Temperature-driven braking of γ-cyclodextrin-curcubit[6]uril-cowheeled [4]rotaxanes

Multicharged cyclodextrin supramolecular assemblies

“…However, components of the guest molecules such as polymer chains, azobenzene, ferrocene, adamantane, and hydrophobic drugs can also be modified with charged groups to improve their host-guest interactions with CDs. The exposed charges can be exploited to induce co-assembly with oppositely charged molecules through electrostatic interactions, as well as multilevel assembly with other supramolecular macrocycles such as charged calixarenes, 140,141 cucurbit[n]urils (CB[n]s), [142][143][144][145] and charged pillar[n]arenes, 146,147 which are conducive to constructing multifunctional supramolecular assemblies, such as rotaxanes [148][149][150] and hydrogels, [151][152][153][154][155] applied in the field of electrophoresis. [156][157][158][159][160] Although the literature contains numerous reviews covering the diverse applications of CDs and CD-based assemblies, including metal complexation, 11,41,161,162 cyclodextrin metal-organic frameworks, 163 cyclodextrin covalent organic frameworks, [164][165][166][167] supramolecular catalysis and synthesis, [168][169][170] multistimuliresponsive materials, 15,[171][172][173] polymer materials, 13,24,[174]…”

Solvent-Driven Chirality Switching of a Pillar[4]arene[1]quinone Having a Chiral Amine-Substituted Quinone Subunit

“…Compared with molecular chirality, the supramolecular chirality is more attractive in terms of their regulatability by the external conditions such as temperature ( Yao et al, 2017 ; Fan et al, 2019 ), pH ( Kanagaraj et al, 2020 ; Liang et al, 2020 ; Hao et al, 2021 ), redox ( Xiao et al, 2020 ), light ( De Poli et al, 2016 ), chemical additives ( Lee et al, 2018 ), pressure ( Yao et al, 2021a ), and solvents ( Borovkov et al, 2003b ; Fan et al, 2019 ). Pillar[n]arenes ( Ogoshi et al, 2008 ; Xue et al, 2012 ; Pan et al, 2015 ; Fan et al, 2016 ; Jie et al, 2018 ; Lv et al, 2018 ; Li G. et al, 2019 ; Xiao et al, 2019 ; Ji et al, 2020a ; Lou and Yang, 2020 ; Mi et al, 2020 ; Liu et al, 2021 ; Peng et al, 2021 ), as a relatively new class of synthetic macrocyclic hosts with some unique properties ( Guo et al, (2018) ; Lai et al, (2019) ; Liu et al, (2019) ; Wang et al, (2021 ), have proved to be an ideal platform to construct unimolecular chirality based on different external stimuli-driven. We have demonstrated that the chirality of pillar[n]arene derivatives could be manipulated by external stimuli, including temperature, redox, light, and pressure ( Yao et al, 2017 ; Xiao et al, 2020 ; Yao et al, 2021a ; Yao et al, 2021b ).…”

Advances in Chirality Sensing with Macrocyclic Molecules

“…Cyclodextrins are inherently chiral macrocyclic molecules that show antidifferentiation in photoreactions and supramolecular complexation [58][59][60][61]. Yang and co-workers have proposed an intriguing strategy to construct chiral cavities by implanting an achiral axis into the large chiral cavity of γ-cyclodextrin through rotaxanation [62][63][64][65]. The implanting aromatic axis plays the role of a spacer that changes the round shape of native cyclodextrin and provides π−π interaction with the incoming chiral guest.…”