Temperature increase induced by modulated electrohyperthermia (oncothermia^®) in the anesthetized pig liver

Modulated electrohyperthermia in locally advanced cervical cancer: Results of an observational study of 95 patients

“…[16] Oncothermia is a modular electrohyperthermia based on energy dose control instead of a single parameter of temperature, and this method accurately selects only tumor cells and heats them to transfer a definite energy dose to more effectively lead to apoptotic cell death without unwanted physiologic consequences. [11] Using anesthetized living pigs, Balogh et al [19] reported that 13.56 MHz-modulated RF can increase the temperature by 3 to 5°C in deep tissue. Kim et al [24] reported that mild temperature hyperthermia suppresses hypoxia-inducible factor-1a (HIF-1a) and vascular endothelial growth factor (VEGF), which are upregulated under hypoxic conditions.…”

“…It is also notably gentle, and its use on brain malignancies has been successful, [19][20][21] even at increased doses for advanced cases. [12] In the present study, we analyzed whether there was a better treatment by analyzing the treatment results and recurrence rates of the 2 treatment groups that underwent CCRT alone or CCRT + mEHT for locally advanced cervical cancer.…”

“…This method uses a modulated RF for energy delivery and achieves selective thermal action in nonhomogeneous tissue. [18] It is also notably gentle, and its use on brain malignancies has been successful, [19–21] even at increased doses for advanced cases. [12]…”