Association of relative telomere length with cardiovascular disease in a large chronic kidney disease cohort: The GCKD study

Raschenberger, Julia; Kollerits, Barbara; Titze, Stephanie; Köttgen, Anna; Bärthlein, Barbara; Ekici, Arif B.; Forer, Lukas; Schönherr, Sebastian; Weißensteiner, Hansi; Haun, Margot; Wanner, Christoph; Eckardt, Kai‐Uwe; Kronenberg, Florian

doi:10.1016/j.atherosclerosis.2015.08.020

Cited by 29 publications

(24 citation statements)

References 39 publications

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“…Moreover, the liner regression analysis identified a significant correlation between RTL and age ( r 2 = 0.028, P = 4.35 × 10 −4 , Supplementary Figure S1). These results are consistent with the previous studies .…”

Section: Resultssupporting

confidence: 94%

Genetic variants affecting telomere length are associated with the prognosis of esophageal squamous cell carcinoma in a Chinese population

Lü

Yan

et al. 2016

Molecular Carcinogenesis

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Telomeres are essential for maintaining chromosomal stability and are crucial in tumor progression. Previous studies have explored the associations between telomere length and cancer prognosis, but the findings are inconclusive. Genome-wide association studies have identified several genetic variants associated with telomere length in Caucasians. However, the roles of telomere length and related genetic variants on esophageal squamous cell carcinoma (ESCC) prognosis are largely unknown. Therefore, we conducted a case-cohort study with 431 ESCC patients to assess the associations between relative telomere length (RTL), eight known telomere length related variants and the overall survival of ESCC in Chinese population. We found that as compared with the reference group, patients in the fifth (the longest) quintile had a significantly better prognosis [(adjusted hazard ratio (HR) = 0.58, 95% confidence interval (CI) = 0.34-0.98, P = 0.041]. Furthermore, A allele of rs2736108 was significantly associated with both the increased RTL (P = 0.048) and the better prognosis of ESCC (adjusted HR = 0.55, 95%CI = 0.38-0.79, P = 1.31 × 10 ). Mediation analysis indicated that the effect of rs2736108 on ESCC prognosis was partly explained by RTL (1.99%). Stepwise Cox proportional hazard analysis suggested that rs2736108 played an important protective role in ESCC prognosis (HR = 0.57, 95%CI = 0.40-0.81, P = 1.97 × 10 ). Our findings provide evidence that prolonged telomere length is a protective factor for ESCC patients' survival and the known telomere length related genetic variant rs2736108 can contribute to the prognosis of ESCC as well in Chinese population. © 2016 Wiley Periodicals, Inc.

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Section: Resultssupporting

confidence: 94%

Genetic variants affecting telomere length are associated with the prognosis of esophageal squamous cell carcinoma in a Chinese population

Lü

Yan

et al. 2016

Molecular Carcinogenesis

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“…With advancing age (and multiple replication cycles), telomeres tend to shorten. Extensive shortening of telomeres may lead to cellular damage or senescence and increased risk of disease [14]. Telomere length (TL) has thus been suggested as a marker of cellular aging [15] with shorter TL being associated with unfavorable age-related diseases such as an increased rates of CVD and cancer [16–19].…”

Section: Introductionmentioning

confidence: 99%

Psychological Profiles in the Prediction of Leukocyte Telomere Length in Healthy Individuals

et al. 2016

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BackgroundShorter telomere length (TL) may signal premature cellular aging and increased risk for disease. While depression and psychosocial stress have been associated with shorter telomeres, other psychological risk factors for cardiovascular disease have received less attention.PurposeTo evaluate the association between TL and psychological risk factors (symptoms of anxiety and depression, hostility and defensiveness traits) for heart disease, and to examine whether chronological age and sex moderate the associations observed.Methods132 healthy men and women (Mage = 45.34 years) completed the Marlowe-Crowne Social Desirability Scale, the Beck Depression Inventory II, The Beck Anxiety Inventory and the Cook-Medley Hostility Scale. Relative TL was measured by quantitative polymerase chain reaction (PCR) of total genomic DNA samples. A series of hierarchical linear regressions were performed controlling for pertinent covariates.ResultsShorter TL was observed among individuals high in defensiveness (β = -.221) and depressive symptoms (β = -.213), as well as in those with less hostility (β =.256) and anxiety (β =.220)(all Ps<.05). Psychological variables explained 19% of the variance over and above that explained by covariates (age, sex, exercise, alcohol consumption, systemic inflammation, and 24-hr mean arterial pressure). Age moderated the relation between TL and defensiveness (β =.179, p =.03). Sex did not influence any of the relations.ConclusionsTelomere length is associated with psychological burden though the direction of effect differs depending on the psychological variables under study. Further research is needed to determine the reasons for and implications of these seemingly contradictory findings.

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“…There are many studies on telomere length and CVD risk. Most previous studies have indicated that LTL is negatively associated with CVD risk worldwide 10,24,25 . For instance, the results of a Danish study with a large sample size suggest that short telomere length is associated with only a modestly increased risk of myocardial infarction and ischaemic heart disease 26,27 .…”

Section: Discussionmentioning

confidence: 99%

Association between leucocyte telomere length and cardiovascular disease in a large general population in the United States

Wang

et al. 2020

Sci Rep

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Leucocyte telomere length (LTL) has been reported to be linked to ageing, cancer and cardiovascular disease (cVD). this study aimed to explore the association between LtL and cVD risk in a nationally representative sample of U.S. adults. Complex associations, including nonlinearity and interaction, were also examined. A total of 7,378 subjects from the National Health and Nutrition Examination Survey (NHANES) 1999-2002 were collected. Telomere length was detected from DNA samples and expressed as the mean t/S ratio (telomere repeats per single-copy gene). We performed multiple logistic regression models and interactive analysis to explore the associations between LtL and cVD risk by adjusting for potential confounders. We also performed a sensitivity analysis to investigate the robustness of our results. Among all participants, LTL was associated with the risk of CVD (OR = 0.79, 95% CI: 0.63~0.98, P = 0.033) in a linear manner rather than in a nonlinear manner (P = 0.874). Interaction effects of LTL with both education (P = 0.017) and hypertension (P = 0.007) were observed. Furthermore, using subgroup analyses, protective effects of LTL on CVD risk were found in females and in individuals who were college graduates or above, had serum cotinine >10 ng/ml, did not have hypertension, or had normal white blood cell levels. LTL is linearly inversely associated with CVD risk in the general population of the United States. Telomeres are repetitive sequences of nucleotides at the ends of chromosomes that play a role in the maintenance of genic integrity. Telomeres are involved in many physiological processes 1 such as cell senescence 2 and endometrial regeneration 3. Leucocyte telomere length (LTL) is the longest at birth and decreases with age 4. Moreover, the shortening of LTL affects the progression of diseases, including ageing 5,6 , immune dysfunction 7 , post-traumatic stress disorder 8 , diabetes 9 , cardiovascular disease (CVD) 10 , and cancer 5,11. CVD refers to heart and blood vessel abnormalities and is one of the most common causes of noncommunicable disease mortality 12 , accounting for approximately 17.5 million deaths worldwide 13. The United States has the largest number of CVD patients in the world 14. Reportedly, approximately 1,500,000 U.S. adults are affected by CVD each year 15 , and millions of Americans have CVD risk factors 16. Peng et al. found that longer LTL was associated with cardiovascular health (CVH) indices (i.e., a surrogate measure of CVD risk) in American Indians 17. Similarly, Gebreab et al. explored the associations between LTL and CVH and observed similar results in the general U.S. population, especially in females and non-Hispanic whites 18. Another report showed an inverse association between LTL and coronary artery calcification in African Americans 19. A meta-analysis reported an inverse association between LTL and the risk of CVD 10. However, among the general U.S. population, the association between LTL and the risk of CVD remains unclear. In addition, people of different eth...

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Association of relative telomere length with cardiovascular disease in a large chronic kidney disease cohort: The GCKD study

Cited by 29 publications

References 39 publications

Genetic variants affecting telomere length are associated with the prognosis of esophageal squamous cell carcinoma in a Chinese population

Genetic variants affecting telomere length are associated with the prognosis of esophageal squamous cell carcinoma in a Chinese population

Psychological Profiles in the Prediction of Leukocyte Telomere Length in Healthy Individuals

Association between leucocyte telomere length and cardiovascular disease in a large general population in the United States

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