2020
DOI: 10.1371/journal.ppat.1008375
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Abstract: The extent to which disturbances in the resident microbiota can compromise an animal's health is poorly understood. Hydra is one of the evolutionary oldest animals with naturally occurring tumors. Here, we found a causal relationship between an environmental spirochete (Turneriella spec.) and tumorigenesis in Hydra. Unexpectedly, virulence of this pathogen requires the presence of Pseudomonas spec., a member of Hydra´s beneficial microbiome indicating that dynamic interactions between a resident bacterium and … Show more

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Cited by 25 publications
(26 citation statements)
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“…It forms a causal relationship between an environmental spirochete (Turneriella spec.) [29]. Similar hydra metalloproteinase, HMP1, and odocoryne metalloproteinase 1 (PMP1) have been also isolated from jellyfish and sea anemone toxins [30] (table 3).…”
Section: Hydra Toxinsmentioning
confidence: 90%
“…It forms a causal relationship between an environmental spirochete (Turneriella spec.) [29]. Similar hydra metalloproteinase, HMP1, and odocoryne metalloproteinase 1 (PMP1) have been also isolated from jellyfish and sea anemone toxins [30] (table 3).…”
Section: Hydra Toxinsmentioning
confidence: 90%
“…The predominance of Proteobacteria has also been reported in the microbiota of another planarian species called Dugesia japonica 57 , as well as in the fruit fly, Drosophila. melanogaster 58 , and Hydra oligactis 59 . Notably, Firmicutes are also the predominant phyla for C. elegans .…”
Section: Discussionmentioning
confidence: 99%
“…The microbial organisms that animals coexist with [collectively known as the host associated microbiota ( Berg et al, 2020 )] have an increasingly recognized effect on their host ( McFall-Ngai et al, 2013 ). The microbiota often influences host health ( Shreiner et al, 2015 ; Rathje et al, 2020 ), behavior ( Murillo-Rincon et al, 2017 ; Vuong et al, 2017 ), and in some cases it was shown to affect fitness-determining traits of the host, such as its growth rate, reproduction, survival and aging ( Shin et al, 2011 ; Sison-Mangus et al, 2015 ; Gould et al, 2018 ; Popkes and Valenzano, 2020 ).…”
Section: Introductionmentioning
confidence: 99%
“…The freshwater cnidarian Hydra coexists with a rich diversity of host-associated microbes. These microbes colonize external epithelial surfaces ( Fraune et al, 2015 ; Deines and Bosch, 2016 ), inhabit intercellular spaces ( Rathje et al, 2020 ), and in some species can even occur inside cells as endosymbionts ( Fraune and Bosch, 2007 ). The Hydra microbiota has diverse effects on the host.…”
Section: Introductionmentioning
confidence: 99%