Radio frequency responsive nano-biomaterials for cancer therapy

Rejinold, N. Sanoj; Jayakumar, R.; Kim, Yeu Chun

doi:10.1016/j.jconrel.2015.02.036

Cited by 49 publications

(28 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One such example of NaRFA is carbon based nanomaterials. Single-walled carbon nanotubes (SWNTs) can be modified to increase efficacy by improving specificity through surface engineering of SWNTs to have ligands, which can target receptors specific to cancer cells (40,41). In a study performed by Gannon et al RF exposure of SWNT caused cytotoxicity of cancer cells in vitro and in vivo while being well tolerated by rabbits bearing tumors.…”

Section: Nano-radio-frequency Ablation (Narfa)mentioning

confidence: 99%

See 1 more Smart Citation

Use of non-ionizing electromagnetic fields for the treatment of cancer

et al. 2018

View full text Add to dashboard Cite

Cancer treatment and treatment options are quite limited in circumstances such as when the tumor is inoperable, in brain cancers when the drugs cannot penetrate the blood-brain-barrier, or when there is no tumor-specific target for generation of effective therapeutic antibodies. Despite the fact that electromagnetic fields (EMF) in medicine have been used for therapeutic or diagnostic purposes, the use of non-ionizing EMF for cancer treatment is a new emerging concept. Here we summarize the history of EMF from the 1890's to the novel and new innovative methods that target and treat cancer by non-ionizing radiation.

show abstract

Section: Nano-radio-frequency Ablation (Narfa)mentioning

confidence: 99%

“…A second example can be found in Carbon coated metallic nanoparticles (C-Co-NPs). C-Co-NPs are 7-nm cubic crystalline graphitic carbon decorated ferromagnetic cobalt nanoparticles (40). These nanoparticles have been shown to effectively enter HeLa cells and when exposed to RF…”

Section: Nano-radio-frequency Ablation (Narfa)mentioning

confidence: 99%

Use of non-ionizing electromagnetic fields for the treatment of cancer

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Iron was chosen to facilitate ablation because it has been used in humans, and FeO nanoparticles have been studied in cancer therapeutics. 16,17 In addition, magnetic guidance of nanoparticles has been previously shown as a viable drug delivery system, including its use to direct ganglionic plexus toxicity. 18 Heat-sensitive liposomes can be utilized to systemically administer a pharmacological payload but yet have a localized effect by only releasing that payload on heat activation.…”

Section: Previous Investigations Into Ablation Of Nanoparticle-treatementioning

confidence: 99%

Enhanced Radiofrequency Ablation With Magnetically Directed Metallic Nanoparticles

Nguyen¹,

Tzou²,

Zheng³

et al. 2016

Circ: Arrhythmia and Electrophysiology

View full text Add to dashboard Cite

Background-Remote heating of metal located near a radiofrequency ablation source has been previously demonstrated.Therefore, ablation of cardiac tissue treated with metallic nanoparticles may improve local radiofrequency heating and lead to larger ablation lesions. We sought to evaluate the effect of magnetic nanoparticles on tissue sensitivity to radiofrequency energy. Methods and Results-Ablation was performed using an ablation catheter positioned with 10 g of force over prepared ex vivo specimens. Tissue temperatures were measured and lesion volumes were acquired. An in vivo porcine thigh model was used to study systemically delivered magnetically guided iron oxide (FeO) nanoparticles during radiofrequency application. Magnetic resonance imaging and histological staining of ablated tissue were subsequently performed as a part of ablation lesion analysis. Ablation of ex vivo myocardial tissue treated with metallic nanoparticles resulted in significantly larger lesions with greater impedance changes and evidence of increased thermal conductivity within the tissue. Magnet-guided localization of FeO nanoparticles within porcine thigh preps was demonstrated by magnetic resonance imaging and iron staining. Irrigated ablation in the regions with greater FeO, after FeO infusion and magnetic guidance, created larger lesions without a greater incidence of steam pops. Conclusions-Metal nanoparticle infiltration resulted in significantly larger ablation lesions with altered electric and thermal conductivity. In vivo magnetic guidance of FeO nanoparticles allowed for facilitated radiofrequency ablation without direct infiltration into the targeted tissue. Further research is needed to assess the clinical applicability of this ablation strategy using metallic nanoparticles for the treatment of cardiac arrhythmias. (Circ Arrhythm Electrophysiol. 2016;9:e003820.

show abstract

“…14 Rejinold et al summarized many nanomaterials (including gold nanomaterials), which can be used for RF hyperthermia in vitro. 15 However, the present study found that AuNRs with different aspect ratios (ARs) have different heating efficiencies induced by RF; therefore, in this study, AuNRs with a suitable AR were selected for RF-induced hyperthermia in vitro and in vivo.…”

Section: Introductionmentioning

confidence: 97%

Gold nanorod–based poly(lactic-co-glycolic acid) with manganese dioxide core–shell structured multifunctional nanoplatform for cancer theranostic applications

Wang¹,

Liu²,

Hao³

et al. 2017

IJN

View full text Add to dashboard Cite

Recently, photothermal therapy has become a promising strategy in tumor treatment. However, the therapeutic effect was seriously hampered by the low tissue penetration of laser. Therefore, in this study, radiofrequency (RF) with better tissue penetration was used for tumor hyperthermia. First, one type of gold nanorods (AuNRs) suitable for RF hyperthermia was selected. Then, poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with AuNRs and docetaxel (DTX) (PLGA/AuNR/DTX) NPs were constructed. Finally, manganese dioxide (MnO 2 ) ultrathin nanofilms were coated on the surfaces of PLGA/AuNR/DTX NPs by the reduction of KMnO 4 to construct the PLGA/AuNR/DTX@MnO 2 drug delivery system. This drug delivery system can not only be used for the combined therapy of chemotherapy and RF hyperthermia but can also produce Mn 2+ to enable magnetic resonance imaging. Furthermore, the RF hyperthermia and the degradation of MnO 2 can significantly promote the controlled drug release in a tumor region. The in vitro and in vivo results suggested that the PLGA/AuNR/DTX@MnO 2 multifunctional drug delivery system is a promising nanoplatform for effective cancer theranostic applications.

show abstract

Radio frequency responsive nano-biomaterials for cancer therapy

Cited by 49 publications

References 90 publications

Use of non-ionizing electromagnetic fields for the treatment of cancer

Use of non-ionizing electromagnetic fields for the treatment of cancer

Enhanced Radiofrequency Ablation With Magnetically Directed Metallic Nanoparticles

Gold nanorod–based poly(lactic-co-glycolic acid) with manganese dioxide core–shell structured multifunctional nanoplatform for cancer theranostic applications

Contact Info

Product

Resources

About

Radio frequency responsive nano-biomaterials for cancer therapy

Cited by 49 publications

References 90 publications

Use of non-ionizing electromagnetic fields for the treatment of cancer

Use of non-ionizing electromagnetic fields for the treatment of cancer

Enhanced Radiofrequency Ablation With Magnetically Directed Metallic Nanoparticles

Gold nanorod&ndash;based poly(lactic-co-glycolic acid) with manganese dioxide core&ndash;shell structured multifunctional nanoplatform for cancer theranostic applications

Contact Info

Product

Resources

About

Gold nanorod–based poly(lactic-co-glycolic acid) with manganese dioxide core–shell structured multifunctional nanoplatform for cancer theranostic applications