithelium

Multi-Organ Crosstalk with Endocrine Pancreas: A Focus on How Gut Microbiota Shapes Pancreatic Beta-Cells

Update on the Role of Allergy in Pediatric Functional Abdominal Pain Disorders: A Clinical Perspective

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