Telomere length may be associated with hypertension

Fw, Lung; Cs, Ku; Wt, Kao

doi:10.1038/sj.jhh.1002314

Cited by 39 publications

(41 citation statements)

References 12 publications

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“…Giving the strong genetic determination of telomere length [46], the risk factor adjusted association between PTSD and TL is a remarkable finding – although in line with earlier investigations which have shown associations of TL with long acting psychological stress conditions and sustained negative affectivity (major depression, anxiety) [10], [19]–[21], [25]–[29], [34].…”

Section: Discussionsupporting

confidence: 77%

“…Depression has been associated with shorter telomeres in clinical populations with severe and long acting disease conditions [10], [25]–[27]. In particular, depression was also associated with shorter telomeres in patients with coronary heart disease even after adjustment for somatic risk factors [28].…”

Section: Introductionmentioning

confidence: 98%

“…Previous studies showed substantial associations of TL with sex and age [4] as well as with obesity [5], [6], current smoking [7], alcohol consumption [8], physical inactivity [9], hypertension [10], cholesterol [11] and a variety of chronic disease conditions such as metabolic diseases or cancer [12]–[14]. Additionally, sustained states of severe mental stress and adverse affective conditions have also been associated with shorter TL.…”

Section: Introductionmentioning

confidence: 99%

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Posttraumatic Stress Disorder and Not Depression Is Associated with Shorter Leukocyte Telomere Length: Findings from 3,000 Participants in the Population-Based KORA F4 Study

et al. 2013

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BackgroundA link between severe mental stress and shorter telomere length (TL) has been suggested. We analysed the impact of Posttraumatic Stress Disorder (PTSD) on TL in the general population and postulated a dose-dependent TL association in subjects suffering from partial PTSD compared to full PTSD.MethodsData are derived from the population-based KORA F4 study (2006–2008), located in southern Germany including 3,000 individuals (1,449 men and 1,551 women) with valid and complete TL data. Leukocyte TL was measured using a quantitative PCR-based technique. PTSD was assessed in a structured interview and by applying the Posttraumatic Diagnostic Scale (PDS) and the Impact of Event Scale (IES). A total of 262 (8.7%) subjects qualified for having partial PTSD and 51 (1.7%) for full PTSD. To assess the association of PTSD with the average TL, linear regression analyses with adjustments for potential confounding factors were performed.ResultsThe multiple model revealed a significant association between partial PTSD and TL (beta = −0.051, p = 0.009) as well as between full PTSD and shorter TL (beta = −0.103, p = 0.014) indicating shorter TL on average for partial and full PTSD. An additional adjustment for depression and depressed mood/exhaustion gave comparable beta estimations.ConclusionsParticipants with partial and full PTSD had significantly shorter leukocyte TL than participants without PTSD. The dose-dependent variation in TL of subjects with partial and full PTSD exceeded the chronological age effect, and was equivalent to an estimated 5 years in partial and 10 years in full PTSD of premature aging.

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Section: Discussionsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Posttraumatic Stress Disorder and Not Depression Is Associated with Shorter Leukocyte Telomere Length: Findings from 3,000 Participants in the Population-Based KORA F4 Study

et al. 2013

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“…China and south of Chinese Taipei [25,26]. Therefore, the biological markers of aging can be better understood by also considering changes to telomere length as important for the pathophysiology of hypertension.…”

Section: Commonalities Between Hypertension and Agingmentioning

confidence: 99%

Telomeres and essential hypertension

Wang

2015

Clinical Biochemistry

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“…Telomere length declines gradually with age and has been used as a valuable biomarker for cellular senescence and biological aging. Shorter leukocyte telomere length (LTL) has been associated with a variety of age-related disorders, such as hypertension [2], diabetes [3], cardiovascular diseases (CVD) [4, 5] and certain types of cancers [6, 7]. …”

Section: Introductionmentioning

confidence: 99%

Short leukocyte telomere length is associated with obesity in American Indians: The strong heart family study

Chen

Yeh

Lin

et al. 2014

Aging

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Shorter leukocyte telomere length (LTL) has been associated with a wide range of age-related disorders including cardiovascular disease (CVD) and diabetes. Obesity is an important risk factor for CVD and diabetes. The association of LTL with obesity is not well understood. This study for the first time examines the association of LTL with obesity indices including body mass index, waist circumference, percent body fat, waist-to-hip ratio, and waist-to-height ratio in 3,256 American Indians (14-93 years old, 60% women) participating in the Strong Heart Family Study. Association of LTL with each adiposity index was examined using multivariate generalized linear mixed model, adjusting for chronological age, sex, study center, education, lifestyle (smoking, alcohol consumption, and total energy intake), high-sensitivity C-reactive protein, hypertension and diabetes. Results show that obese participants had significantly shorter LTL than non-obese individuals (age-adjusted P=0.0002). Multivariate analyses demonstrate that LTL was significantly and inversely associated with all of the studied obesity parameters. Our results may shed light on the potential role of biological aging in pathogenesis of obesity and its comorbidities.

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Telomere length may be associated with hypertension

Cited by 39 publications

References 12 publications

Posttraumatic Stress Disorder and Not Depression Is Associated with Shorter Leukocyte Telomere Length: Findings from 3,000 Participants in the Population-Based KORA F4 Study

Posttraumatic Stress Disorder and Not Depression Is Associated with Shorter Leukocyte Telomere Length: Findings from 3,000 Participants in the Population-Based KORA F4 Study

Telomeres and essential hypertension

Short leukocyte telomere length is associated with obesity in American Indians: The strong heart family study

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