Telomeres and Telomerase in Renal Health

Wills, Lauren P.; Schnellmann, Rick G.

doi:10.1681/asn.2010060662

Cited by 36 publications

(34 citation statements)

References 31 publications

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“…Such factors might be dysregulation of renin-angiotensin-system, oxidative stress, higher expression levels of tumor suppressor protein p53 and cell cycle inhibitor p16 INK4a as shown among individuals older than 60 years [19]. The unadjusted correlation between eGFR and RTL was 0.147 which was similar as in patients with heart failure (r=0.141 [29] and r=0.123 [30]).…”

Section: Association Of Rtl With Kidney Functionmentioning

confidence: 61%

“…This observation has led to the assumption that reduced TL is an indicator of biological age and a M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 4 potential marker and/or predictor of CVD risk and progression [16,17]. Shortened TL has been shown to be associated with CVD [18,19] and both are highly prevalent in older adults.…”

Section: Introductionmentioning

confidence: 99%

“…There is some evidence that TL correlates inversely with renal function in patients with CVD [18,19,20]. In patients with renal failure TL was found to be reduced [21] and inversely associated with mortality [22] as well as with progression of CKD [23].…”

Section: Introductionmentioning

confidence: 99%

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Association of relative telomere length with cardiovascular disease in a large chronic kidney disease cohort: The GCKD study

et al. 2015

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Section: Association Of Rtl With Kidney Functionmentioning

confidence: 61%

Section: Introductionmentioning

confidence: 99%

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Association of relative telomere length with cardiovascular disease in a large chronic kidney disease cohort: The GCKD study

et al. 2015

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“…Patients with CKD have a markedly increased risk for cardiovascular disease (CVD) (13) and total telomere shortening is associated with progression of CVD (14). We thus examined whether telomeric G-tail length could be a sensitive marker for CVD in hemodialysis patients.…”

Section: Introductionmentioning

confidence: 99%

Telomeric G-Tail Length and Hospitalization for Cardiovascular Events in Hemodialysis Patients

Hirashio

Nakashima

Doi

et al. 2014

Clinical Journal of the American Society of Nephrology

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Background and objectives Telomeric G-tails play a pivotal role in maintaining the intramolecular loop structure of telomeres. Previous in vitro studies have suggested that the erosion of telomeric G-tails triggers cellular senescence, leading to organ dysfunction and atherosclerosis. The authors recently established a method to measure telomeric G-tail length using a hybridization protection assay. Using this method, this study investigated whether telomeric G-tail length could be used as a novel predictor for future cardiovascular events in hemodialysis patients.Design, setting, participants, & measurements A prospective observational study was performed involving a cohort of 203 Japanese hemodialysis patients to examine the lengths of telomeric G-tails and total telomeres and subsequent cardiovascular events during a median follow-up period of 48 months. The lengths of telomeric G-tails and total telomeres were also measured in 203 participants who did not have CKD and who were age-and sex-matched to hemodialysis patients. ResultsThe lengths of telomeric G-tails and total telomeres were significantly shorter in hemodialysis patients than in control subjects. Telomeric G-tails, but not total telomeres, were independently and negatively associated with clinical history of cardiovascular disease. During follow-up, 80 cardiovascular events occurred. Total telomere length did not predict cardiovascular events. However, the length of telomeric G-tails was associated with new-onset cardiovascular events (hazard ratio per log luminescence signals, 0.12; 95% confidence interval, 0.12 to 0.50) that persisted after adjustment for age, sex, diabetes mellitus, clinical history of cardiovascular disease, inflammation, use of vitamin D, and serum levels of phosphate and intact parathyroid hormone.Conclusions Longer telomeric G-tail length is associated with a lower risk of future cardiovascular events in hemodialysis patients.

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“…8 Cellular changes (eg, decline in the length of telomere and antiaging factor [Klotho]), as well as inherited predisposing factors (small number of glomeruli and glutathione S-transferase mu 1 genotype) can all be in play in aging-related kidney dysfunction. [9][10][11][12] Kidney biopsy is an important part of clinical care for patients with glomerular diseases. Over the last few decades, the rate of kidney biopsy in elderly patients has increased substantially.…”

Section: Introductionmentioning

confidence: 99%