Temperature-controlled release by changes in the secondary structure of peptides anchored onto mesoporous silica supports

Abstract

Changes in the conformation of a peptide anchored onto the external surface of mesoporous silica nanoparticles have been used to design novel temperature-controlled delivery systems.

Surface functionalized mesoporous silica nanoparticles as an effective carrier for epirubicin delivery to cancer cells

“…Additionally, controlled release feature can be enabled by using gate keepers, such as antibodies [5], oligonucleotides [6], peptides [7], enzymes [8], dendrimers [9], gold nanoparticles [10], saccharides [11], aptamers [12] and magnetic nanoparticles [13]. The ability of active targeting via different targeting agents such as monoclonal antibody [14], aptamer [15], folic acid [16], peptide [17] as well as passive targeting through EPR effect [18,19] are also well-established on the platform of MSNs.…”

Poly(N-isopropylacrylamide)-gated Fe3O4/SiO2 core shell nanoparticles with expanded mesoporous structures for the temperature triggered release of lysozyme

“…8,9 One of the most appealing features of MSNs that make them highly attractive for delivery is the possibility of functionalizing the external surface of the material with sophisticated molecular, macromolecular or supramolecular ensembles to develop gated MSNs, which are able to demonstrate release in response to specific external stimuli. 10 In this particular field, a number of different gated-MSNs responding to light [11][12][13][14] , pH [15][16][17] , temperature [18][19][20][21] , and certain bio-molecules 22-26 as stimuli have been described.…”

New Oleic Acid‐Capped Mesoporous Silica Particles as Surfactant‐Responsive Delivery Systems

“…The opportunity of functionalizing the external surface of the MSPs with capping agents and uncap them with predefined stimuli makes these supports ideal candidates for controlled delivery applications. A number of examples able to payload deliver in the presence of physical, chemical and biochemical stimuli have been widely described …”

“…Surfactant nature of bile salts from the duodenum has been thoroughly reported in literature. In addition to play an important role in cholesterol elimination route, in hormone secretion or in the stimulation of intestinal immune system, bile contains surfactant molecules that emulsify ingested fats facilitating their intestinal absorption . However, this character of bile salts has not yet been explored as a possible trigger for capped MSPs to deliver certain molecules in the small intestine.…”