Temperature dependence of thermal conductivity of biological tissues

Bhattacharya, Anandaroop; Mahajan, Roop L.

doi:10.1088/0967-3334/24/3/312

Cited by 151 publications

(112 citation statements)

References 25 publications

(19 reference statements)

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“…In a previous report [29], the conductivity of collagenous tissue was estimated to be $0.65 W/m K below 558C and $0.70 W/m K at 658C. The ECM portion of the bandage remained at low temperature ($308C) during laser irradiation due to poor heat conduction and therefore constituent proteins (collagen, fibronecting and laminen) or growth factors (e.g.…”

Section: Discussionmentioning

confidence: 97%

Integration of extracellular matrix with chitosan adhesive film for sutureless tissue fixation

Lauto

2009

Lasers Surg Med

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Background and ObjectivesExtracellular matrices (ECMs) are currently applied in reconstructive surgery to enhance wound healing and tissue remodelling. Sutures and staples are usually employed to stabilize ECM on tissue although they may damage the matrix structure. In this investigation, a novel biocompatible bandage was developed to fix ECM on tissue without sutures.Study Design/Materials and MethodsAn adhesive film, based on chitosan, was integrated with small intestine submucosa (SIS) in a single bandage strip. This bandage was bonded to sheep small intestine upon laser irradiation of the chitosan film (P = 0.12 W, Fluence = 46±1 J/cm2) to assess tissue adhesion strength. Thermocouples were used to estimate temperatures under SIS during laser irradiation. Bandage strips were also mechanically tested to evaluate their tensile strength before and after irradiation.Results and ConclusionsThe bandage successfully bonded to intestine achieving a shear stress of 9.6± 1.6 kPa (n = 15). During laser irradiation, the temperature increased modestly to 31±2°C (n = 14) beneath the ECM portion of the bandage. The bandage withstood a tensile strength of 3,122±780 and 3,384±791 kPa, before and after laser irradiation respectively (n = 10, P = 0.47, t‐test). The SIS‐chitosan bandage bonded effectively to tissue without sutures and preserved the ECM structure avoiding irreversible thermal denaturation of imbedded bioactive proteins. Lasers Surg. Med. 41:366–371, 2009. © 2009 Wiley‐Liss, Inc.

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Section: Discussionmentioning

confidence: 97%

Integration of extracellular matrix with chitosan adhesive film for sutureless tissue fixation

Lauto

2009

Lasers Surg Med

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“…In our study on the other hand, the voltage is switched on ( on ) until the maximum temperature in the tissue reaches a certain value. As irreversible effects for the material properties start to appear at around 90 ∘ C [20], we limit the maximum temperature during RFA treatment to 80 ∘ C to avoid inaccurate modeling. Subsequently, the voltage is switched off during a fixed period .…”

Section: B Monopolar and Bipolar Rfamentioning

confidence: 99%

Coupled electrical-thermal model for monopolar and bipolar radiofrequency liver tumor ablation

Soetaert

Crevecoeur

Dupré

2016

2016 International Symposium on Fundamentals of Electrical Engineering (ISFEE)

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Abstract-Radiofrequency ablation (RFA) is an alternative cancer treatment that applies radiofrequency electric fields to biological tissues. The subsequent electrical currents induce Joule heating and inflict local thermal damage to the biological tissue. Previous clinical studies demonstrate the possibilities and benefits of applying RFA for the treatment of liver tumors. Currently, most clinical studies focus on monopolar RFA, consisting of a single electrode and a grounding pad, and its therapeutical outcome. This study however focuses on a bipolar configuration where two needle electrodes are inserted at a certain potential difference. In order to assess the temperature elevations in biological tissues, we have developed a computational model. A mathematical model based on Laplace's equation (with appropriate boundary conditions) is used to model the electromagnetic phenomena and is coupled to the bioheat transfer equation. This study compares a monopolar RFA with a bipolar configuration. We investigate the spatio-temporal temperature variations using detailed numerical three-dimensional finite element simulations in biological tissues, corresponding to liver tissue. Results show that the ablated region in between the two needles of the bipolar configuration can be enlarged compared to a monopolar RFA configuration.

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“…The stiffness of objects can also be measured by using fingertips, in this case, by pressing objects (Lederman 1981). The thermal conductivity can be perceived by making lightly contact the finger with the objects' surfaces (Bhattacharya and Mahajan 2003).…”

Section: Introductionmentioning

confidence: 99%

Tactile-based active object discrimination and target object search in an unknown workspace

et al. 2018

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The tasks of exploring unknown workspaces and recognizing objects based on their physical properties are challenging for autonomous robots. In this paper, we present strategies solely based on tactile information to enable robots to accomplish such tasks. (1) An active exploration approach for the robot to explore unknown workspaces; (2) an active touch objects learning method that enables the robot to learn efficiently about unknown objects via their physical properties (stiffness, surface texture, and center of mass); and (3) an active object recognition strategy, based on the knowledge the robot has acquired. Furthermore, we propose a tactile-based approach for estimating the center of mass of rigid objects. Following the active touch for workspace exploration, the robotic system with the sense of touch in fingertips reduces the uncertainty of the workspace up to 65 and 70% compared respectively to uniform and random strategies, for a fixed number of samples. By means of the active touch learning method, the robot achieved 20 and 15% higher learning accuracy for the same number of training samples compared to uniform strategy and random strategy, respectively. Taking advantage of the prior knowledge obtained during the active touch learning, the robot took up to 15% fewer decision steps compared to the random method to achieve the same discrimination accuracy in active object discrimination task.

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Temperature dependence of thermal conductivity of biological tissues

Cited by 151 publications

References 25 publications

Integration of extracellular matrix with chitosan adhesive film for sutureless tissue fixation

Integration of extracellular matrix with chitosan adhesive film for sutureless tissue fixation

Coupled electrical-thermal model for monopolar and bipolar radiofrequency liver tumor ablation

Tactile-based active object discrimination and target object search in an unknown workspace

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