Temefos’a Maruz Kalan Gökkuşağı Alabalıklarında, Antioksidan Cevaplar

Parlak, Veysel; Uçar, Arzu; Alak, Gonca; Atamanalp, Muhammed

doi:10.21597/jist.446624

Cited by 1 publication

(1 citation statement)

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“…Vol.65: e22210651, 2022 www.scielo.br/babt the pyocyanin pigment, which was shown to have antioxidant activity, can be used as a protective agent against neural injury and as an anticancer drug through its inhibitory activity on in vitro and cellular AChE enzyme activity. Studies in the literature have established the association between AChE-i activity and antioxidant activity [78][79][80][81]. Mounting evidence suggesting that neuroprotection and anticancer activity can be achieved by inhibiting AChE enzyme activity has transformed AChE enzyme activity into a guide for researchers who aim to develop novel effective agents against neurodegenerative diseases and cancer [82].…”

Section: Discussionmentioning

confidence: 99%

Pyocyanin Isolated from Pseudomonas aeruginosa: Characterization, Biological Activity and Its Role in Cancer and Neurodegenerative Diseases

Koyun

Şirin

Erdem

et al. 2022

Braz. arch. biol. technol.

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This study aimed to find a pigment of bacterial origin with protective/preventive activity against neurological injury and carcinogenesis, which may be used as a natural food additive in food activity or an active drug ingredient of an anti-neural injury/anticancer agent in the pharmaceutical industry. Within this scope, the Pseudomonas aeruginosa MB713 strain was used to produce pyocyanin. Characterization of the pyocyanin was carried out using UV-VIS, FT-IR, and GC-MS analyses. In addition, its inhibitory action on AChE and antioxidant activities were determined. The cytotoxic activities of the pyocyanin as well as its antiproliferative activities were detected. It was determined that the maximum production of the pyocyanin (51 μg/mL). The pyocyanin did not cause a cell death rate above 50% in L929 cells. The pyocyanin was found to exert an inhibitory effect on the AChE. The pyocyanin was found effective on all antioxidant parameters tested. The IC50 values of the pyocyanin on SK-MEL-30 and HT-29 cells were calculated as 72 and 179 μM, respectively. And due to the pyocyanin's antioxidant and inhibitory effects on AChE, antiproliferative effects, and protective effects against neurodegenerative injury, the use of the pyocyanin as HIGHLIGHTS• The maximum production of the pyocyanin was found to occur in MFDM and with shaking.• UV-VIS spectroscopy, GC-MS, and FT-IR analyses showed the presence of pyocyanin.• Pyocyanin had no cytotoxic impact on L929 cells (except 50-100 μM concentrations).• Pyocyanin had an antiproliferative impact on SK-MEL-30 cells.• Pyocyanin had in vitro and cellular AChE inhibitory and antioxidant properties.• The use of the pyocyanin as a neuroprotective agent or an anticancer agent is advised.

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Section: Discussionmentioning

confidence: 99%