Temozolomide and oral etoposide in children with recurrent malignant brain tumors

Ruggiero, Antonio; Ariano, Anna; Triarico, Silvia; Capozza, Michele Antonio; Romano, Alberto; Maurizi, Palma; Attinà, Giorgio

doi:10.7573/dic.2020-3-1

Cited by 7 publications

(5 citation statements)

References 88 publications

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“…Several chemotherapy agents have been used for DMGs, including temozolomide, and etoposide [99][100][101]. Temozolomide is an alkylating agent that works by damaging DNA and preventing tumor cells from dividing.…”

Section: Treatment Options 81 Chemotherapymentioning

confidence: 99%

Decoding Diffuse Midline Gliomas: A Comprehensive Review of Pathogenesis, Diagnosis and Treatment

Al Sharie,

Abu Laban,

Al-Hussaini

2023

Cancers

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Diffuse midline gliomas (DMGs) are a group of aggressive CNS tumors, primarily affecting children and young adults, which have historically been associated with dismal outcomes. As the name implies, they arise in midline structures in the CNS, primarily in the thalamus, brainstem, and spinal cord. In more recent years, significant advances have been made in our understanding of DMGs, including molecular features, with the identification of potential therapeutic targets. We aim to provide an overview of the most recent updates in the field of DMGs, including classification, molecular subtypes, diagnostic techniques, and emerging therapeutic strategies including a review of the ongoing clinical trials, thus providing the treating multidisciplinary team with a comprehensive understanding of the current landscape and potential therapeutic strategies for this devastating group of tumors.

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Section: Treatment Options 81 Chemotherapymentioning

confidence: 99%

Decoding Diffuse Midline Gliomas: A Comprehensive Review of Pathogenesis, Diagnosis and Treatment

Al Sharie,

Abu Laban,

Al-Hussaini

2023

Cancers

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“…Etoposide (VP-16, epipodophyllotoxin) is an anticancer drug derived semi-synthetically from a non-alkaloid lignan, podophyllotoxin sourced from the rhizomes and dried roots of Podophyllum emodi or Podophyllum peltatum ( Kluska and Woźniak, 2021 ). Etoposide has been widely employed in cancer chemotherapy to combat various types of cancer such as adrenocortical carcinoma ( Paragliola et al, 2020 ), brain tumors ( Ruggiero et al, 2020 ), breast cancer ( Atienza et al, 1995 ), leukemia ( Economides et al, 2019 ), testicular carcinoma ( Alsdorf et al, 2019 ) and small cell lung carcinoma ( Noronha et al, 2020 ).…”

Section: Semi-synthetic Studies For New Drugs Derived From Natural Co...mentioning

confidence: 99%

The use of African medicinal plants in cancer management

Gaobotse

Venkataraman²,

Brown³

et al. 2023

Front. Pharmacol.

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Cancer is the third leading cause of premature death in sub-Saharan Africa. Cervical cancer has the highest number of incidences in sub-Saharan Africa due to high HIV prevalence (70% of global cases) in African countries which is linked to increasing the risk of developing cervical cancer, and the continuous high risk of being infected with Human papillomavirus In 2020, the risk of dying from cancer amongst women was higher in Eastern Africa (11%) than it was in Northern America (7.4%). Plants continue to provide unlimited pharmacological bioactive compounds that are used to manage various illnesses, including cancer. By reviewing the literature, we provide an inventory of African plants with reported anticancer activity and evidence supporting their use in cancer management. In this review, we report 23 plants that have been used for cancer management in Africa, where the anticancer extracts are usually prepared from barks, fruits, leaves, roots, and stems of these plants. Extensive information is reported about the bioactive compounds present in these plants as well as their potential activities against various forms of cancer. However, information on the anticancer properties of other African medicinal plants is insufficient. Therefore, there is a need to isolate and evaluate the anticancer potential of bioactive compounds from other African medicinal plants. Further studies on these plants will allow the elucidation of their anticancer mechanisms of action and allow the identification of phytochemicals that are responsible for their anticancer properties. Overall, this review provides consolidated and extensive information not only on diverse medicinal plants of Africa but on the different types of cancer that these plants are used to manage and the diverse mechanisms and pathways that are involved during cancer alleviation.

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“…Etoposide has been adopted also for the management of hemophagocytic lymphohistiocytosis during pregnancy, a rare and severe syndrome that requires the adoption of etoposide for the cases refractory to corticosteroids [128]. However, further studies are required to identify its appropriate dosage and the correlation between dose and side effects (such as myelosuppression) on the fetus [129].…”

Section: Topoisomerase II Inhibitors: Etoposidementioning

confidence: 99%

Transplacental Passage and Fetal Effects of Antineoplastic Treatment during Pregnancy

Triarico

Rivetti

Capozza³

et al. 2022

Cancers

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The incidence of PAC is relatively infrequent among pregnant women. However, it has gradually increased in recent years, becoming a challenging area for clinicians that should take into account in the same way maternal benefits and fetal potential risks correlated to the antineoplastic treatment. None of the antineoplastic drugs is completely risk-free during the pregnancy, the timing of exposure and transplacental transfer properties influence the toxicity of the fetus. Despite the lack of guidelines about the management of PAC, several studies have described the use and the potential fetal and neonatal adverse events of antineoplastic drugs during pregnancy. We provide a review of the available literature about the transplacental passage and fetal effects of chemotherapy and targeted agents, to guide the clinicians in the most appropriate choices for the management of PAC.

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Temozolomide and oral etoposide in children with recurrent malignant brain tumors

Cited by 7 publications

References 88 publications

Decoding Diffuse Midline Gliomas: A Comprehensive Review of Pathogenesis, Diagnosis and Treatment

Decoding Diffuse Midline Gliomas: A Comprehensive Review of Pathogenesis, Diagnosis and Treatment

The use of African medicinal plants in cancer management

Transplacental Passage and Fetal Effects of Antineoplastic Treatment during Pregnancy

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