Sarcolemmal excitability changes in normal human aging

Lee, James H. F.; Boland-Freitas, Robert; Ng, Karl

doi:10.1002/mus.26058

Cited by 12 publications

(9 citation statements)

References 54 publications

(102 reference statements)

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“…MVRC recordings were made from the distal 25% of RF and near the distal palpated end of TA to avoid the motor points. Recordings of both muscles were performed in series within 2 hours in each subject, as described elsewhere …”

Section: Methodsmentioning

confidence: 99%

“…The electrophysiological technique of multifiber muscle velocity cycle recording (MVRC), as described in previous work, is a reliable and repeatable technique that has been used to examine sarcolemmal excitability properties in physiological and disease states in vivo . No significant differences in MVRC parameters have been described in the limited studies comparing normal human muscles using this technique .…”

Section: Introductionmentioning

confidence: 99%

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Physiological differences in sarcolemmal excitability between human muscles

Lee

Boland-Freitas

2019

Muscle and Nerve

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Introduction The sarcolemmal resting membrane potential (RMP) affects muscle excitability, contractility, and force generation. However, there are limited In vivo data on the normal RMP of the human sarcolemma between muscles. We hypothesize that the in vivo RMP may differ between human muscles with different physiological roles. Methods Muscle velocity recovery cycles were recorded from a proximal antigravity muscle, the rectus femoris, and compared with paired recordings from a distal non‐antigravity muscle, the tibialis anterior, in 34 normal individuals. Results Significant differences in muscle relative refractory period (3.55 millseconds vs 3.87 milliseconds, P = .002), early supernormality (14.22% vs 10.50%, P < .0001), and late supernormality (5.43% vs 3.50%, P < .0001) were observed. Discussion The results strongly suggest a less negative RMP in tibialis anterior vs rectus femoris and attest to intermuscle differences in normal excitability and physiology. This novel finding employing an in vivo methodology highlights the need for muscle‐specific normative data in future studies.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Physiological differences in sarcolemmal excitability between human muscles

Lee

Boland-Freitas

2019

Muscle and Nerve

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“…Recordings of both muscles were performed in series within 2 hours in each subject, as described elsewhere. 5 In a small subset of the cohort (n = 5), MVRC recordings at rest were attempted in the soleus in addition to TA and RF within the same recording session. Soleus was identified by palpation and identification of the Achilles tendon and the gastrocnemius, with recordings performed medial to the Achilles tendon but distal to the end of the medial gastrocnemius.…”

Section: Study Protocolmentioning

confidence: 99%

“…The electrophysiological technique of multifiber muscle velocity cycle recording (MVRC), as described in previous work, 3 is a reliable and repeatable technique 4 that has been used to examine sarcolemmal excitability properties in physiological 3,5 and disease states in vivo. 6,7 No significant differences in MVRC parameters have been described in the limited studies comparing normal human muscles using this technique.…”

Section: Introductionmentioning

confidence: 99%

Nerve entrapments related to muscle herniation

2019

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Background Muscle herniation is a muscle protrusion through a fascial defect. It is a rarely reported cause of nerve entrapment. Methods We present a case of superficial fibular (peroneal) neuropathy associated with a fibularis (peroneus) brevis muscle herniation and a review of the literature on nerve entrapments secondary to muscle herniation unrelated to compartment syndrome. Results Eleven cases of nerve entrapments secondary to muscle herniation were identified. The superficial fibular nerve (SFN) was the most commonly entrapped nerve by fibularis muscle herniation. Patients presented with pain, numbness, or paresthesias, and an often tender, small palpable mass with a Tinel sign. Muscle MRI or ultrasound identified the lesion, and patients responded well to fasciotomy. Conclusions The most commonly reported nerve entrapped by muscle herniation is the SFN secondary to fibularis muscle herniation. Characteristic clinical and imaging (MRI or ultrasound) features are diagnostic, and there is a salutary response to fasciotomy.

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“…However, Z'Graggen and Bostock later found that multi-fiber recordings, obtained by direct stimulation and recording from the same bundle of muscle fibers, provide a fast and simple method of obtaining such recordings in vivo 7 . A sequence of paired pulse electrical stimuli with varying interstimulus intervals (ISIs) is used in this method 7,8,9,10,11 .…”

Section: Introductionmentioning

confidence: 99%

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties

Witt

Bostock

Z'Graggen

et al. 2020

JoVE

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Although conventional nerve conduction studies (NCS) and electromyography (EMG) are suitable for the diagnosis of neuromuscular disorders, they provide limited information about muscle fiber membrane properties and underlying disease mechanisms. Muscle velocity recovery cycles (MVRCs) illustrate how the velocity of a muscle action potential depends on the time after a preceding action potential. MVRCs are closely related to changes in membrane potential that follow an action potential, thereby providing information about muscle fiber membrane properties. MVRCs may be recorded quickly and easily by direct stimulation and recording from multi-fiber bundles in vivo. MVRCs have been helpful in understanding disease mechanisms in several neuromuscular disorders. Studies in patients with channelopathies have demonstrated the different effects of specific ion channel mutations on muscle excitability. MVRCs have been previously tested in patients with neurogenic muscles. In this prior study, muscle relative refraction period (MRRP) was prolonged, and early supernormality (ESN) and late supernormality (LSN) were reduced in patients compared to healthy controls. Thereby, MVRCs can provide in vivo evidence of membrane depolarization in intact human muscle fibers that underlie their reduced excitability. The protocol presented here describes how to record MVRCs and analyze the recordings. MVRCs can serve as a fast, simple, and useful method for revealing disease mechanisms across a broad range of neuromuscular disorders.

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Sarcolemmal excitability changes in normal human aging

Abstract: The results are consistent with progressive depolarization of the resting sarcolemmal potential with normal aging. This may be an important mechanism in explaining age-related muscle decline. Muscle Nerve 57: 981-988, 2018.

Cited by 12 publications

References 54 publications

Physiological differences in sarcolemmal excitability between human muscles

Physiological differences in sarcolemmal excitability between human muscles

Nerve entrapments related to muscle herniation

Muscle Velocity Recovery Cycles to Examine Muscle Membrane Properties

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