“…They are associated with development and severity of allergic asthma and atopic dermatitis 5–17 . HDM sensitization rates in asthmatic individuals rise up to 80%, and high exposure can induce bronchial symptoms in non‐sensitized asthmatics while avoidance can improve clinical symptoms and inflammation 7,9,18–21 …”
Section: Introductionmentioning
confidence: 99%
“…[5][6][7][8][9][10][11][12][13][14][15][16][17] HDM sensitization rates in asthmatic individuals rise up to 80%, and high exposure can induce bronchial symptoms in non-sensitized asthmatics while avoidance can improve clinical symptoms and inflammation. 7,9,[18][19][20][21] Mechanisms by which HDM allergens can elicit allergic reactions and inflammation or even promote sensitization to other allergens include disruption of epithelial tight-junctions, activation of the innate and adaptive immune system, and promotion of a shift towards Th2-responses. Therefore, they are considered a crucial factor in the atopic march.…”
Background: House dust mites (HDM) are among the most important sources for airborne allergens with high relevance for atopic diseases. Routine tests contain only 4 of 32 registered allergens of Dermatophagoides pteronyssinus. Clinical relevance and pathomechanistic properties of many allergens are not well understood.Objective: The association of several HDM allergens with allergic rhinitis, allergic asthma, and atopic dermatitis was investigated to identify allergens with biomarker potential and to transfer them into diagnostics.
“…They are associated with development and severity of allergic asthma and atopic dermatitis 5–17 . HDM sensitization rates in asthmatic individuals rise up to 80%, and high exposure can induce bronchial symptoms in non‐sensitized asthmatics while avoidance can improve clinical symptoms and inflammation 7,9,18–21 …”
Section: Introductionmentioning
confidence: 99%
“…[5][6][7][8][9][10][11][12][13][14][15][16][17] HDM sensitization rates in asthmatic individuals rise up to 80%, and high exposure can induce bronchial symptoms in non-sensitized asthmatics while avoidance can improve clinical symptoms and inflammation. 7,9,[18][19][20][21] Mechanisms by which HDM allergens can elicit allergic reactions and inflammation or even promote sensitization to other allergens include disruption of epithelial tight-junctions, activation of the innate and adaptive immune system, and promotion of a shift towards Th2-responses. Therefore, they are considered a crucial factor in the atopic march.…”
Background: House dust mites (HDM) are among the most important sources for airborne allergens with high relevance for atopic diseases. Routine tests contain only 4 of 32 registered allergens of Dermatophagoides pteronyssinus. Clinical relevance and pathomechanistic properties of many allergens are not well understood.Objective: The association of several HDM allergens with allergic rhinitis, allergic asthma, and atopic dermatitis was investigated to identify allergens with biomarker potential and to transfer them into diagnostics.
“…Für das Asthma gibt es eine weitere, etablierte Methode zur Allergenreduktion Allergenreduktion , bei der über ein Gerät ein kontinuierlicher Luftstrom („temperature controlled laminar airflow“ [TLA]) induziert wird, der zu einer Reduktion der Allergenkonzentration während der Nacht führt. In einer kleineren Proof-of-concept-Studie mit 10 AD-Patienten konnte kürzlich eine Reduktion der Schwere der AD, insbesondere im Kopf‑/Halsbereich, nach 3 Monaten erzielt werden [ 12 ].…”
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