Template‐Directed Nucleation and Growth of Inorganic Nanoparticles on DNA Scaffolds

Stearns, Linda A.; Chhabra, Rajendra S.; Sharma, Jaswinder; Liu, Yan; Petuskey, William T.; Chaput, John C.

doi:10.1002/anie.200903319

Cited by 70 publications

(44 citation statements)

References 25 publications

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“…[2,5] 0 wird dann auf der dsDNA gebündelt und bildet so stabile Nanopartikel. Wir fanden auch, dass DNA-Dreifachstränge die Nanopartikelbildung nicht fördern (Abbildung S6).…”

Section: Methodsunclassified

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Selektive dsDNA‐gesteuerte Bildung von Kupfer‐Nanopartikeln in Lösung

et al. 2010

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Wählerische Partikel: Eine Methode für die selektive Bildung von Kupfer‐Nanopartikeln an dsDNA‐Templaten wurde entwickelt. Die Größe der Nanopartikel kann über die Länge der dsDNA gesteuert werden, und einzelsträngige DNA wirkt nicht als Templat (siehe Schema). Einzelstrangüberhänge wurden genutzt, um eine Nanostruktur bestehend aus zwei metallisierten dsDNAs und einem nichtmetallisierten starren Linker aufzubauen.

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“…[2,5] 0 wird dann auf der dsDNA gebündelt und bildet so stabile Nanopartikel. Wir fanden auch, dass DNA-Dreifachstränge die Nanopartikelbildung nicht fördern (Abbildung S6).…”

Section: Methodsunclassified

“…So wurde etwa eine Vielzahl von Verfahren für die Beschichtung von DNA mit Au 0 , Pd 0 , Pt 0 , Ag 0 , Cu 0 und CdS beschrieben. [2,3] Allerdings ist erst wenig über die kontrollierte Modifizierung von ausgewählten Bereichen der DNA bekannt. Das erste Beispiel für die selektive Metallbeschichtung einer DNA wurde von Braun und Mitarbeitern vorgestellt.…”

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Selektive dsDNA‐gesteuerte Bildung von Kupfer‐Nanopartikeln in Lösung

et al. 2010

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“…3,4,7,9,10 For example, DNA has been used to construct scaffolds with well-defined geometry and periodicity, upon which DNA-functionalized nanoparticles were immobilized to follow the underlying DNA pattern. 4,8,[11][12][13] In another approach, linker DNAs are used to assemble inorganic nanoparticle oligomers and polymers. 1,2 Gold nanoparticles (AuNPs) are particularly attractive for these studies as DNA conjugation to Au surface can be achieved using simple Au-thiol chemistry.…”

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confidence: 99%

Programmable Assembly of DNA-Functionalized Liposomes by DNA

Dave

Liu

2011

ACS Nano

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Bionanotechnology involves the use of biomolecules to control both the structure and property of nanomaterials. One of the most studied examples is DNA-directed assembly of inorganic nanoparticles such as gold nanoparticles (AuNPs). However, systematic studies on DNAlinked soft nanoparticles, such as liposomes, are still lacking. We herein report the programmable assembly and systematic characterization of DNA-linked liposomes as a function of liposome size, charge, fluidity, composition, DNA spacer, linker DNA sequence, and salt concentration for direct comparison to DNA-directed assembly of AuNPs. Similar to the assemblies of AuNPs, sharp melting transitions were observed for liposomes where the first derivative of the melting curve full width at half-maximum (fwhm) is equal to or less than 1 °C for all of the tested liposomes, allowing sequence specific DNA detection. We found that parameters such as liposome size, charge, and fluidity have little effect on the DNA melting temperature. Cryo-TEM studies showed that programmable assemblies can be obtained and that the majority of the liposomes maintained a spherical shape in the assembled state. While liposome and AuNP systems are similar in many aspects, there are also important differences that can be explained by their respective physical properties. KEYWORDS: liposomes

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“…The DNA origami nanotube composed of six DNA helices bundled with a hexagonal cross section was designed and synthesized in a similar fashion as described previously 25-26 . The fully extended, end-to-end length of the DNA origami nanotube is ~380 nm.…”

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confidence: 99%

Interconnecting Gold Islands with DNA Origami Nanotubes

Ding¹,

Wu²,

Xu³

et al. 2010

Nano Lett.

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116

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Scaffolded DNA origami has recently emerged as a versatile, programmable method to fold DNA into arbitrarily shaped nanostructures that are spatially addressable, with sub-10 nm resolution. Toward functional DNA nanotechnology, one of the key challenges is to integrate the bottom up self-assembly of DNA origami with the top-down lithographic methods used to generate surface patterning. In this report we demonstrate that fixed length DNA origami nanotubes, modified with multiple thiol groups near both ends, can be used to connect surface patterned gold islands (tens of nanometers in diameter) fabricated by electron beam lithography (EBL). Atomic force microscopic imaging verified that the DNA origami nanotubes can be efficiently aligned between gold islands with various inter-island distances and relative locations. This development represents progress toward the goal of bridging bottom up and top down assembly approaches.

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Template‐Directed Nucleation and Growth of Inorganic Nanoparticles on DNA Scaffolds

Cited by 70 publications

References 25 publications

Selektive dsDNA‐gesteuerte Bildung von Kupfer‐Nanopartikeln in Lösung

Selektive dsDNA‐gesteuerte Bildung von Kupfer‐Nanopartikeln in Lösung

Programmable Assembly of DNA-Functionalized Liposomes by DNA

Interconnecting Gold Islands with DNA Origami Nanotubes

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