Temperature induced micellization and aggregation of biocompatible poly (oligo(ethylene glycol)methyl ether methacrylate) block copolymer analogs in aqueous solutions

Yao, Zhaoling; Tam, Kam Chiu

doi:10.1016/j.polymer.2012.06.002

Cited by 31 publications

(32 citation statements)

References 35 publications

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“…It is commonly accepted that the ratio of 0.77 represents the monodisperse hard spheres with constant density. Smaller than 0.77 indicates that a core–shell structure of the nanospheres was obtained, which is consistent with the morphology observed from TEM imaging (Figure b). In general these small values (<0.77) are characteristics for particles or micelles with a denser core and a less dense outer shell, and are considered to be the consequence of the surface layer of the particles or micelles.…”

Section: Resultssupporting

confidence: 86%

Preparation of pH‐Responsive Polymer Core–Shell Nanospheres for Delivery of Hydrophobic Antineoplastic Drug Ellipticine

Wang

Yang

Rempel

2013

Macromolecular Bioscience

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Antineoplastic drug ellipticine and its derivatives are used in human cancer therapy. However, their clinical applications have been limited by its great hydrophobicity and severe side effects. An efficient delivery system is therefore very desirable. In this research, an ellipticine-loaded core-shell structured nanosphere namely poly(DEAEMA)-poly(PEGMA) is designed as a drug carrier and prepared via a two-step semibatch emulsion polymerization method where DEAEMA and PEGMA represent 2-(diethylamino)ethyl methacrylate and poly(ethylene glycol) methacrylate, respectively. The in-vitro release profiles of ellipticine towards the different pH liposome vesicles are recorded as a function of time at 37 °C. It is found that release of ellipticine from the core-shell polymer matrix is a pH-responsive and controlled release process. The three pH's of 3, 4, and 5 trigger a significant ellipticine release of 88% after 98 h, 83% after 98 h, and 79% after 122 h, respectively. The release mechanism of ellipticine from the core-shell polymer matrix under acidic conditions is explored. The synthesis and encapsulation process developed herein provides a new perspective for the development of appropriate delivery systems to deliver the ellipticine and its analogues, as well as other types of hydrophobic drugs to a given target cell or tumor tissue.

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Section: Resultssupporting

confidence: 86%

Preparation of pH‐Responsive Polymer Core–Shell Nanospheres for Delivery of Hydrophobic Antineoplastic Drug Ellipticine

Wang

Yang

Rempel

2013

Macromolecular Bioscience

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“…[ 28,29 ] Subsequently, a variety of polymer brushes, micelles, vesicles, micro/nanogels, as well as a few of smart hydrogels based on POEGMA have been developed in the past few years. [30][31][32][33] For instance, Huck and co-workers reported that surface attached P(MEO 2 MA -co-OEGMA) brushes exhibited a fast and reversible thermo-induced collapse transition, resulting in different surface properties of the polymer coating below and above the LCST. [ 34 ] Roth et al showed that POEGMA based copolymers also exhibit a UCST behavior in alcohol/ water mixtures.…”

Section: Introductionmentioning

confidence: 99%

Thermo‐Induced Double Phase Transition Behavior of Physically Cross‐Linked Hydrogels Based on Oligo(ethylene glycol) methacrylates

Cheng

Théato

Zhu

2015

Macro Chemistry & Physics

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Double thermosensitive clay/P(MEO 2 MA -co-POEGMA) nanocomposite (NC) hydrogels are prepared by in situ free radical polymerization of 2-(2-methoxyethoxy) ethyl methacrylate (MEO 2 MA) and oligo(ethylene glycol) methacrylate (OEGMA) in the presence of physical crosslinker clay. The temperature-induced phase transition behavior of NC hydrogels is investigated by turbidity, temperature dependent nuclear magnetic resonance, and variable temperature Fourier transform infrared spectroscopy. 2D infrared analysis is employed to study the sequential order of changes of all groups in NC hydrogels during the heating and cooling process. The obtained novel clay/P(MEO 2 MA -co-POEGMA) NC hydrogels exhibit an unusual thermally induced multistep aggregation process and successively undergo three consecutive microstructural changes: "loose clay/polymer microaggregation ↔ homogeneous network structure ↔ dense clay/polymer macroaggregation." Dynamic light scattering and transmission electron microscopy measurements show similar results of the NC nanogel at the same temperature regions, confi rming the three consecutive microstructural changes. This new generation of thermosensitive hydrogel offers promising potential for applications as smart devices, biomedical materials, and drug carriers.

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“…Therefore, the value of N agg for P 296 D 1 was smaller than that for P 98 D 3 . The R g / R h ratios for P 98 D 3 and P 296 D 1 were the same (1.10), suggesting that they have a spherical shape …”

Section: Resultsmentioning

confidence: 91%

Preparation of amphiphilic diblock copolymers with pendant hydrophilic phosphorylcholine and hydrophobic dendron groups and their self-association behavior in water

Osawa

Imae

Ujihara

et al. 2013

J. Polym. Sci. Part A: Polym. Chem.

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Generation 3.5 poly(amido amine) dendron (G3.5) with 16 n‐butyl terminal groups containing an acrylamide monomer (AaUG3.5) was prepared by condensation between an amino focal group in G3.5 and 11‐acrylamidoundecanoic acid. AaUG3.5 was polymerized using poly(2‐methacryloyloxyethyl phosphorylcholine) (pMPC)‐based macro‐chain transfer agent via reversible addition‐fragmentation chain transfer (RAFT) radical polymerization to obtain amphiphilic diblock copolymers with different compositions. The diblock copolymers (PmDn) were composed of a hydrophilic pMPC block and hydrophobic pendant dendron‐bearing block, where P and D represent pMPC and pAaUG3.5, respectively, and m and n represent the degree of polymerization for each block, respectively. P296D1 and P98D3 formed vesicles and large compound micelles and vesicles, respectively, which was confirmed by light scattering measurements and transmission electron microscopic (TEM) observations. The large compound micelles formed from P98D3 could not incorporate hydrophilic guest polymer molecules, because the aggregates did not have a hydrophilic hollow core. In contrast, the vesicles formed from P269D1 could incorporate hydrophilic guest polymer molecules into the hollow core. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 4923–4931

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Temperature induced micellization and aggregation of biocompatible poly (oligo(ethylene glycol)methyl ether methacrylate) block copolymer analogs in aqueous solutions

Cited by 31 publications

References 35 publications

Preparation of pH‐Responsive Polymer Core–Shell Nanospheres for Delivery of Hydrophobic Antineoplastic Drug Ellipticine

Preparation of pH‐Responsive Polymer Core–Shell Nanospheres for Delivery of Hydrophobic Antineoplastic Drug Ellipticine

Thermo‐Induced Double Phase Transition Behavior of Physically Cross‐Linked Hydrogels Based on Oligo(ethylene glycol) methacrylates

Preparation of amphiphilic diblock copolymers with pendant hydrophilic phosphorylcholine and hydrophobic dendron groups and their self-association behavior in water

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