Surface functionalized mesoporous silica nanoparticles as an effective carrier for epirubicin delivery to cancer cells

Hanafi‐Bojd, Mohammad Yahya; Jaafari, Mahmoud Reza; Ramezanian, Navid; Xue, Min; Amin, Mohamadreza; Shahtahmassebi, Nasser; Malaekeh‐Nikouei, Bizhan

doi:10.1016/j.ejpb.2014.12.009

Cited by 84 publications

(36 citation statements)

References 60 publications

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“…Amino-propyl groups were subsequently functionalized by carboxyl groups, which led to further reduction in surface area (83 m 2 /g), as well as pore size and lower loading of exenatide shown later in the loading results. Similarly, functionalization with propyl methylphosphonate silane has been reported to reduce the surface area as is seen in the current study [43]. However, PDSNPs still had the highest available surface area among functionalized DSNPs (305 m 2 /g).…”

Section: Resultssupporting

confidence: 74%

Rationally Designed Dendritic Silica Nanoparticles for Oral Delivery of Exenatide

et al. 2019

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Type 2 diabetes makes up approximately 85% of all diabetic cases and it is linked to approximately one-third of all hospitalisations. Newer therapies with long-acting biologics such as glucagon-like peptide-1 (GLP-1) analogues have been promising in managing the disease, but they cannot reverse the pathology of the disease. Additionally, their parenteral administration is often associated with high healthcare costs, risk of infections, and poor patient adherence associated with phobia of needles. Oral delivery of these compounds would significantly improve patient compliance; however, poor enzymatic stability and low permeability across the gastrointestinal tract makes this task challenging. In the present work, large pore dendritic silica nanoparticles (DSNPs) with a pore size of ~10 nm were prepared, functionalized, and optimized in order to achieve high peptide loading and improve intestinal permeation of exenatide, a GLP-1 analogue. Compared to the loading capacity of the most popular, Mobil Composition of Matter No. 41 (MCM-41) with small pores, DSNPs showed significantly high loading owing to their large and dendritic pore structure. Among the tested DSNPs, pristine and phosphonate-modified DSNPs (PDSNPs) displayed remarkable loading of 40 and 35% w/w, respectively. Furthermore, particles successfully coated with positively charged chitosan reduced the burst release of exenatide at both pH 1.2 and 6.8. Compared with free exenatide, both chitosan-coated and uncoated PDSNPs enhanced exenatide transport through the Caco-2 monolayer by 1.7 fold. Interestingly, when a triple co-culture model of intestinal permeation was used, chitosan-coated PDSNPs performed better compared to both PDSNPs and free exenatide, which corroborated our hypothesis behind using chitosan to interact with mucus and improve permeation. These results indicate the emerging role of large pore silica nanoparticles as promising platforms for oral delivery of biologics such as exenatide.

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Section: Resultssupporting

confidence: 74%

Rationally Designed Dendritic Silica Nanoparticles for Oral Delivery of Exenatide

et al. 2019

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“…Fluorescence emission from DOX was measured using a spectrofluorometer at excitation and emission wavelengths of 470/590 nm. The calibration curve was drawn using serial dilutions of DOX in serum and tissue extracts of the control mice [20,21].…”

Section: ▼ Biodistribution Studymentioning

confidence: 99%

The Comparison of Biodistribution, Efficacy and Toxicity of Two PEGylated Liposomal Doxorubicin Formulations in Mice Bearing C-26 Colon Carcinoma: a Preclinical Study

et al. 2016

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“…Nitrogen physisorption measurements (Supplementary Figure S5, Supporting Information) show an overall surface area of 695 m 2 /g, a pore volume of 1.567 cm 3 /g and a pore diameter of 2.79 nm. Although the surface area and the pore volume are low when compared to mesoporous silica nanoparticles without the Fe 3 O 4 core (typically $1000 m 2 /g and 1 cm 3 /g, respectively), these values are reasonable when taking into account the inclusion of an Fe 3 O 4 core [24,45].…”

Section: Characterization Of Fe 3 O 4 Nanoparticles and Mmsnsmentioning

confidence: 97%

Improved anticancer efficacy of epirubicin by magnetic mesoporous silica nanoparticles:in vitroandin vivostudies

Ansari

Jaafari

Bastami

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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The development of magnetic nanoparticles as delivery carriers to magnetically accumulate anticancer drug in cancer tissue has attracted immense interest. In the present study, magnetic mesoporous silica nanoparticles (MMSNs) with magnetite core and silica shell were synthesized. The obtained MMSNs were characterized by DLS, XRD, FT-IR, TEM and VSM in order to investigate the nanoparticle characteristics. With the focus on in vivo validation of such magnetic drug delivery systems, we selected epirubicin (EPI) as the drug. The anticancer properties of EPI-loaded MMSNs were evaluated in a C-26 colon carcinoma model. Alongside monitoring of drug in the tissues with animal imaging system, the tissue distribution was also determined quantitavely. The average size of MMSNs determined with TEM images was about 18.68 ± 2.31 nm. The cellular uptake test indicated that geometric mean fluorescence intensity (MFI) of cells treated with MMSN + EPI in presence of external magnetic field was increasing 27% compared with free EPI. In addition, treatment with drug-loaded MMSNs with the aid of external magnetic gradient had significantly higher inhibition efficacy towards tumor growth than the free EPI treated mice. The targeted drug delivery through external magnet-attraction using EPI-loaded MMSNs resulted in high tumor cell uptake, which leads to elimination of cancer cells effectively.

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Surface functionalized mesoporous silica nanoparticles as an effective carrier for epirubicin delivery to cancer cells

Cited by 84 publications

References 60 publications

Rationally Designed Dendritic Silica Nanoparticles for Oral Delivery of Exenatide

Rationally Designed Dendritic Silica Nanoparticles for Oral Delivery of Exenatide

The Comparison of Biodistribution, Efficacy and Toxicity of Two PEGylated Liposomal Doxorubicin Formulations in Mice Bearing C-26 Colon Carcinoma: a Preclinical Study

Improved anticancer efficacy of epirubicin by magnetic mesoporous silica nanoparticles:in vitroandin vivostudies

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