Magnetic nanoparticles exposed to alternating magnetic fields have shown a great potential acting as magnetic hyperthermia mediators for cancer treatment. However, a dramatic and unexplained reduction of the nanoparticle magnetic heating efficiency has been evidenced when nanoparticles are located inside cells or tissues. Recent studies suggest the enhancement of nanoparticle clustering and/or immobilization after interaction with cells as possible causes, although a quantitative description of the influence of biological matrices on the magnetic response of magnetic nanoparticles under AC magnetic fields is still lacking. Here, we studied the effect of cell internalization on the dynamical magnetic response of iron oxide nanoparticles (IONPs). AC magnetometry and magnetic susceptibility measurements of two magnetic core sizes (11 and 21 nm) underscored differences in the dynamical magnetic response following cell uptake with effects more pronounced for larger sizes. Two methodologies have been employed for experimentally determining the magnetic heat losses of magnetic nanoparticles inside live cells without risking their viability as well as the suitability of magnetic nanostructures for in vitro hyperthermia studies. Our experimental results-supported by theoretical calculations-reveal that the enhancement of intracellular IONP clustering mainly drives the cell internalization effects rather than intracellular IONP immobilization. Understanding the effects related to the nanoparticle transit into live cells on their magnetic response will allow the design of nanostructures containing magnetic nanoparticles whose dynamical magnetic response will remain invariable in any biological environments, allowing sustained and predictable in vivo heating efficiency.

A complete understanding of domain wall motion in magnetic nanowires is required to enable future nanowire based spintronics devices to work reliably. The production process dictates that the samples are polycrystalline. In this contribution, we present a method to investigate the effects of material grains on domain wall motion using the GPU-based micromagnetic software package MuMax3. We use this method to study current-driven vortex domain wall motion in polycrystalline Permalloy nanowires and find that the influence of material grains is fourfold: an extrinsic pinning at low current densities, an increasing effective damping with disorder strength, shifts in the Walker breakdown current density, and the possibility of the vortex core to switch polarity at grain boundaries. V

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We report an investigation and theoretical assessment of the DC magnetic properties of high-permeability grain-oriented (GO) Fe-Si laminations under variously directed applied fields. We verified that normal magnetization curves, hysteresis loops, and energy losses depend on the field direction according to the sample geometry. This is explainable in terms of specific 180 and 90 domain wall processes and magnetization rotations. We present a novel phenomenological theory of the magnetization curves and hysteresis losses in GO laminations, excited along a generic direction; the theory is based on the single crystal approximation and pre-emptive knowledge of the magnetic behavior of the material along the rolling (RD) and the transverse (TD) directions. This approach is consistent with the general structure of Néel's phase theory, with the additional consideration of hysteresis and losses. Epstein and cross-stacked sheet testing methods are the two base measuring configurations; all the other testing geometries (single sheet, disk, square) are expected to display intermediate behavior. The devised model provides, through a direct procedure, thorough and accurate prediction of magnetization curves and quasi-static losses in these two basic cases. Its application to the other geometries is equally possible, with only a limited amount of supplementary information.