Immunogenic Effect of Modulated Electro-hyperthermia (mEHT) in Solid Tumors

Lee, Sun-Young; Szász, András

doi:10.1007/16833_2022_74

Cited by 7 publications

(8 citation statements)

References 122 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The local treatment developed a whole-body effect by mEHT [230] (Figure 10). The in-situ and real-time production of tumor-specific immune activity is the advantage of mEHT [231].…”

Section: Immune Effectsmentioning

confidence: 99%

The Immunogenic Connection of Thermal and Nonthermal Molecular Effects in Modulated Electro-Hyperthermia

Szász,

Lóránt,

Szász

et al. 2023

OJBIPHY

View full text Add to dashboard Cite

Hyperthermia in oncology is an emerging complementary therapy. The clinical results depend on multiple conditional factors, like the type of cancer, the stage, the applied treatment device, and the complementary conventional therapy. The molecular effect could also be different depending on the temperature, heating dose, kind of energy transfer, and timing sequences compared to the concomitant treatment. This article examines the molecular impacts of a specific technique used in oncological hyperthermia called modulated electro-hyperthermia (mEHT). What sets mEHT apart is its emphasis on harnessing the combined effects of thermal and nonthermal factors. Nonthermal energy absorption occurs through the excitation of molecules, while the thermal component ensures the ideal conditions for this process. The applied radiofrequency current selects the malignant cells, and the modulation drives the nonthermal effects to immunogenic cell death, helping to develop tumor-specific antitumoral immune reactions. The synergy of the thermal and nonthermal components excites the lipid-assembled clusters of transmembrane proteins (membrane rafts) as the channels of transient receptor potentials (TRPs), the heat-shock proteins (HSPs), the voltage-gated channels, and the voltage-sensitive phosphatases (VSPs). All these transmembrane compartments channeling various ionic species (like calcium and proton) interact with the cytoskeleton and are involved in the apoptotic signal pathways.

show abstract

“…The local treatment developed a whole-body effect by mEHT [230] (Figure 10). The in-situ and real-time production of tumor-specific immune activity is the advantage of mEHT [231].…”

Section: Immune Effectsmentioning

confidence: 99%

The Immunogenic Connection of Thermal and Nonthermal Molecular Effects in Modulated Electro-Hyperthermia

Szász,

Lóránt,

Szász

et al. 2023

OJBIPHY

View full text Add to dashboard Cite

show abstract

“…The selection of the malignant cells uses the microscopic natural heterogeneities of the tumor. The applied electric field has different interactions with the cancerous and healthy cells in four basic characteristics, Figure 1 , discussed in multiple publications [ 8 , 9 , 10 , 11 , 12 ]: Due to the intensive metabolism of the malignant cells, the ionic species of the nutrients and waste molecules (such as lactate) have high concentrations in the tumor microenvironment (TME), and together with the extended volume of the extracellular matrix (ECM), create a significantly higher electric conductivity of the microenvironment of malignant cells and the entire tumor [ 13 , 14 ]. This conduction difference drives the RF current to the area [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

The Clinical Validation of Modulated Electro-Hyperthermia (mEHT)

Lee,

Lorant,

Grand

et al. 2023

Cancers

Self Cite

View full text Add to dashboard Cite

The mEHT method uses tissues’ thermal and bioelectromagnetic heterogeneity for the selective mechanisms. The success of the therapy for advanced, relapsed, and metastatic aggressive tumors can only be demonstrated by measuring survival time and quality of life (QoL). The complication is that mEHT-treated patients cannot be curatively treated any longer with “gold standards”, where the permanent progression of the disease, the refractory, relapsing situation, the organ failure, the worsening of blood counts, etc., block them. Collecting a cohort of these patients is frequently impossible. Only an intent-to-treat (ITT) patient group was available. Due to the above limitations, many studies have single-arm data collection. The Phase III trial of advanced cervix tumors subgrouping of HIV-negative and -positive patients showed the stable efficacy of mEHT in all patients’ subgroups. The single-arm represents lower-level evidence, which can be improved by comparing the survival data of various studies from different institutes. The Kaplan–Meier probability comparison had no significant differences, so pooled data were compared to other methods. Following this approach, we demonstrate the feasibility and superiority of mEHT in the cases of glioblastoma multiform, pancreas carcinomas, lung tumors, and colorectal tumors.

show abstract

“…The applied power and absorbed energy are shared by thermal and nonthermal processes, offering the clinical advantage of a moderate thermal component. This optimum balance reduces the risk of adverse thermal effects, inducing patient discomfort, while exerting numerous antitumoral immunogenic effects, killing tumor cells via programmed cell death and leading to tumor-specific immune reactions [84].…”

mentioning

confidence: 99%

“…Relief of pain intensity was better in complementary HT with RT than in monotherapy, and pain relief lasted longer in the HT + RT group. Moreover, HT, as a complementary adjuvant, has immunogenic activity [84,91].…”

mentioning

confidence: 99%

Treatment of Pelvic and Spinal Bone Metastases: Radiotherapy and Hyperthermia Alone vs. in Combination

Kim,

Shin,

Lee

2024

Cancers

View full text Add to dashboard Cite

Painful pelvic and spinal bone metastases are a considerable challenge for doctors and patients. Conventional therapies include morphine-equivalent medication (MeM) and local radiotherapy (RT), but these interventions are not always successful. More recently, hyperthermia (HT) has been applied to complement RT and MeM, and this complex approach has shown promising synergistic results. The objective of our study was to present the results of RT combined with a special kind of HT (modulated electrohyperthermia, mEHT), in which some of the thermal effect is contributed by equivalent nonthermal components, drastically reducing the necessary power and energy. This retrospective study included 61 patients divided into three groups with pelvic and spinal bone metastases to compare the effects of RT and mEHT alone and in combination (RT + mEHT). A detailed evaluation of pain intensity, measured by the brief pain inventory score, MeM use, and breakthrough pain episodes, revealed no significant differences between RT and mEHT alone; thus, these individual methods were considered equivalent. However, RT + mEHT yielded significantly better results in terms of the above parameters. Clinically, mEHT has a lower risk of adverse thermal effects, and due to its efficacy, mEHT can be used to treat RT-resistant lesions.

show abstract

Immunogenic Effect of Modulated Electro-hyperthermia (mEHT) in Solid Tumors

Cited by 7 publications

References 122 publications

The Immunogenic Connection of Thermal and Nonthermal Molecular Effects in Modulated Electro-Hyperthermia

The Immunogenic Connection of Thermal and Nonthermal Molecular Effects in Modulated Electro-Hyperthermia

The Clinical Validation of Modulated Electro-Hyperthermia (mEHT)

Treatment of Pelvic and Spinal Bone Metastases: Radiotherapy and Hyperthermia Alone vs. in Combination

Contact Info

Product

Resources

About