Telomere shortening in sleep apnea syndrome

Barceló, Antònia; Piérola, Javier; López-Escribano, Herminio; Peña, Mónica de la; Soriano, Joan B.; Alonso-Fernández, Alberto; Ladaria, A; Agustí, Àlvar

doi:10.1016/j.rmed.2010.03.025

Cited by 64 publications

(49 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, contrary to the findings of our study, the severity of OSAS did not show a relationship with LTL [22]. Savolainen et al (2014) in a cross-sectional study investigated whether a history of OSAS or primary snoring had an association with LTL in later adulthood.…”

Section: Discussioncontrasting

confidence: 99%

The effect of the severity of obstructive sleep apnea syndrome on telomere length

et al. 2016

View full text Add to dashboard Cite

Aging is associated with an increase in the prevalence of obstructive sleep apnea syndrome (OSAS) as well as the shortening of telomeres. It is known that OSAS-related factors are stimuli that can contribute to the acceleration of cellular senescence. Thus, the present study aimed to compare the leukocyte telomere length (LTL) between OSAS patients and controls, as well as to verify the correlation between LTL and sleep parameters. We used DNA extracted of 928 individuals from EPISONO to measure the LTL by the quantitative real-time polymerase chain reaction. All individuals were subjected to one full-night polysomnography. LTL was significantly shorter in OSAS patients compared to controls. The results showed negative correlations between LTL and the following variables: apnea-hypopnea index, respiratory disturbance index, desaturation index and wake after sleep onset. LTL was positively correlated with sleep efficiency, total sleep time, basal, minimum and maximum oxygen saturation. Lastly, it was observed that OSAS severity was associated with shorter LTL even after adjusting for sex, age, years of schooling, body mass index, diabetes, stroke and heart attack. In conclusion, our study indicates the presence of an association between LTL and OSAS and a significant impact of severity of OSAS in telomeres shortening.

show abstract

Section: Discussioncontrasting

confidence: 99%

The effect of the severity of obstructive sleep apnea syndrome on telomere length

et al. 2016

View full text Add to dashboard Cite

show abstract

“…A point mutation in the β2-adrenoceptor gene could alter the structure and function of the receptor, thereby leading to a low density of receptors on both keratinocytes and peripheral blood lymphocytes [136]. Receptor mutation or polymorphism is also associated with AD [13, 136]. So the catecholamines signaling is probably still dysfunctional even with upregulated ligand.…”

Section: Skin Neurogenic Inflammation During Stress Responsesmentioning

confidence: 99%

Brain-Skin Connection: Stress, Inflammation and Skin Aging

Chen

Lyga²

2014

IADT

175

161

View full text Add to dashboard Cite

The intricate relationship between stress and skin conditions has been documented since ancient times. Recent clinical observations also link psychological stress to the onset or aggravation of multiple skin diseases. However, the exact underlying mechanisms have only been studied and partially revealed in the past 20 years or so. In this review, the authors will discuss the recent discoveries in the field of “Brain-Skin Connection”, summarizing findings from the overlapping fields of psychology, endocrinology, skin neurobiology, skin inflammation, immunology, and pharmacology.

show abstract

“…Finally, we did not assess for the presence of clinical sleep disorders, such as obstructive sleep apnea (OSA), in this study. This is an important issue given that adults with OSA have been shown to exhibit shorter LTL compared to those without OSA [39]. Notably, the presence of OSA in children is associated with longer LTL [40].…”

Section: Discussionmentioning

confidence: 99%

Assessing the scholarly impact of health psychology: A citation analysis of articles published from 1993 to 2003.

Frosch¹,

Saxbe²,

Tomiyama³

et al. 2010

Health Psychology

View full text Add to dashboard Cite

Background. Accumulating evidence supports leukocyte telomere length (LTL) as a biological marker of cellular aging. Poor sleep is a risk factor for age-related disease; however, the extent to which sleep accounts for variation in LTL is unknown. Methods. The present study examined associations of self-reported sleep duration, onset latency, and subjective quality with LTL in a communitydwelling sample of 245 healthy women in midlife (aged 49-66 years). Results. While sleep duration and onset latency were unrelated to LTL, women reporting poorer sleep quality displayed shorter LTL (r = 0.14, P = 0.03), independent of age, BMI, race, and income (b = 55.48, SE = 27.43, P = 0.04). When analyses were restricted to participants for whom sleep patterns were chronic, poorer sleep quality predicted shorter LTL independent of covariates and perceived psychological stress. Conclusions. This study provides the first evidence that poor sleep quality explains significant variation in LTL, a marker of cellular aging.

show abstract

Telomere shortening in sleep apnea syndrome

Cited by 64 publications

References 17 publications

The effect of the severity of obstructive sleep apnea syndrome on telomere length

The effect of the severity of obstructive sleep apnea syndrome on telomere length

Brain-Skin Connection: Stress, Inflammation and Skin Aging

Assessing the scholarly impact of health psychology: A citation analysis of articles published from 1993 to 2003.

Contact Info

Product

Resources

About