Dynamic interactions within the host-associated microbiota cause tumor formation in the basal metazoan Hydra

Rathje, Kai; Mortzfeld, Benedikt M; Hoeppner, Marc P.; Taubenheim, Jan; Bosch, Thomas C. G.; Klimovich, Alexander

doi:10.1371/journal.ppat.1008375

Cited by 28 publications

(32 citation statements)

References 86 publications

(112 reference statements)

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“…The microbial organisms that animals coexist with [collectively known as the host associated microbiota ( Berg et al, 2020 )] have an increasingly recognized effect on their host ( McFall-Ngai et al, 2013 ). The microbiota often influences host health ( Shreiner et al, 2015 ; Rathje et al, 2020 ), behavior ( Murillo-Rincon et al, 2017 ; Vuong et al, 2017 ), and in some cases it was shown to affect fitness-determining traits of the host, such as its growth rate, reproduction, survival and aging ( Shin et al, 2011 ; Sison-Mangus et al, 2015 ; Gould et al, 2018 ; Popkes and Valenzano, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

“…The freshwater cnidarian Hydra coexists with a rich diversity of host-associated microbes. These microbes colonize external epithelial surfaces ( Fraune et al, 2015 ; Deines and Bosch, 2016 ), inhabit intercellular spaces ( Rathje et al, 2020 ), and in some species can even occur inside cells as endosymbionts ( Fraune and Bosch, 2007 ). The Hydra microbiota has diverse effects on the host.…”

Section: Introductionmentioning

confidence: 99%

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Population Differences and Host Species Predict Variation in the Diversity of Host-Associated Microbes in Hydra

et al. 2022

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Most animals co-exist with diverse host-associated microbial organisms that often form complex communities varying between individuals, habitats, species and higher taxonomic levels. Factors driving variation in the diversity of host-associated microbes are complex and still poorly understood. Here, we describe the bacterial composition of field-collected Hydra, a freshwater cnidarian that forms stable associations with microbial species in the laboratory and displays complex interactions with components of the microbiota. We sampled Hydra polyps from 21 Central European water bodies and identified bacterial taxa through 16S rRNA sequencing. We asked whether diversity and taxonomic composition of host-associated bacteria depends on sampling location, habitat type, host species or host reproductive mode (sexual vs. asexual). Bacterial diversity was most strongly explained by sampling location, suggesting that the source environment plays an important role in the assembly of bacterial communities associated with Hydra polyps. We also found significant differences between host species in their bacterial composition that partly mirrored variations observed in lab strains. Furthermore, we detected a minor effect of host reproductive mode on bacterial diversity. Overall, our results suggest that extrinsic (habitat identity) factors predict the diversity of host-associated bacterial communities more strongly than intrinsic (species identity) factors, however, only a combination of both factors determines microbiota composition in Hydra.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Population Differences and Host Species Predict Variation in the Diversity of Host-Associated Microbes in Hydra

et al. 2022

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“…It forms a causal relationship between an environmental spirochete (Turneriella spec.) [29]. Similar hydra metalloproteinase, HMP1, and odocoryne metalloproteinase 1 (PMP1) have been also isolated from jellyfish and sea anemone toxins [30] (table 3).…”

Section: Hydra Toxinsmentioning

confidence: 90%

Coelenterate Toxins, Its Pharmaceutical and Therapeutic Effects

Sharma

Upadhyay

2021

Int J Curr Pharm Sci

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Present review article emphasizes species specific coelenterate toxins, its pharmaceutical and therapeutic effects. Most of the coelenterates inflict venom accidently by using nematocysts found on arms. These animals very quickly do massive and multiple inflictions of venom which causes cardiotoxicity that leads to the death of human beings. Coelenterate venom toxin groups differ in their composition and show diverse biological activity i.e. cytolytic or neurotoxic, hemolytic, anti-parasitic activity, α-amylase inhibitor activity, and analgesic activity anti-cancerous and antitumor activity, anti-inflammatory and antimicrobial activity. Coelenterate venom initiates toxic and immunological reactions exert their effects by modifying the properties of the ion channels involved in action potential generation in nerve, heart, and skeletal muscles. This article suggests available information, on coelenterate toxins could be used to develop potential therapeutic interventions for various human diseases and disorders.

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“…The predominance of Proteobacteria has also been reported in the microbiota of another planarian species called Dugesia japonica 57 , as well as in the fruit fly, Drosophila. melanogaster 58 , and Hydra oligactis 59 . Notably, Firmicutes are also the predominant phyla for C. elegans .…”

Section: Discussionmentioning

confidence: 99%

Culturomics revealed the bacterial constituents of the microbiota of a 10-year-old laboratory culture of planarian species S. mediterranea

Kangale

Raoult

Fournier

et al. 2021

Sci Rep

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The planarian species Schmidtea mediterranea is a flatworm living in freshwater that is used in the research laboratory as a model to study developmental and regeneration mechanisms, as well as antibacterial mechanisms. However, the cultivable microbial repertoire of the microbes comprising its microbiota remains unknown. Here, we characterized the bacterial constituents of a 10-year-old laboratory culture of planarian species S. mediterranea via culturomics analysis. We isolated 40 cultivable bacterial species, including 1 unidentifiable species. The predominant phylum is Proteobacteria, and the most common genus is Pseudomonas. We discovered that parts of the bacterial flora of the planarian S. mediterranea can be classified as fish pathogens and opportunistic human pathogens.

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Dynamic interactions within the host-associated microbiota cause tumor formation in the basal metazoan Hydra

Cited by 28 publications

References 86 publications

Population Differences and Host Species Predict Variation in the Diversity of Host-Associated Microbes in Hydra

Population Differences and Host Species Predict Variation in the Diversity of Host-Associated Microbes in Hydra

Coelenterate Toxins, Its Pharmaceutical and Therapeutic Effects

Culturomics revealed the bacterial constituents of the microbiota of a 10-year-old laboratory culture of planarian species S. mediterranea

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