Temperature dependency of human muscle velocity recovery cycles

Bostock, Hugh; Baumann, Corina; Humm, Andrea M.; Z'Graggen, Werner Josef

doi:10.1002/mus.23429

Cited by 12 publications

(6 citation statements)

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“…Because of this sensitivity of MRRP, all the MRRP values were corrected to the mean control temperature of 37.9°C before making statistical comparisons, using the relationship for the 40 control recordings (MRRP = 12.0 - 0.253.T; Pearson R = −0.54, P = 0.00057)). In contrast to the high sensitivity of MRRP to temperature, ESN is relatively insensitive to temperature changes ( R = 0.225, P = 0.17) as found previously [23]. …”

Section: Methodssupporting

confidence: 76%

“…There is a known significant dependency of MRRP measurements on body muscle temperature, which varied from 36.3 to 39.8°C in the control pigs and from 33.8°C to 39.7°C in the peritonitis group [23]. Because of this sensitivity of MRRP, all the MRRP values were corrected to the mean control temperature of 37.9°C before making statistical comparisons, using the relationship for the 40 control recordings (MRRP = 12.0 - 0.253.T; Pearson R = −0.54, P = 0.00057)).…”

Section: Methodsmentioning

confidence: 99%

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Early changes of muscle membrane properties in porcine faecal peritonitis

et al. 2014

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IntroductionSepsis-induced myopathy and critical illness myopathy (CIM) are possible causes of muscle weakness in intensive care patients. They have been attributed to muscle membrane dysfunction. The aim of this study was to investigate membrane properties in the early stage of experimental sepsis by evaluating muscle excitability.MethodsIn total, 20 anaesthetized and mechanically ventilated pigs were randomized to either faecal peritonitis (n = 10) or to non-septic controls (n = 10). Resuscitation with fluids and vasoactive drugs was started 3 hours after peritonitis induction. Muscle membrane properties were investigated by measuring muscle velocity recovery cycles before induction of peritonitis as well as 6, 18 and 27 hours thereafter. Muscle relative refractory period (MRRP) and early supernormality (ESN) were assessed.ResultsPeritonitis lasting 27 hours was associated with an increase of MRRP by 28% from 2.38 ± 0.18 ms (mean ± SD) to 3.47 ± 1.79 ms (P <0.01) and a decrease of ESN by 31% from 9.64 ± 2.82% to 6.50 ± 2.64% (P <0.01). ESN reduction was already apparent 6 hours after induction of peritonitis. Values in controls did not show any significant alterations.ConclusionsMuscle membrane abnormalities consistent with membrane depolarization and/or sodium channel inactivation occurred within 6 hours of peritonitis induction. This indicates that changes that have been described in established sepsis-induced myopathy and/or CIM start early in the course of sepsis. Muscle excitability testing facilitates evaluation of the time course of these changes.Electronic supplementary materialThe online version of this article (doi:10.1186/s13054-014-0484-2) contains supplementary material, which is available to authorized users.

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Section: Methodssupporting

confidence: 76%

Section: Methodsmentioning

confidence: 99%

Early changes of muscle membrane properties in porcine faecal peritonitis

et al. 2014

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“…Temperature has been found to affect muscle excitability parameters, with lower temperatures leading to prolongation of the MRRP . In our study cohort, no confounding relationship was observed between age and skin temperature at the recording site for any of the significant relationships reported, despite correction for this variable, as detailed previously.…”

Section: Discussionsupporting

confidence: 75%

Sarcolemmal excitability changes in normal human aging

Lee

Boland-Freitas

2018

Muscle and Nerve

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“…The overlap of the MVRCs following single stimuli in Figure A suggest that resting potentials were similar in the 3 groups, and this is supported by the similar values of relative refractory period (MRRP) in Table . MRRP is affected by temperature, so it is important to note that skin temperatures overlying the muscle were closely matched between groups (NC 29.9 ± 1.2°C, DM1 30.0 ± 1.3°C, DM2 30.4 ± 0.6°C).…”

Section: Resultsmentioning

confidence: 97%

In vivo assessment of muscle membrane properties in myotonic dystrophy

et al. 2016

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Introduction Myotonia in myotonic dystrophy types 1 (DM1) and 2 (DM2) is generally attributed to reduced chloride channel conductance. We used muscle velocity recovery cycles (MVRCs) to investigate muscle membrane properties in DM1 and DM2, with comparisons with myotonia congenita (MC). Methods MVRCs and responses to repetitive stimulation were compared between patients with DM1 (n=18), DM2 (n=5), MC (n=18), and normal controls (n=20). Results Both DM1 and DM2 showed enhanced late supernormality after multiple conditioning stimuli, indicating delayed repolarization as in MC. Contrary to MC, however, DM1 showed reduced early supernormality after multiple conditioning stimuli, and weak DM1 patients also showed abnormally slow latency recovery after repetitive stimulation. Discussion These findings support impaired chloride conductance in both DM1 and DM2. The early supernormality changes indicate that sodium currents were reduced in DM1, while the weakness-associated slow recovery after repetitive stimulation may provide an indication of reduced Na+/K+-ATPase activation.

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Temperature dependency of human muscle velocity recovery cycles

Abstract: Knowledge of temperature-induced changes of muscle VRC parameters is essential for future studies. Thus, the results of this study provide a firm basis for clinical studies with this technique.

Cited by 12 publications

References 10 publications

Early changes of muscle membrane properties in porcine faecal peritonitis

Early changes of muscle membrane properties in porcine faecal peritonitis

Sarcolemmal excitability changes in normal human aging

In vivo assessment of muscle membrane properties in myotonic dystrophy

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