Temperature dependence of catecholamine depletion by reserpine in the heart of the toad (<i>Bufo marinus</i>)

Chang, P.; Rand, M. J.

doi:10.1111/j.1476-5381.1971.tb07121.x

Cited by 3 publications

(1 citation statement)

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“…It has been reported that reserpine, even in high doses, does not cause depletion of catecholamines from tissues of the toad (NAYLER, 1963;BOYD et aI., 1964); however, when the body temperature of the toad is raised, reserpine becomes effective in causing almost complete loss of cardiac catecholamines (CHANG and RAND, 1971).…”

Section: Effects Of Reserpine On Levels Of Catecholamines and Sementioning

confidence: 98%

The Pharmacology of Rauwolfia Alkaloids

Rand¹,

Jurevics²

1977

Antihypertensive Agents

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Section: Effects Of Reserpine On Levels Of Catecholamines and Sementioning

confidence: 98%

The Pharmacology of Rauwolfia Alkaloids

Rand¹,

Jurevics²

1977

Antihypertensive Agents

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Interactive effects of development and hypoxia on catecholamine synthesis and cardiac function in zebrafish (Danio rerio)

2011

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The rate-limiting enzyme in the biosynthetic pathway of catecholamines is tyrosine hydroxylase (TH), the activity of which is dependent on molecular oxygen. Zebrafish (Danio rerio) possess two non-allelic TH coding genes, TH1 and TH2. A principal goal of the present study was to determine if the expression of these genes is sensitive to environmental hypoxia. Additionally, we sought to determine if catecholamine content of larvae was changed by environmental hypoxia, and whether the hearts of hypoxic larvae were equally responsive to exogenous catecholamine (norepinephrine) exposure. After 2 days of exposure to hypoxia [5-7 days post-fertilization (dpf); PO(2) = 30 Torr] TH2 mRNA expression was significantly lower and dopamine β hydroxylase (DβH) mRNA was significantly higher in whole larvae. Whole body catecholamine levels were unchanged until after 4 days of hypoxic exposure (5-9 dpf), at which time there was a significant increase in epinephrine and norepinephrine contents. Norepinephrine content was significantly elevated in the hearts of adult fish after 2 and 4 days of hypoxic exposure, and TH1 mRNA expression was increased in the kidney of both groups. After 2 or 4 days of exposure to hypoxia, larvae displayed significantly lower heart rates than normoxic fish. However, application of exogenous norepinephrine caused similar increases in heart rate in both groups. Overall, it is concluded that the mRNA expression of TH1 and TH2 is differentially affected by hypoxia exposure in larvae and adults. Also, catecholamine biosynthesis appears to be activated by 2 dpf and although whole body catecholamine levels increase during hypoxia (possibly promoting downregulation of cardiac β-adrenergic receptors), there is no accompanying decrease in the response of the heart to adrenergic stimulation.

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Tissue Catecholamines in Rana Tigrina and Effects of Reserpine

Gambhir

Kapoor

Das

1978

Japanese Journal of Pharmacology

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Reserpine depletes tissue catecholamine contents (CAs) in mammals (1, 2) but may (3, 4, 5) or may not (6) affect the CA stores of cold-blooded animals such as the turtle, frog and toad. Doses as high as 50 mg/kg for 3 days failed to decrease toad tissue CAs (6), which were, however, reported to be sensitive to much lower doses if the ambient temperature was high (7). However, no reference to the effect of reserpine in Rana tigrina, the common Indian species, is available.Adult frogs (Rana tigrina) of either sex weighing 100 to 200 g were used. Reserpine was administered in doses of 25 mg/kg/day given i.p. for three days. The control animals were administered 0.65 NaCl (frog saline) solution in proportionate doses. The animals during drug treatment were kept in moist-base cages at an ambient temperature of 32 to 39°C during May and June. The animals were caudally pithed and tissues were removed 24 hr after the last injection. The adrenaline, noradrenaline and dopamine estimations were carried out in peripheral (whole heart) and central (whole brain) tissue using an Aminco-Bowman spectrophoto-fluorometer as described earlier (8).

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Temperature dependence of catecholamine depletion by reserpine in the heart of the toad (Bufo marinus)

Cited by 3 publications

References 12 publications

The Pharmacology of Rauwolfia Alkaloids

The Pharmacology of Rauwolfia Alkaloids

Interactive effects of development and hypoxia on catecholamine synthesis and cardiac function in zebrafish (Danio rerio)

Tissue Catecholamines in Rana Tigrina and Effects of Reserpine

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