Temperature- and pH-responsive nanoparticles of biocompatible polyurethanes for doxorubicin delivery

Wang, Anning; Gao, Hui; Sun, Yanfang; Sun, Yulong; Yang, Ying‐Wei; Wu, Guolin; Wang, Yinong; Fan, Yunge; Ma, Jianbiao

doi:10.1016/j.ijpharm.2012.12.021

Cited by 83 publications

(30 citation statements)

References 35 publications

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“…Also, these analyses are utilized in order to understand the environmentally responsive mechanism at different temperatures. 166,173,180,183–185 The visible peaks of NMR spectroscopy and their movement in respect of temperature changes, indicating the thermal-responsive behavior of NPs such as breakdown of polymer–water hydrogen bonding (water solubility of the polymers). 183 …”

Section: Characterization Of Thermosensitive Npsmentioning

confidence: 99%

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Karimi

Zangabad

Ghasemi

et al. 2016

ACS Appl. Mater. Interfaces

345

212

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Smart drug delivery systems (DDSs) have attracted the attention of many scientists, as carriers that can be stimulated by changes in environmental parameters such as temperature, pH, light, electromagnetic fields, mechanical forces, etc. These smart nanocarriers can release their cargo on demand when their target is reached and the stimulus is applied. Using the techniques of nanotechnology, these nanocarriers can be tailored to be target-specific, and exhibit delayed or controlled release of drugs. Temperature-responsive nanocarriers are one of most important groups of smart nanoparticles (NPs) that have been investigated during the past decades. Temperature can either act as an external stimulus when heat is applied from the outside, or can be internal when pathological lesions have a naturally elevated termperature. A low critical solution temperature (LCST) is a special feature of some polymeric materials, and most of the temperature-responsive nanocarriers have been designed based on this feature. In this review, we attempt to summarize recent efforts to prepare innovative temperature-responsive nanocarriers and discuss their novel applications.

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Section: Characterization Of Thermosensitive Npsmentioning

confidence: 99%

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Karimi

Zangabad

Ghasemi

et al. 2016

ACS Appl. Mater. Interfaces

345

212

View full text Add to dashboard Cite

show abstract

“…15, 16 Furthermore, therapeutic nanoparticles have been developed that respond to two or more of these stimuli. 17–24 In one example, Li and coworkers reported the development of doxorubicin loaded polymer nanoparticles and polymersomes, composed of a block copolymer containing segments of poly(ethylene oxide) and poly( trans - N -(2-ethoxy-1,3-dioxan-5-yl) acrylamide), which assemble at physiological temperatures and disassemble in acidic conditions. 23 Such acid-sensitive nanoparticles may be useful for applications in intracellular drug delivery due to acidic conditions found in endosomes and lysosomes.…”

Section: Introductionmentioning

confidence: 99%

Dual pH- and temperature-responsive protein nanoparticles

Matsumoto

Buchman²,

Rome

et al. 2015

European Polymer Journal

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Multiply responsive protein nanoparticles are interesting for a variety of applications. Herein, we describe the synthesis of a vault nanoparticle that responds to both temperature and pH. Specifically, poly(N-isopropylacrylamide-co-acrylic acid) with a pyridyl disulfide end group was prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization. The polymer had a lower critical solution temperature (LCST) of 31.9 °C at pH 5, 44.0 °C at pH 6 and above 60 °C at pH 7. The polymer was conjugated to human major vault protein (hMVP), and the resulting nanoparticle was analyzed by UV-Vis, dynamic light scattering (DLS) and electron microscopy. The data demonstrated that poly(N-isopropylacrylamide-co-acrylic acid)-vault conjugate did not respond to temperatures below 60 °C at pH 7, while the nanoparticles reversibly aggregated at pH 6. Furthermore, it was shown that the vault nanoparticle structure remained intact for at least three heat and cooling cycles. Thus, these dually responsive nanoparticles may serve as a platform for drug delivery and other applications.

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“…As shown in Table 2, the molecular weight of PUcs increases with increase in curcumin content. Which offers appropriate mechanical properties for biomedical application [47].…”

Section: Resultsmentioning

confidence: 99%

Synthesis and characterization of curcumin segmented polyurethane with induced antiplatelet activity

et al. 2015

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The main goal of this study is the synthesis of hemocompatible polyurethane elastomer containing curcumin by the reaction of poly(ξ-caprolactone) (PCL), and 1,6-hexamethylene diisocyanate (HDI), which was chain extended with varying molar ratios of 1,4-butandiol (BDO), and curcumin. Molecular structure of the synthesized polyurethane was confirmed using FT-IR and 1 HNMR spectroscopy techniques. The effect of curcumin on characteristics of the synthesized polymers was analyzed by gel permeation chromatography (GPC), differential scanning calorimetry (DSC), tensile testing, and also water contact angle measurement (WCA). The influence of curcumin on antiplatelet behavior of the curcumin extended elastomer was confirmed by static platelet adhesion (SPA) test and the number of the adhered platelets was determined using the lactate dehydrogenase (LDH) assay, in comparison with the polymer extended solely with BDO. Thermal and mechanical properties as well as hydrophobicity are enhanced through increasing curcumin content. Overall, improvement in mentioned properties led to enhanced antiplatelet behavior of curcumin containing segmented PU elastomers (PUcs).

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Temperature- and pH-responsive nanoparticles of biocompatible polyurethanes for doxorubicin delivery

Cited by 83 publications

References 35 publications

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Temperature-Responsive Smart Nanocarriers for Delivery Of Therapeutic Agents: Applications and Recent Advances

Dual pH- and temperature-responsive protein nanoparticles

Synthesis and characterization of curcumin segmented polyurethane with induced antiplatelet activity

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