The use of African medicinal plants in cancer management

Abstract

Cancer is the third leading cause of premature death in sub-Saharan Africa. Cervical cancer has the highest number of incidences in sub-Saharan Africa due to high HIV prevalence (70% of global cases) in African countries which is linked to increasing the risk of developing cervical cancer, and the continuous high risk of being infected with Human papillomavirus In 2020, the risk of dying from cancer amongst women was higher in Eastern Africa (11%) than it was in Northern America (7.4%). Plants continue to provide unlimited pharmacological bioactive compounds that are used to manage various illnesses, including cancer. By reviewing the literature, we provide an inventory of African plants with reported anticancer activity and evidence supporting their use in cancer management. In this review, we report 23 plants that have been used for cancer management in Africa, where the anticancer extracts are usually prepared from barks, fruits, leaves, roots, and stems of these plants. Extensive information is reported about the bioactive compounds present in these plants as well as their potential activities against various forms of cancer. However, information on the anticancer properties of other African medicinal plants is insufficient. Therefore, there is a need to isolate and evaluate the anticancer potential of bioactive compounds from other African medicinal plants. Further studies on these plants will allow the elucidation of their anticancer mechanisms of action and allow the identification of phytochemicals that are responsible for their anticancer properties. Overall, this review provides consolidated and extensive information not only on diverse medicinal plants of Africa but on the different types of cancer that these plants are used to manage and the diverse mechanisms and pathways that are involved during cancer alleviation.

TRAIL-Sensitizing Effects of Flavonoids in Cancer

“…In fact, plant-derived medicines have been continuously researched for their pharmacological potential against various diseases (e.g., malaria, parasitic diseases, cancer) [25], and, among all Food and Drug Administration (FDA) approvals of new pharmacological entities of natural origin, 25% come from plants [26]. In the context of cancer therapy, plant-derived molecules have exhibited good anti-neoplastic activity with minimal side effects, thus representing an effective, inexpensive, and accessible therapeutic approach [27,28]. In support of this view is the fact that plant-derived anticancer agents, such as the diterpene alkaloid paclitaxel and the indole alkaloids vinblastine and vincristine, are essential drugs used in the treatment of chemotherapy for a wide range of cancer types [29].…”