Temperature-triggered tumor-specific delivery of anticancer agents by cRGD-conjugated thermosensitive liposomes

Kim, Min Sang; Lee, Don-Wook; Park, Kitae; Park, Sangjun; Choi, Eun‐Jung; Park, Eun Sung; Kim, Hyun Ryoung

doi:10.1016/j.colsurfb.2013.12.045

Cited by 68 publications

(50 citation statements)

References 25 publications

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“…HT also increases vascular blood flow and permeability as well as tumor oxygenation [19][20][21]. In recent years, a few studies investigated the strategy of ligand medicated targeted thermosensitive liposomes (TSL) in order to improve drug delivery to tumors [22][23][24]. However, there is currently no research available on EGFR targeted TSL.…”

Section: Introductionmentioning

confidence: 99%

EGFR targeted thermosensitive liposomes: A novel multifunctional platform for simultaneous tumor targeted and stimulus responsive drug delivery

Haeri

Zalba

Hagen

et al. 2016

Colloids and Surfaces B: Biointerfaces

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Section: Introductionmentioning

confidence: 99%

EGFR targeted thermosensitive liposomes: A novel multifunctional platform for simultaneous tumor targeted and stimulus responsive drug delivery

Haeri

Zalba

Hagen

et al. 2016

Colloids and Surfaces B: Biointerfaces

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“…We set out to design and generate a targeted hydrogel photothermal nanotherapy platform that would release therapeutic cargo to tumors after NIR laser-triggered heating by incorporating heat sensitive-based liposome (HSL) (22) formulations into targeted phage-based hydrogel networks (Fig. S1).…”

Section: Resultsmentioning

confidence: 99%

Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release

Hosoya

Dobroff²,

Driessen

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

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A major challenge of targeted molecular imaging and drug delivery in cancer is establishing a functional combination of ligand-directed cargo with a triggered release system. Here we develop a hydrogelbased nanotechnology platform that integrates tumor targeting, photon-to-heat conversion, and triggered drug delivery within a single nanostructure to enable multimodal imaging and controlled release of therapeutic cargo. In proof-of-concept experiments, we show a broad range of ligand peptide-based applications with phage particles, heat-sensitive liposomes, or mesoporous silica nanoparticles that self-assemble into a hydrogel for tumor-targeted drug delivery. Because nanoparticles pack densely within the nanocarrier, their surface plasmon resonance shifts to near-infrared, thereby enabling a laser-mediated photothermal mechanism of cargo release. We demonstrate both noninvasive imaging and targeted drug delivery in preclinical mouse models of breast and prostate cancer. Finally, we applied mathematical modeling to predict and confirm tumor targeting and drug delivery. These results are meaningful steps toward the design and initial translation of an enabling nanotechnology platform with potential for broad clinical applications. A long-term goal in contemporary cancer nanomedicine has been to design and generate drug delivery systems that improve the narrow therapeutic window associated with conventional chemotherapeutics (1, 2). Conceptually, several nanotechnologybased entity candidates, including protocells (3), biosynthetic nanoparticles (NPs), viruses, and liposome-based nanoparticles, could be targeted for active delivery through a defined cell surface ligand receptor system and/or physically triggered for finely tuned cargo release (2, 4, 5).Numerous efforts have been made to functionalize NPs by combining them with antibodies, aptamers, peptides, vitamins, or carbohydrates (6-8), but the majority of studies involve untargeted nanoplatforms (4, 9). In practice, targeting NPs is far from trivial, and ongoing challenges include synthesis and purification, selection of an appropriate ligand receptor, and specific composition for NP conjugation. Even the conjugation reaction itself may alter the binding of the tumor-targeting moiety to its receptor through conformational changes, steric freedom restriction, or orientation distortion (10, 11). Unfortunately, the SignificanceThe main goal in the emerging field of cancer nanomedicine is to generate, standardize, and produce multifunctional carriers designed to improve the response of drugs against tumors. Here we report the design, development, and preclinical validation of a ligand-directed bioinorganic platform that integrates tumor targeting, receptor-mediated cell internalization, photon-to-heat conversion, and drug delivery. This enabling hydrogel-based technology can accommodate a broad variety of ligands, nanoparticles, and payloads. We show experimental proof-of-concept in mouse models of breast and prostate cancer with molecular imaging and marked reduct...

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“…These results may be highly beneficial for developing novel RF-assisted hyperthermic tools such as gold, iron oxide, metallic and semi-conductor-based nanoparticles. These may be useful for targeting eradication of many malignancies efficiently [52][53][54][55][56].…”

Section: Rf Heating Mechanism In Au-npsmentioning

confidence: 99%

Radio frequency responsive nano-biomaterials for cancer therapy

Rejinold

Jayakumar

Kim

2015

Journal of Controlled Release

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Temperature-triggered tumor-specific delivery of anticancer agents by cRGD-conjugated thermosensitive liposomes

Cited by 68 publications

References 25 publications

EGFR targeted thermosensitive liposomes: A novel multifunctional platform for simultaneous tumor targeted and stimulus responsive drug delivery

EGFR targeted thermosensitive liposomes: A novel multifunctional platform for simultaneous tumor targeted and stimulus responsive drug delivery

Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release

Radio frequency responsive nano-biomaterials for cancer therapy

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