2019
DOI: 10.1038/s41467-019-11136-6
|View full text |Cite
|
Sign up to set email alerts
|

Temperature and insulin signaling regulate body size in Hydra by the Wnt and TGF-beta pathways

Abstract: How multicellular organisms assess and control their size is a fundamental question in biology, yet the molecular and genetic mechanisms that control organ or organism size remain largely unsolved. The freshwater polyp Hydra demonstrates a high capacity to adapt its body size to different temperatures. Here we identify the molecular mechanisms controlling this phenotypic plasticity and show that temperature-induced cell number changes are controlled by Wnt- and TGF-β signaling. Further w… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

3
35
0

Year Published

2019
2019
2023
2023

Publication Types

Select...
5
1
1

Relationship

1
6

Authors

Journals

citations
Cited by 30 publications
(38 citation statements)
references
References 76 publications
(105 reference statements)
3
35
0
Order By: Relevance
“…Animals reared at 18°C formed ~40% more ectopic tentacles than animals reared at 12°C (Figure 1B), indicating that temperature modulates Wnt-signaling and thus plays a role in controlling axis formation and maintenance of the proliferation zone in Hydra. These data are in agreement with earlier observations 50 . In order to proof that temperature is interfering with the Wnt-signaling pathway, we reared transgenic animals, carrying a constitutively active β -catenin overexpression (OE) 37 construct at 12°C and 18°C.…”
Section: Temperature and Bacteria Modulate Beta-catenin Activitysupporting
confidence: 94%
See 3 more Smart Citations
“…Animals reared at 18°C formed ~40% more ectopic tentacles than animals reared at 12°C (Figure 1B), indicating that temperature modulates Wnt-signaling and thus plays a role in controlling axis formation and maintenance of the proliferation zone in Hydra. These data are in agreement with earlier observations 50 . In order to proof that temperature is interfering with the Wnt-signaling pathway, we reared transgenic animals, carrying a constitutively active β -catenin overexpression (OE) 37 construct at 12°C and 18°C.…”
Section: Temperature and Bacteria Modulate Beta-catenin Activitysupporting
confidence: 94%
“…To investigate whether temperature interferes with the Wnt-dependent developmental program in Hydra we cultured polyps at 12 °C and 18 °C and treated the animals with Alsterpaullone (ALP) (Figure 1A). ALP is an inhibitor for GSK3-β and causes an activation of the Wnt-signaling pathway 42,50,51 .…”
Section: Temperature and Bacteria Modulate Beta-catenin Activitymentioning
confidence: 99%
See 2 more Smart Citations
“…The clonal culture of healthy H. oligactis demonstrates a very low interindividual variation, evident in minimal deviations in the number of tentacles ( Fig 3J), bud detachment time ( Fig 3L), mesoglea thickness (S5A Fig) and number of epithelial cells (S5B Fig). This is not surprising, since the number of tentacles and pattern of their emergence as well as the number of cells per polyp are species-specific traits and are genetically controlled [25][26][27]. In tumorous polyps, interindividual variation is markedly higher compared to the healthy polyps.…”
Section: Spirochetes Cause Developmental Alterations and Fitness Lossmentioning
confidence: 99%