Telomere Length in Elderly Caucasians Weakly Correlates with Blood Cell Counts

Gutmajster, Ewa; Witecka, Joanna; Wyskida, Magdalena; Koscinska-Marczewska, J.; Szwed, Małgorzata; Owczarz, Magdalena; Mossakowska, Małgorzata; Milewicz, Andrzej; Puzianowska-Kuźnicka, Monika; Zejda, Jan; Wiȩcek, Andrzej; Chudek, Jerzy; Sieroń, Aleksander

doi:10.1155/2013/153608

Cited by 14 publications

(14 citation statements)

References 26 publications

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“…Den Elzen et al proposed an explanation for the lack of association between telomere length and hematological parameters in elderly people – that telomere length in WBC in old age is unstable and does not have enough predictive power for age-related morbidity and mortality at ages over 85 years [26, 28]. However, Gutmajster et al found a weak and independent correlation of TL with both RBC and WBC in elderly individuals [29]. Therefore, the type of cells studied (peripheral blood mononuclear cells, hematopoietic cells, lymphocytes, etc.)…”

Section: Discussionmentioning

confidence: 99%

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Association between telomere length and complete blood count in US adults

Mazidi¹,

Penson²,

Banach³

2017

aoms

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IntroductionTelomere length (TL) is related to age-related health outcomes, but little is known about the relationship between TL and complete blood count (CBC) parameters. We aimed to determine the relationship between TL and CBC in a sample of healthy US adults.Material and methodsParticipants in the National Health and Nutrition Examination Survey (NHANES) recruited between 1999 and 2002 who had essential data on total CBC and TL were studied. We computed age- and race-adjusted mean values for total CBC using analysis of covariance (ANCOVA). All statistical analyses accounted for the survey design and sample weights by using SPSS Complex Samples v22.0 (IBM Corp, Armonk, NY).ResultsOf the 8892 eligible participants, 47.8% (n = 4123) were men. The mean age was 41.8 years overall, 41.0 years in men and 42.6 in women (p = 0.238). The sex-stratified ANCOVA showed no significant difference in the total CBC across TL quartiles (all p > 0.05) in both sexes. In the adjusted model, there was a significant negative relationship with monocyte count (β = –0.051, 95% CI: –0.422; –0.142), mean cell hemoglobin (β = –0.051, 95% CI: –0.038; –0.011) and red cell distribution width (β = –0.031, 95% CI: –0.054; –0.003), while there was a significant positive relationship with basophil ratio (β = 0.046, 95% CI: 0.049–0.171).ConclusionsThese results support the possibility that telomere attrition may be a marker for reduced proliferative reserve in hematopoietic progenitor cells.

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Section: Discussionmentioning

confidence: 99%

“…Shorter TL in men may explain gender-specific dissimilarities in the degree of peripheral blood cell count. Therefore, in comparison to women, it should be easier to identify associations in men [29]. In addition, other potential confounders including stress and cortisol can affect telomere length and WBC counts [22, 30, 31].…”

Section: Discussionmentioning

confidence: 99%

Association between telomere length and complete blood count in US adults

Mazidi¹,

Penson²,

Banach³

2017

aoms

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“…In 2 cases, the results were interpreted as a negative finding showing that in the study populations analyzed, no association of the investigated blood parameters and TL was detected [15,17]. The other two groups stated that they found associations between RBC count and/or leukocytes [14,25] and TL as the major result of their study. Another study reported significant associations of the closely related parameters MCV, RDW, hemoglobin and marginally also RBC count [16], although the observed effect sizes were rather weak.…”

Section: Discussionmentioning

confidence: 99%

Relative Leukocyte Telomere Length, Hematological Parameters and Anemia - Data from the Berlin Aging Study II (BASE-II)

Meyer

Salewsky²,

Buchmann

et al. 2016

Gerontology

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Background: The length of the chromosome ends, telomeres, is widely accepted as a biomarker of aging. However, the dynamic of the relationship between telomere length and hematopoietic parameters in the normal aging process, which is of particular interest with respect to age-related anemia, is not well understood. Objective: We have analyzed the relationship between relative leukocyte telomere length (rLTL) and several hematological parameters in the older group of the Berlin Aging Study II (BASE-II) participants. This paper also compares rLTL between both BASE-II age groups (22-37 and 60-83 years). Methods: Genomic DNA was extracted from peripheral blood leukocytes of BASE-II participants and used to determine rLTL by a quantitative PCR protocol. Standard methods were used to determine blood parameters, and the WHO criteria were used to identify anemic participants. Results: Telomere length data were available for 444 younger participants (28.4 ± 3.1 years old; 52% women) and 1,460 older participants (68.2 ± 3.7 years old; 49.4% women). rLTL was significantly shorter in BASE-II participants of the older group (p = 3.7 × 10^-12) and in women (p = 4.2 × 10^-31). rLTL of older men exhibited a statistically significant, positive partial correlation with mean corpuscular hemoglobin (MCH; p = 0.012) and MCH concentration (p = 0.002). While these correlations were only observed in men, the rLTL of older women was negatively correlated with the number of thrombocytes (p = 0.015) in the same type of analysis. Among all older participants, 6% met the criteria to be categorized as ‘anemic'; however, there was no association between anemia and rLTL. Conclusion: In the present study, we have detected isolated correlations between rLTL and hematological parameters; however, in all cases, rLTL explained only a small part of the variation of the analyzed parameters. In disagreement with some other studies showing similar data, we interpret the association between rLTL and some of the hematological parameters studied here to be at most marginal. This applies also to the role of rLTL in anemia, at least in the age group investigated here. Since BASE-II is yet another large cohort in which women have on average shorter telomeres than men, this finding will be addressed in the discussion with respect to the ongoing debate on gender differences in telomere length.

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“…Conflicting results have similarly been described for leukocytes. Gutmajster and colleagues have seen an association of white blood cell count and TL in elderly Caucasians [ 34 ] and Aulinas et al have seen such a correlation in patients with hypercortisolism [ 35 ]. By contrast, Satoh and co-workers were unable to show an association between TL and leukocyte count [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Telomere Length Is Not Related to Established Cardiovascular Risk Factors but Does Correlate with Red and White Blood Cell Counts in a German Blood Donor Population

et al. 2015

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Telomere length (TL) is considered a marker of biological aging and has been associated with the presence of various coronary risk factors in patients. Much less is known about the relationships between TL and classic coronary risk factors in other populations. We measured TL in peripheral blood leukocytes of 343 middle-aged blood donors (mean age 40.2 ± 12.4 years; 201 men, 142 women) using quantitative polymerase chain reaction. Median TL was 0.86 (range: 0.48–1.85) relative TL units. In linear regression analyses with natural log-transformed T to S ratio as the dependent variable, there was a significant association with age (per year: beta = -0.007, p<0.001) and sex (males vs. females: beta = 0.075, p = 0.007) with longer telomeres in men. After adjusting for these two variables, we observed no association of TL with classic coronary risk factors including cholesterol (p = 0.36), triglyceride (p = 0.09), HDL-cholesterol (p = 0.26), LDL-cholesterol (p = 0.36), smoking (p = 0.97), and personal (p = 0.46) or family history (p = 0.63) of cardiovascular disease. However, we did find a significant positive association with white (p = 0.011) and red blood cell count (p = 0.031), hemoglobin (p = 0.014) and hematocrit (p = 0.013); we also found a borderline positive association with thrombocytes (p = 0.074). Positive associations remained significant for hemoglobin (p = 0.017), hematocrit (p = 0.023), and leukocytes (p = 0.009) in a subgroup with no reported vascular disease; associations were of borderline significance for erythrocytes (p = 0.053) and thrombocytes (p = 0.088) in this subgroup. The data do not support the concept that classic coronary risk factors contribute to telomere attrition in a blood donor population. However, telomere attrition may be a marker for reduced proliferation reserve in hematopoietic progenitor cells.

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Telomere Length in Elderly Caucasians Weakly Correlates with Blood Cell Counts

Cited by 14 publications

References 26 publications

Association between telomere length and complete blood count in US adults

Association between telomere length and complete blood count in US adults

Relative Leukocyte Telomere Length, Hematological Parameters and Anemia - Data from the Berlin Aging Study II (BASE-II)

Telomere Length Is Not Related to Established Cardiovascular Risk Factors but Does Correlate with Red and White Blood Cell Counts in a German Blood Donor Population

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