Telomere length, vitamin B12 and mortality in persons undergoing coronary angiography: the Ludwigshafen risk and cardiovascular health study

Pusceddu, Irene; Herrmann, Wolfgang; Kleber, Marcus E.; Scharnagl, Hubert; März, Winfried; Herrmann, Markus

doi:10.18632/aging.102238

Cited by 20 publications

(18 citation statements)

References 51 publications

(98 reference statements)

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“…A review by Rafnsson concluded that there was limited evidence that vitamin B12 deficiency predisposes to the risk of mortality and morbidity from either cardiovascular diseases or diabetes in adults [32]. Data from the LURIC study, however, showed a similar U-shaped curve for the association between serum B12 and mortality as in the present study [33]. These authors proposed that in low serum B12, mortality-and the accompanying accelerated telomere shortening-might be driven by increased concentrations of homocysteine, while in participants with high serum B12, this might be related to increased inflammation.…”

Section: Discussioncontrasting

confidence: 54%

“…We clearly showed that the use of vitamin B12-containing supplements has increased during the more recent NHANES surveys and was significantly higher in participants with hypertension, dyslipidemia, CVD, and an earlier diagnosis of cancer. The association between elevated serum B12 and cardiovascular mortality, together with the absence of any association between high B12 supplement intake and mortality likely indicates “reverse causality.” The increased use of vitamin B12-containing supplements by people with a chronic (cardiovascular) condition supports this conclusion, as well as the growing body of literature that serum B12 concentrations increase in states of inflammation [ 33 ]. However, there are several other factors which by themselves may negatively influence long-term morbidity and mortality, and are associated with higher serum B12 concentrations, for instance, high consumption of red meat.…”

Section: Discussionmentioning

confidence: 79%

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Relationship between serum B12 concentrations and mortality: experience in NHANES

Wolffenbuttel

Heiner‐Fokkema

Green

et al. 2020

BMC Med

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Background There is conflicting evidence in the literature on the association between (elevated) serum B12 concentrations and subsequent disease or mortality. We evaluated in the NHANES general population the association of serum B12 concentrations as well as vitamin B12 supplement intake with all-cause, cardiovascular, and cancer-related mortality, while taking into account demographic and lifestyle factors and significant other diseases which are known to be associated with poorer outcome. Methods The main outcomes of our study were all-cause mortality, cardiovascular mortality, and cancer-related mortality. Mortality status and cause of death were determined by NHANES-linked National Death Index public access files through December 31, 2015. The association of serum B12 concentrations and vitamin B12 supplement intake with mortality was assessed with Cox proportional hazard (PH) models, with adjustment for a number of relevant demographic and lifestyle factors and comorbidity. Results The final study population of 24,262 participants had a mean age of 48 (SD 19) years; 50.1% were males. The median follow-up duration was 109 months (range 1–201 months). On the census day of December 31, 2015, 3023 participants were determined as deceased (12.5%). The fully adjusted Cox PH model indicated that low serum B12 concentrations < 140 pmol/l were associated with a small increase in all-cause (hazard ratio, HR 1.39, 95% CI 1.08–1.78, p = 0.011) and cardiovascular (HR 1.64, 95% CI 1.08–2.47, p = 0.020) mortality. Similarly, high serum B12 concentrations > 700 pmol/l were associated with an increase in cardiovascular mortality only (HR 1.45, 95% CI 1.01–2.06, p = 0.042). Participants with a diagnosis of hypertension, dyslipidemia, CVD, and cancer more frequently used vitamin B12-containing supplements than those without these diagnoses. We could not demonstrate an association between vitamin B12 supplement intake and mortality, when adjusted for comorbidity. Conclusions In the general population of NHANES, low serum B12 concentrations were associated with a moderate increase in all-cause mortality. There was a small but significant increase in cardiovascular mortality in the groups with low or high serum B12. High intake of vitamin B12 in the form of supplements was not associated with any adverse effect on mortality and therefore can be regarded as safe.

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Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 79%

Relationship between serum B12 concentrations and mortality: experience in NHANES

Wolffenbuttel

Heiner‐Fokkema

Green

et al. 2020

BMC Med

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“…Until now, the relationship between LTL and B12 has not been studied comprehensively, and the few existing data are inconsistent [ 63 , 96 , 97 ]. In the LURIC study [ 108 ], B12 was associated with all-cause-mortality, LTL and high sensitive C-reactive protein (hsCRP) in a non-linear fashion [ 108 ].…”

Section: B-vitamins Homocysteine Telomere Length and Cvdmentioning

confidence: 99%

The Importance of Telomere Shortening for Atherosclerosis and Mortality

Herrmann

2020

JCDD

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Telomeres are the protective end caps of chromosomes and shorten with every cell division. Short telomeres are associated with older age and adverse lifestyle factors. Leucocyte telomere length (LTL) has been proposed as a biomarker of biological age. The shortening of LTL with age is the result of the end-replication problem, environmental, and lifestyle-related factors. Epidemiologic studies have shown that LTL predicts cardiovascular disease, all-cause mortality, and death from vascular causes. Age appears to be an important co-variate that explains a substantial fraction of this effect. Although it has been proposed that short telomeres promote atherosclerosis and impair the repair of vascular lesions, existing results are inconsistent. Oxidative stress and chronic inflammation can both accelerate telomere shortening. Multiple factors, including homocysteine (HCY), vitamin B6, and vitamin B12 modulate oxidative stress and inflammation through direct and indirect mechanisms. This review provides a compact overview of telomere physiology and the utility of LTL measurements in atherosclerosis and cardiovascular disease. In addition, it summarizes existing knowledge regarding the impact of oxidative stress, inflammation, HCY, and B-vitamins on telomere function.

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“…Also, nutritional factors can modulate telomere length [41][42][43]. In particular, a sufficient supply with micronutrients like vitamin A, D, C, E, B12, folate, and nicotinamide is positively associated with telomere length [44][45][46][47][48]. Minerals like magnesium, zinc, and iron, and other dietary components, such as omega-3 fatty acid, polyphenols, and curcumin, are additional modulators of telomere length.…”

Section: Influencing Factors Of Telomere Lengthmentioning

confidence: 99%

Telomeres and Age-Related Diseases

et al. 2021

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Telomeres are at the non-coding ends of linear chromosomes. Through a complex 3-dimensional structure, they protect the coding DNA and ensure appropriate separation of chromosomes. Aging is characterized by a progressive shortening of telomeres, which compromises their structure and function. Because of their protective function for genomic DNA, telomeres appear to play an important role in the development and progression of many age-related diseases, such as cardiovascular disease (CVD), malignancies, dementia, and osteoporosis. Despite substantial evidence that links telomere length with these conditions, the nature of these observations remains insufficiently understood. Therefore, future studies should address the question of causality. Furthermore, analytical methods should be further improved with the aim to provide informative and comparable results. This review summarize the actual knowledge of telomere biology and the possible implications of telomere dysfunction for the development and progression of age-related diseases. Furthermore, we provide an overview of analytical techniques for the measurement of telomere length and telomerase activity.

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Telomere length, vitamin B12 and mortality in persons undergoing coronary angiography: the Ludwigshafen risk and cardiovascular health study

Cited by 20 publications

References 51 publications

Relationship between serum B12 concentrations and mortality: experience in NHANES

Relationship between serum B12 concentrations and mortality: experience in NHANES

The Importance of Telomere Shortening for Atherosclerosis and Mortality

Telomeres and Age-Related Diseases

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