Template bleeding time after ingestion of ultra low dosages of acetyl salicylic acid in healthy subjects. Preliminary study

Doutremepuich, C.; Pailley, D.; Anne, M.C.; Sèze, O. De; Paccalin, J; Quilichini, R

doi:10.1016/0049-3848(87)90406-3

Cited by 14 publications

(6 citation statements)

References 5 publications

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“…The results obtained in this study are in harmony with those previously observed with aspirin used at very ultra low dosage [2]: bleeding time is statistically reduced af ter ingestion of this drug at such dosage. This phenomenon is quite new and for this reason the present study was performed in a con trolled trial with very rigorous conditions.…”

Section: Discussionsupporting

confidence: 80%

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Aspirin at Very Ultra Low Dosage in Healthy Volunteers: Effects on Bleeding Time, Platelet Aggregation and Coagulation

Doutremépuich

Sèze²,

Roy³

et al. 1990

Pathophysiol Haemos Thromb

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Aspirin at very ultra low dosage was tested in healthy volunteers (n = 20) in a randomized, double-blind and placebo-controlled trial. The results showed a bleeding time reduction (p < 0.05) in volunteers having previously ingested aspirin. Platelet aggregation on platelet-rich plasma was not statistically modified after aspirin ingestion. Thrombin clotting time was always higher (p < 0.05) in the treated group.

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Section: Discussionsupporting

confidence: 80%

“…This previous observa tion [2,3] made on healthy volunteers was quite new. No simple explanation could be given and it seemed that only one test was not sufficient to reflect the mechanism of action of aspirin at very ultra low dosage.…”

Section: Introductionmentioning

confidence: 92%

Aspirin at Very Ultra Low Dosage in Healthy Volunteers: Effects on Bleeding Time, Platelet Aggregation and Coagulation

Doutremépuich

Sèze²,

Roy³

et al. 1990

Pathophysiol Haemos Thromb

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“…The first experimental model showed paradoxical or secondary thromboembolism after the administration of substantial [6][7][8][9][10][11][12][13][14][15] or ultra low 16,17 doses of antithrombotic agents (rebound effect). The second model showed the effect of substantial 18 or ultra low [19][20][21][22][23] doses of aspirin in prophylaxis or reduction of hemorrhagic risks (reducing the bleeding time or the antithrombotic effect), neutralising the side effect of aspirin previously administration in high doses (identity principle or curative rebound effect).…”

Section: Discussionmentioning

confidence: 99%

“…Experimental studies, in vitro and in vivo, show that after the interruption or discontinuation of ASA or other drugs for prophylaxis of thromboembolism, the organism reacts by a secondary action or vital reaction that stimulates the COX-1 production and the blood platelet activity to values much higher than baseline, increasing the development of thrombus and the probability of a embolic event [acute myocardial infarction (AMI), cerebral vascular accident (CVA), etc] in susceptible individuals, both in substantial, [6][7][8][9][10][11][12][13][14][15] and infinitesimal doses. 16,17 Other experiments showed the effect of substantial 18 or ultra low [19][20][21][22][23] doses of aspirin in prophylaxis or reduction of haemorrhagic risks (reducing the bleeding time or the anti-thrombotic effect), neutralising the side effect of previously administered aspirin.…”

Section: Similitude and Aspirinmentioning

confidence: 99%

Evidence of the principle of similitude in modern fatal iatrogenic events

Teixeira

2006

Homeopathy

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Samuel Hahnemann attributed fundamental importance to the principle of similitude, promoting it to a 'natural law'. Observing that enantiopathic or allopathic treatment produced enduring aggravation of the disease symptoms after a brief and transitory initial relief, he systematised homeopathic treatment, prescribing substances that provoke similar symptoms in healthy individual. Based on clinical and experimental observations, he anticipated the concept of homeostasis, dividing the effects of substances into: primary action of the medicine followed by secondary action or reaction of the organism. This reaction, known as the rebound effect or paradoxical action by modern pharmacology, used to awake the curative response of the body when the principle of similitude is applied, is responsible for several iatrogenic diseases when used on the basis of the principle of contraries. This study discusses the role of this paradoxical reaction of the organism in the fatal side effects of four important drugs, used according to the model of enantiopathic treatment of the symptoms. I present evidence relating to acetylsalicylic acid, rofecoxib, antidepressants and long-acting bronchodilators. The consequences of the allopathic treatment could be decreased if health professionals valued homeostasis, minimising the rebound effect of the organism by gradual suspension of palliative drugs.

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“…Moreover, this effect of aspirin was not modified by papain, a proteolytic enzyme. [2][3][4][5][6][7]…”

Section: Effect Of Aspirin On Plateletsmentioning

confidence: 99%

Effects of Ultra-Low-Dose Aspirin in Thrombosis and Haemorrhage

Eizayaga

Belon²,

Desplat

et al. 2019

Homeopathy

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Background Aspirin is the oldest and possibly the most widely used pharmacologically active substance still used in allopathic medicine. Its effect on fever and inflammation has paved the way to its anti-thrombotic effect. Dilutions of aspirin have been tested for many years in the University of Bordeaux, in humans as well as in animal models. Methods This article is a review of the totality of articles published by the Laboratory of Hematology of the Faculty of Pharmacy of the University of Bordeaux, reporting different doses and dilutions of aspirin, different kinds of inhibitors, transgenic mice and animal models of disease such as portal hypertension and cirrhosis. Results Homeopathic dilutions of aspirin, notably 15 cH, have shown a pro-thrombotic effect in humans and in in-vivo animal studies. Longitudinal studies in rats have also shown an initial anti-thrombotic effect followed by a pro-thrombotic effect of aspirin several days after a single high-dose administration. This pro-thrombotic effect seems to act by inhibiting the cyclooxygenase (COX)-2 pathway in studies performed with COX selective inhibitors and in knock-out mice without COX-1 or COX-2. This effect may explain the thrombo-embolic complications described after aspirin withdrawal for the purposes of surgery or after non-compliance with anti-platelet therapy, and it may be beneficial in normalising primary haemostasis and decreasing haemorrhage in animal models of portal hypertension and cirrhosis. Conclusions Aspirin 15 cH acts through the inhibition of the COX-2 pathway producing a clear pro-thrombotic effect. Further studies should clarify if the pro-thrombotic effect of aspirin withdrawal and the effect of aspirin 15 cH are related, as secondary effects of the same drug. Clarifying this last outcome may be of great significance to public health.

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Template bleeding time after ingestion of ultra low dosages of acetyl salicylic acid in healthy subjects. Preliminary study

Cited by 14 publications

References 5 publications

Aspirin at Very Ultra Low Dosage in Healthy Volunteers: Effects on Bleeding Time, Platelet Aggregation and Coagulation

Aspirin at Very Ultra Low Dosage in Healthy Volunteers: Effects on Bleeding Time, Platelet Aggregation and Coagulation

Evidence of the principle of similitude in modern fatal iatrogenic events

Effects of Ultra-Low-Dose Aspirin in Thrombosis and Haemorrhage

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