Preparation of amphiphilic diblock copolymers with pendant hydrophilic phosphorylcholine and hydrophobic dendron groups and their self-association behavior in water

Abstract

Generation 3.5 poly(amido amine) dendron (G3.5) with 16 n‐butyl terminal groups containing an acrylamide monomer (AaUG3.5) was prepared by condensation between an amino focal group in G3.5 and 11‐acrylamidoundecanoic acid. AaUG3.5 was polymerized using poly(2‐methacryloyloxyethyl phosphorylcholine) (pMPC)‐based macro‐chain transfer agent via reversible addition‐fragmentation chain transfer (RAFT) radical polymerization to obtain amphiphilic diblock copolymers with different compositions. The diblock copolymers (PmDn) were composed of a hydrophilic pMPC block and hydrophobic pendant dendron‐bearing block, where P and D represent pMPC and pAaUG3.5, respectively, and m and n represent the degree of polymerization for each block, respectively. P296D1 and P98D3 formed vesicles and large compound micelles and vesicles, respectively, which was confirmed by light scattering measurements and transmission electron microscopic (TEM) observations. The large compound micelles formed from P98D3 could not incorporate hydrophilic guest polymer molecules, because the aggregates did not have a hydrophilic hollow core. In contrast, the vesicles formed from P269D1 could incorporate hydrophilic guest polymer molecules into the hollow core. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 4923–4931

A Comparative Study of Cellular Uptake and Subcellular Localization of Doxorubicin Loaded in Self‐Assemblies of Amphiphilic Copolymers with Pendant Dendron by MDA‐MB‐231 Human Breast Cancer Cells

“…The diblock copolymers P 71 D 3 and P 296 D 1 (see Scheme ) were the same samples as those previously synthesized . Micelles (hydrodynamic diameter: 65 nm, transmission electron microscopic (TEM) diameter: 70.5 nm) of P 71 D 3 (molecular weight: 2.60 × 10 6 ) were formed by 104 molecules .…”

“…Micelles (hydrodynamic diameter: 65 nm, transmission electron microscopic (TEM) diameter: 70.5 nm) of P 71 D 3 (molecular weight: 2.60 × 10 6 ) were formed by 104 molecules . P 296 D 1 (molecular weight: 2.20 × 10 7 ) formed vesicles (hydrodynamic diameter: 230 nm, TEM diameter: 240 nm) consisting of 241 molecules . The aggregation number was calculated by dividing the molecular weight of the aggregate by the molecular weight of a single polymer chain …”

“…P 296 D 1 (molecular weight: 2.20 × 10 7 ) formed vesicles (hydrodynamic diameter: 230 nm, TEM diameter: 240 nm) consisting of 241 molecules . The aggregation number was calculated by dividing the molecular weight of the aggregate by the molecular weight of a single polymer chain …”

“…Another amphiphilic diblock copolymer was composed of a hydrophilic pendant phosphorylcholine moiety and hydrophobic amido amine‐type dendron side chain moiety . The polymer (P 296 D 1 ) formed vesicles in water, which was mostly likely due to its rod‐like shape, with side chains on both blocks (Scheme ).…”

Block copolymers in the synthesis of gold nanoparticles. Two new approaches: Copolymer aggregates as reductants and stabilizers and simultaneous formation of copolymer aggregates and gold nanoparticles

“…However, it is well known that certain block copolymers that contain hydrophobic and hydrophilic segments are capable of self‐assembling to generate a variety of nanostructures in a specific medium . Additionally, the amphiphilic characteristics of some copolymers and their ability to interact with nanoparticles or form aggregates on nanoparticle surfaces promotes the stability of nanoparticles suspensions.…”