Specific <scp>IgE</scp> against the house dust mite allergens Der p 5, 20 and 21 influences the phenotype and severity of atopic diseases

Walsemann, Theresa; Böttger, Marisa; Traidl, Stephan; Schwager, Christian; Gülşen, Aşkın; Freimooser, Sina; Roesner, Lennart M.; Werfel, Thomas; Jappe, Uta

doi:10.1111/all.15553

Cited by 11 publications

(16 citation statements)

References 80 publications

(150 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, testing solely for these components would miss sensitization in 2.70% (only sensitized to Der p 5, Der p 7, Der p 21) and overlook 37.21% sensitized to them in addition to major allergens. Recognizing mid‐tier/minor components like Der p 5, Der p 7, Der p 21 is crucial for accurate diagnosis, considering their unique immunological properties 20–22 . As previously described by Posa et al 8 .…”

Section: Discussionmentioning

confidence: 98%

Sensitization profiles to house dust mite Dermatophagoides pteronyssinus molecular allergens in the Lithuanian population: Understanding allergic sensitization patterns

Biliute,

Miskinyte,

Miskiniene

et al. 2024

Clinical & Translational All

View full text Add to dashboard Cite

BackgroundHouse dust mite (HDM) allergy is a prevalent global health concern, with varying sensitization profiles observed across populations. We aimed to provide a comprehensive assessment of molecular allergen sensitization patterns in the Lithuanian population, with a focus on Dermatophagoides pteronyssinus (Der p), and investigate patterns of concomitant reactivity among different allergens to enhance the accuracy of HDM allergy diagnostics.MethodsA comprehensive analysis of 1520 patient test results in Lithuania from 2020 to 2022 was performed. Sensitization patterns to major (Der p 1, Der p 2, and Der p 23) and minor (Der p 5, Der p 7, and Der p 21) Der p allergen components were described using molecular‐based diagnostics. Additionally, we investigated sensitization to allergen components from other allergen sources, including tropomyosins (Der p 10, Per a 7, Pen m 1, Ani s 3, Blo t 10) and arginine kinases (Pen m 2, Bla g 9, Der p 20).ResultsThis study reveals a high prevalence of HDM sensitization in Lithuania ‐ 481 individuals (45.38% of the sensitized group) exhibited sensitization to at least one Der p allergen component. Importantly, within the sensitized group, 37.21% of patients were sensitized to Der p 5, Der p 7, or Der p 21 in addition to major allergenic components. Distinct sensitization patterns were observed across different age groups, indicating the influence of age‐related factors. Furthermore, we confirmed cross‐reactivity between Der p 5 and Blo t 5 as well as between Der p 21 and Blo t 21, emphasizing the clinical relevance of these associations. We also highlighted the complexity of sensitization patterns among tropomyosins and arginine kinases.ConclusionThis study provides valuable insights into HDM allergy sensitization profiles in Lithuania, emphasizing the importance of considering major and minor HDM allergen components for accurate diagnosis and management of HDM‐related allergic diseases. Differences between populations and age‐related factors impact sensitization patterns. Understanding concomitant reactivity among allergens, such as Der p 5 and Blo t 5, Der p 21 and Blo t 21, tropomyosins, and arginine kinases, is crucial for improving diagnostic strategies and developing targeted interventions for allergic individuals.

show abstract

Section: Discussionmentioning

confidence: 98%

Sensitization profiles to house dust mite Dermatophagoides pteronyssinus molecular allergens in the Lithuanian population: Understanding allergic sensitization patterns

Biliute,

Miskinyte,

Miskiniene

et al. 2024

Clinical & Translational All

View full text Add to dashboard Cite

show abstract

“…22,23 However, our study did not yield distinct sensitization profiles associated with specific diseases, underscoring the potential influence of geographic and demographic factors on sensitization patterns. 4,24 One particularly intriguing observation was the progressive increase in the number of sensitized mite allergen molecules, concurrently with increased sensitization to other aeroallergens as age advanced. Notably, the substantial degree of selective tropomyosin and arginine kinase sensitization suggests that the primary source of sensitization likely extends beyond mite exposure.…”

Section: Discussionmentioning

confidence: 99%

Mite allergen sensitization patterns in Turkish children: Age‐related changes and molecular correlations

Tuten Dal,

Sahiner,

Soyer

et al. 2024

Pediatric Allergy Immunology

View full text Add to dashboard Cite

BackgroundMites are ubiquitous aeroallergens found worldwide. Elucidating individual mite allergen sensitization patterns provides critical insights for managing allergic diseases. This study aimed to investigate molecular allergen (MA) sensitization patterns across different age groups and explore cluster relationships among mite‐sensitized children.MethodsWe analyzed 76 children who exhibited sensitization to at least one of the 17 distinct mite MAs through microarray testing.ResultsDermatophagoides farinae exhibited a slightly higher prevalence of sensitization compared with Dermatophagoides pteronyssinus. Der p 1/2 and Der f 1/2 demonstrated an almost 40% sensitization rate, while Der p 10/Blo t 10, Der p 20, Der p 23, and Gly d 2/Lep d 2 displayed an approximately 20% sensitization rate. Sensitization levels and ratios increased significantly with age for Der p 23 but showed numerical rises for other MAs, except for Der p 10/Blo t 10. The presence of various types of atopic diseases had only a minimal impact on sensitization profiles. Strong correlations emerged between Der f 2 and Der p 2, Der p 10 and Blo t 10, Der p 21 and Blo t 5, as well as Gly d 2 and Lep d 2. Hierarchical cluster analysis substantiated these relationships. Der p 10 and its homolog Blo t 10‐sensitive patients (15/76) were mostly seen as mono sensitization(12/15). Ten patients exhibited monosensitization to Der p 20, suggesting a possible association with scabies infection.ConclusionIn children, mite sensitization diversity and levels increased with age. The presence of significant correlations/cluster relationships among these sensitizations underscores homologies among specific MAs.

show abstract

“…Clinically related to asthma, Der p 23 sensitization had a high prevalence in HDM-sensitive people and was discovered in recent years ( 9 , 22 , 42 ). Walsemann and colleagues have shown that Der p 21 sIgE can affect the development of AD ( 43 ). In our study, the Der p 21 sIgE positive rate in the non-AD group was higher than in the AD group ( Figure 6D ), with the same trend for Der p 2 and Der f 2, indicating that Der p 21, Der p 2, and Der f 2 might play a more important role in respiratory allergic disease.…”

Section: Discussionmentioning

confidence: 99%

Serological analysis of allergic components of house dust mite provides more insight in epidemiological characteristics and clinical symptom development in North China

Liu

Zhao

Wang³

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

BackgroundHouse dust mite (HDM) is the most common airborne source causing complex allergy symptoms. There are geographic differences in the allergen molecule sensitization profiles. Serological testing with allergen components may provide more clues for diagnosis and clinical management.ObjectiveThis study aims to investigate the sensitization profile of eight HDM allergen components in a large number of patients enrolled in the clinic and to analyze the relation of gender, age, and clinical symptoms in North China.MethodsThe 548 serum samples of HDM-allergic patients (ImmunoCAP® d1 or d2 IgE ≥0.35) were collected in Beijing City and divided in four different age groups and three allergic symptoms. The specific IgE of HDM allergenic components, Der p 1/Der f 1, Der p 2/Der f 2, Der p 7, Der p 10, Der p 21, and Der p 23, was measured using the micro-arrayed allergen test kit developed by Hangzhou Zheda Dixun Biological Gene Engineering Co., Ltd. The new system was validated by comparing to single-component Der p 1, Der p 2, and Der p 23 tests by ImmunoCAP in 39 sera. The epidemiological study of these IgE profiles and the relation to age and clinical phenotypes were analyzed.ResultsA greater proportion of male patients was in the younger age groups, while more female patients were in the adult groups. Both the sIgE levels and the positive rates (approximately 60%) against Der p 1/Der f 1 and Der p 2/Der f 2 were higher than for the Der p 7, Der p 10, and Der p 21 components (below 25%). The Der f 1 and Der p 2 positive rates were higher in 2–12-year-old children. The Der p 2 and Der f 2 IgE levels and positive rates were higher in the allergic rhinitis group. The positive rates of Der p 10 increased significantly with age. Der p 21 is relevant in allergic dermatitis symptom, while Der p 23 contributes to asthma development.ConclusionHDM groups 1 and 2 were the major sensitizing allergens, with group 2 being the most important component relevant to respiratory symptoms in North China. The Der p 10 sensitization tends to increase with age. Der p 21 and Der p 23 might be associated with the development of allergic skin disease and asthma, respectively. Multiple allergen sensitizations increased the risk of allergic asthma.

show abstract

Specific IgE against the house dust mite allergens Der p 5, 20 and 21 influences the phenotype and severity of atopic diseases

Cited by 11 publications

References 80 publications

Sensitization profiles to house dust mite Dermatophagoides pteronyssinus molecular allergens in the Lithuanian population: Understanding allergic sensitization patterns

Sensitization profiles to house dust mite Dermatophagoides pteronyssinus molecular allergens in the Lithuanian population: Understanding allergic sensitization patterns

Mite allergen sensitization patterns in Turkish children: Age‐related changes and molecular correlations

Serological analysis of allergic components of house dust mite provides more insight in epidemiological characteristics and clinical symptom development in North China

Contact Info

Product

Resources

About